Abstract: A device for vacuum-assisted in vivo delivery of an agent into cells of tissue includes a housing that defines a chamber and at least one opening into the chamber. A port extends through the housing, is remote from the at least one opening, and is connectable to a vacuum source. The port is configured to communicate vacuum pressure from the vacuum source to the chamber for drawing tissue through the opening and into the chamber.

Abstract: A device for vacuum-assisted in vivo electroporation of tissue includes a housing that defines a chamber and at least one opening into the chamber. A port extends through the housing, is remote from the at least one opening, and is connectable to a vacuum source. The port is configured to communicate vacuum pressure from the vacuum source to the chamber. A plurality of electrodes are positioned within the chamber and are configured to deliver one or more electroporation pulses to a targeted portion of tissue extending through the opening and held in the chamber responsive to the vacuum pressure.

Abstract: A self cleaning pet litter box for receiving animal waste including an upwardly open pan containing cat litter being mounted for rotation on a support frame, a collection container for receiving animal waste removed from the pan, a raking mechanism for gathering and removing animal waste from the rotating cat litter pan into the collection container. A supply chamber replenishes litter to the pan. The litter box includes an electronic control system including an electro-optical intrusion detector.