Abstract: A catheter system (100) for treating a treatment site (106) within or adjacent to a vessel wall (108A) or a heart valve includes a light source (124), a first light guide (122A), a second light guide (122A), and a guide bundle (152). The light source (124) generates light energy. The first light guide (122A) receives the light energy from the light source (124) and has a guide proximal end (122P). The second light guide (122A) receives the light energy from the light source (124) and has a guide proximal end (122P). A guide bundle (152) is in optical communication with the light source (124). The guide bundle (152) bundles the first light guide (122A) and the second light guide (122A). The guide bundle (152) includes a first ferrule (778) that engages the guide proximal end (122P) of the first light guide (122A) and a second ferrule (778) that engages the guide proximal end (122P) of the second light guide (122A).

Abstract: A catheter system (100) for treating a treatment site (106) includes a catheter (102), a system console (123) that includes a console connection aperture (148), an energy source (124), one or more energy guides (122A) that receive energy from the energy source (124), and an optoelectrical connector (151) that is coupled to the catheter (102). The optoelectrical connector (151) includes a guide coupling housing (250) that retains at least a portion of each of the energy guides (122A). The guide coupling housing (250) is configured to be selectively mechanically connected to the system console (123) via the console connection aperture (148) so that the energy guides (122A) are adjustably aligned relative to the energy from the energy source (124).

Abstract: A catheter system (100) for placement within a blood vessel (108) having a vessel wall (108A) for treating a treatment site (106) within or adjacent to the vessel wall (108A) within a body (107) of a patient (109) includes a system console (123), one or more energy guides (122A), and an optical connector assembly (251). The system console (123) includes an energy source (124) and a console connection aperture (148). The one or more energy guides (122A) are configured to receive energy from the energy source (124). The optical connector assembly (251) includes a guide coupling housing (250) that retains at least a portion of each of the one or more energy guides (122A).

Abstract: A catheter system for treating a treatment site within or adjacent to a vessel wall includes a light source, a balloon, a light guide, and an optical analyzer assembly. The light source generates light energy. The balloon is positionable substantially adjacent to the vascular lesion. The balloon has a balloon wall that defines a balloon interior that receives a balloon fluid. The light guide receives light energy from the light source at a guide proximal end and guides the light energy toward a guide distal end and into the balloon interior. The optical analyzer assembly is configured to optically analyze light energy emitted from the guide proximal end of the light guide.

Abstract: A catheter system configured to use a guidewire lumen, includes an energy source, a first energy guide, and a first emitter station including a first station housing. The energy source generates first energy. The first energy guide receives the first energy from the energy source. The first energy guide has a first guide distal end. The first station housing has (a) a first housing base configured to be secured at least partially about the guidewire lumen, (b) a first guide retainer that extends away from the first housing base, the first guide retainer being configured to selectively receive and retain the first guide distal end of the first energy guide, and (c) a first corresponding plasma target that is spaced apart from the first guide retainer. The first housing base, the first guide retainer, and the first corresponding plasma target are integrally formed with one another.

Abstract: A protective sleeve (229) for protecting a balloon (204) of an intravascular lithotripsy catheter system (200) only prior to the balloon (204) being positioned within a body (107) of a patient (109), includes a sleeve body (229B) that is configured to be removably positioned about the balloon (204). The sleeve body (229B) includes a sleeve proximal end (229P) and a sleeve distal end (229D). The sleeve body (229B) includes a tapered region (264C) having a tapered diameter (262V) that decreases in a direction from the sleeve proximal end (229P) toward the sleeve distal end (229D).

Abstract: A catheter system (100) for placement within a blood vessel (108) having a vessel wall (108A) for treating a treatment site (106) within or adjacent to the vessel wall (108A) within a body (107) of a patient (109) includes a system console (123), one or more energy guides (122A), and an optical connector assembly (251). The system console (123) includes an energy source (124) and a console connection aperture (148). The one or more energy guides (122A) are configured to receive energy from the energy source (124). The optical connector assembly (251) includes a guide coupling housing (250) that retains at least a portion of each of the one or more energy guides (122A).

