Abstract: This disclosure provides design, material, manufacturing method, and use alternatives for medical devices. An example aspiration catheter includes a catheter shaft having a proximal end region, a distal end region and a lumen extending therein. The aspiration catheter also includes a tip member having a length and a lumen extending therein, wherein the tip member is coupled to the distal end region of the catheter shaft and a guidewire shaft having a proximal end region and a distal end region. Further, the guidewire shaft extends within at least a portion of the lumen of the catheter shaft and the lumen of the tip member. Further, the distal end region of the guidewire shaft includes an interlock region and a portion of the tip member is engaged with at least a portion of the interlock region.