Abstract: A catheter system (100) for treating a treatment site (106) within or adjacent to a vessel wall (108A) of a blood vessel (108), or within or adjacent to a heart valve, includes an energy source (124) and a system controller (126). The energy source (124) generates a plurality of energy pulses. The system controller (126) includes a processor that controls the energy source (124). The system controller (126) is configured to implement an energy control algorithm to control both of (i) a pulse frequency of the plurality of energy pulses, and (ii) an energy level for each of the plurality of energy pulses that are generated by the energy source (124). As the pulse frequency of the plurality of energy pulses increases, the energy level for each of the plurality of energy pulses decreases.

Abstract: A catheter system (100) for treating a treatment site (106) within or adjacent to a vessel wall (108) or heart valve includes a balloon (104) having a balloon length (204L). The balloon (104) is configured to be movable between an inflated state (135) and a deflated state. The balloon (104) includes (i) a balloon proximal region (250), (ii) a balloon distal region (254), and (iii) a balloon transition region (252). The balloon proximal region (250) has a balloon proximal end (204P) and a substantially constant balloon proximal region diameter (256) while the balloon (104) is in the inflated state (135). The balloon distal region (254) has a balloon distal end (104D), and a substantially constant balloon distal region diameter (262) while the balloon (104) is in the inflated state (135). The balloon distal region diameter (262) is different than the balloon proximal region diameter (256). The balloon transition region (252) has a balloon transition region diameter (260) that varies.

Abstract: A method for treating a vascular lesion within or adjacent to a vessel wall within a body of a patient by generating a plasma that creates pressure waves adjacent to the vascular lesion, includes the steps of (i) generating light energy in the form of a source beam with a single light source; (ii) positioning a multiplexer in a beam path of the source beam, the multiplexer including an optical element; (iii) receiving the source beam with the optical element of the multiplexer; (iv) splitting the source beam into a first guide beam and a second guide beam with the optical element of the multiplexer; (v) directing the first guide beam to a first light guide with the multiplexer; and (vi) directing the second guide beam to a second light guide with the multiplexer.

Abstract: A catheter system for treating a vascular lesion within or adjacent to a vessel wall within a body of a patient includes a single light source that generates light energy, a first light guide and a second light guide, and a multiplexer. The first light guide and the second light guide are each configured to selectively receive light energy from the light source. The multiplexer receives the light energy from the light source in the form of a source beam and selectively directs the light energy from the light source in the form of individual guide beams to each of the first light guide and the second light guide.

Abstract: A catheter system for treating a treatment site includes an energy source, a balloon, an energy guide, and a pressure sensor. The balloon is positionable substantially adjacent to the treatment site. The balloon has a balloon wall that defines a balloon interior that receives a balloon fluid. The energy source generates energy that is received by the energy guide so that the energy guide can guide the light energy into the balloon interior. The pressure sensor senses a balloon pressure of the balloon fluid.

Abstract: A method for manufacturing a catheter (102) including a rapid exchange port (157). The method can include the steps of generating a port (258) in a catheter shaft (210), inserting a guidewire lumen (118) into the port (258), pulling the guidewire lumen (118) in a proximal direction, and pushing the guidewire lumen (118) in a distal direction so that the guidewire lumen (118) is within the catheter shaft (210). The method can also include the steps of thermally bonding the guidewire lumen (118) within the catheter shaft (210), trimming the guidewire lumen (118) so that a guidewire lumen (118) proximal end is flush with a catheter shaft (210) exterior.

Abstract: A catheter system (100) usable for treating a treatment site (106) within or adjacent to a vessel wall (108A) of a blood vessel (108) or a heart valve within a body (107) of a patient (109), the catheter system (100) can include an energy source (124) that generates energy, a catheter (102) that includes an energy guide (122A) that receives the energy from the energy source (124), and a system controller (126) that is coupled to the energy source (124), the system controller (126) being configured to: (i) monitor real-time operating parameters of the catheter system (100), including at least energy delivery characteristics and treatment site conditions, (ii) detect and identify operating parameters that require adjustment, (iii) automatically adjust operating parameters, and (iv) dynamically provide a summary of system status, treatment progress, and actionable alerts.

Abstract: A catheter system (100) for treating a treatment site (106) within or adjacent to a blood vessel (109) or a heart valve within the body of a patient includes an energy source (124), a fiber assembly (568), and an emitter assembly (670). The energy source (124) generates energy. The fiber assembly (568) receives the energy from the energy source (124). The fiber assembly (568) has a proximal cross-section and a distal cross-section. The proximal cross-section has a proximal height (550H) and a proximal width (550W). The distal cross-section has a distal height (559H) and a distal width (559W). The proximal height (550H) is substantially equal to the proximal width (550W). The distal height (559H) is less than the distal width (559W).

Abstract: A catheter system (100) for treating a vascular lesion (106A) within or adjacent to a vessel wall (108A) of a blood vessel (108) within a body (107) of a patient (109) includes a catheter shaft (210); a handle assembly (228); and a source manifold (236). The handle assembly (228) is coupled to the catheter shaft (210). The handle assembly (228) includes an assembly housing (266). The handle assembly (228) is usable by a user to selectively position the catheter shaft (210) near the vascular lesion (106A). The source manifold (236) is coupled to the assembly housing (266). The source manifold (236) includes a manifold housing (282) having a catheter shaft port (264) that is configured to receive a portion of the catheter shaft (210) so that the catheter shaft (210) is coupled to the manifold housing (282).

Abstract: A catheter system (100) for treating a treatment site (106) includes an energy source (124), a balloon (104), an energy guide (122A), and a balloon integrity protection system (142). The energy source (124) generates pulses of energy. The balloon (104) is positionable substantially adjacent to the treatment site (106). The balloon (104) has a balloon wall (130) that defines a balloon interior (146). The balloon (104) is configured to retain a balloon fluid (132) within the balloon interior (146). The energy guide (122A) is configured to receive the energy from the energy source (124) and guide the energy into the balloon interior (146) so that plasma is formed in the balloon fluid (132) within the balloon interior (146). The balloon integrity protection system (142) is operatively coupled to the balloon (104).

Abstract: A catheter system (200) for treating a treatment site (106) includes an energy source (124), an energy guide (222A) and an emitter (231). The energy guide (222A) receives energy (243) from the energy source (124). The emitter (231) includes (i) a guide distal end (222D) of the energy guide (222A), (ii) a plasma target (233) spaced apart from the guide distal end (222D), the energy guide (222A) emitting the energy (243) away from the guide distal end (222D) and toward the plasma target (233) so that plasma (134) is generated at the plasma target (233), and (iii) an emitter housing (260) secured to the energy guide (222A) and one of secured to and integrally formed with the plasma target (233) to maintain a relative position between the guide distal end (222D) and the plasma target (233). The emitter housing (260) includes a housing surface (260S), with a coating (260C) being provided on the housing surface (260S).

Abstract: A catheter system (100) for treating a treatment site (106) within or adjacent to the vessel wall of a blood vessel (108), or the heart valve, includes an energy source (124), a balloon (104), an energy guide (122A), and a balloon integrity protection system (142). The energy source (124) generates energy. The balloon (104) is positionable substantially adjacent to the treatment site (106). The balloon (104) has a balloon wall (130) that defines a balloon interior (146). The balloon (104) is configured to retain a balloon fluid (132) within the balloon interior (146). The energy guide (122A) is configured to receive energy from the energy source (124) and guide the energy into the balloon interior (146) so that plasma is formed in the balloon fluid (132) within the balloon interior (146). The balloon integrity protection system (142) is operatively coupled to the balloon (104).

Abstract: A method for treating a treatment site (106) within or adjacent to a heart valve (108) within a body of a patient includes the steps of generating energy with an energy source (124); receiving energy from the energy source (124) with an energy guide (122A); positioning a balloon assembly (104) adjacent to the treatment site (106), the balloon assembly (104) including an outer balloon (104B) and an inner balloon (104A) that is positioned within and at least partially spaced-apart from the outer balloon (104B) to define an interstitial space (146A) therebetween that is configured to retain a balloon fluid (132); and positioning a portion of the energy guide (122A) that receives the energy from the energy source (124) within the interstitial space (146A) between the balloons (104A, 104B) so that a plasma-induced bubble (134) is formed in the balloon fluid (132) within the interstitial space (146A).