Abstract: The present technology is generally directed to adjustable shunting systems, including adjustable shunting systems with flow control assemblies having adjustable lumens. The flow control assembly can include a body that defines a lumen. The body can include an adjustable portion having an inner width or diameter that is inversely proportional to a fluid resistance of the lumen. The flow control assembly can be configured to transition between one or more configurations, and each configuration can correspond to a different inner width of the adjustable portion. The flow control assembly can be translation-based, such that transitioning the flow control assembly between the one or more configurations can include translating at least part of the flow control assembly.

Abstract: The present technology is directed to implantable medical devices for draining fluid from a first body region to a second body region. Some embodiments of the present technology provide adjustable devices that are selectively titratable to provide various levels of therapy. For example, the adjustable devices can have a drainage element with a lumen extending therethrough, a flow control element, and an actuation assembly. The actuation assembly can drive movement of the flow control element to change a dimension of and/or a flow resistance through the lumen, thereby increasing or decreasing the relative drainage rate of aqueous from an eye. In some embodiments, the actuation assembly and the flow control element together operate as a ratchet mechanism that can selectively move the flow control element between a plurality of positions and lock the device in a desired configuration until further actuation of the actuation assembly.

Abstract: The present technology is generally directed to shunt delivery systems and associated methods for delivering and deploying adjustable shunts. In some embodiments, the delivery systems include a housing, a pair of movement guides positioned within the housing, and an actuation assembly positioned at least partially between the pair of movement guides. The actuation assembly can include an actuator and a pair of arms operably engaged by the actuator. The actuation assembly can be configured to releasably carry a shunt at least partially between the pair of arms. The actuator can be movable relative to the pair of movement guides to cause movement of the pair of arms relative to the housing to, e.g., expose a length of the shunt distally beyond the arms.

Abstract: Disclosed herein are system, method, and computer program product embodiments for a method of cloud infrastructure optimization. The method identifies an existing infrastructure configuration deployed in a cloud environment and generates a plurality of proposal configurations, each of the plurality of proposal configurations having executable code configured to adjust the existing infrastructure configuration for at least one variable. The method selects a proposal configuration from the plurality of proposal configurations based on the at least one variable adjusted for in the existing infrastructure configuration, and the selected proposal configuration is deployed in the cloud environment. The method then analyzes the selected proposal configuration for a level of adjustment for the at least one variable. The method trains a model engine with existing and new training data.

Abstract: A handheld ultrasound device and corresponding methods, including devices and methods used for rejuvenating the vulvovaginal area of the user. In general, the handheld ultrasound devices include a device body coupled to an acoustic coupler and a handle. The device body further includes internal components including an ultrasound transducer, an energy delivery element, and circuitry for controlling the ultrasound output. In particular examples, the methods of using the handheld ultrasound device include engaging the tissue in and around the vulvovaginal area with the energy delivery element, applying ultrasound energy to the vulvovaginal tissue from the energy delivery element and through the acoustic coupler, and affecting a measurable parameter associated with vulvovaginal rejuvenation.

Abstract: The present technology is generally directed to adjustable shunting systems for draining fluid from a first body region to a second body region. The adjustable shunting systems include a flow control plate or cartridge for controlling the flow of fluid through the system. For example, the flow control plate can include a shape memory actuation assembly having one or more nitinol actuators for controlling the flow of fluid through the system. The flow control plate can further include a plurality of discrete sheets or layers adhered together to encase the shape memory actuation assembly. The discrete sheets or layers can form flow channels for directing fluid through the flow control plate.

Abstract: The present technology provides adjustable shunting systems with shape memory actuators. The shape memory actuators can be configured to selectively control the flow of fluid through the shunting system. For example, the shape memory actuators can include an anchor element, a gating element, and first and second actuation elements that extend between the anchor element and the gating element. The first actuation element can be selectively and independently actuated to rotate, pivot, or otherwise move the gating element in a first direction. The second actuation element can also be selectively and independently actuated to rotate, pivot, or otherwise move the gating element in a second direction opposite the first direction. When the shape memory actuator is coupled to the shunting system, the gating element can be positioned to moveably interface with a port or channel that permits fluid to flow into and/or through the shunting system.

Abstract: Disclosed herein are system, method, and computer program product embodiments for a method of cloud infrastructure optimization. The method identifies an existing infrastructure configuration deployed in a cloud environment and generates a plurality of proposal configurations, each of the plurality of proposal configurations having executable code configured to adjust the existing infrastructure configuration for at least one variable. The method selects a proposal configuration from the plurality of proposal configurations based on the at least one variable adjusted for in the existing infrastructure configuration, and the selected proposal configuration is deployed in the cloud environment. The method then analyzes the selected proposal configuration for a level of adjustment for the at least one variable. The method trains a model engine with existing and new training data.

Abstract: The present technology relates to intraocular shunting systems and methods. In some embodiments, the present technology includes intraocular shunting systems that include a drainage element having an inflow portion configured for placement within an anterior chamber of the eye outside of an optical field of view of the patient and an outflow portion configured for placement at a different location of the eye. The system can also include a flow control assembly having a rotational control element operably coupled to the drainage element. The flow control assembly can further include an actuation structure coupled to the rotational control element and configured to selectively change an orientation of the rotational control element. An amount of fluid through the inflow portion and/or the outflow portion can vary based on the selected orientation of the rotational control element.

Abstract: The present technology is directed to implantable medical devices for draining fluid from a first body region to a second body region. Some embodiments of the present technology provide adjustable devices that are selectively titratable to provide various levels of therapy. For example, the adjustable devices can have a drainage element with a lumen extending therethrough, a flow control element, and an actuation assembly. The actuation assembly can drive movement of the flow control element to change a dimension of and/or a flow resistance through the lumen, thereby increasing or decreasing the relative drainage rate of aqueous from an eye. In some embodiments, the actuation assembly and the flow control element together operate as a ratchet mechanism that can selectively move the flow control element between a plurality of positions and lock the device in a desired configuration until further actuation of the actuation assembly.

Abstract: The present technology is generally directed to adjustable shunting systems, including adjustable shunting systems with improved flow control. For example, the adjustable shunting systems described herein can include a flow control plate or other feature with a ramping feature that directs a sealing assembly toward and/or at least partially into an inlet or outlet of a drainage channel to improve the seal between the sealing assembly and the inlet or outlet. In some embodiments, the ramping feature is a slot, groove, or other opening in the plate.

Abstract: The present technology relates to intraocular shunting systems and methods. In some embodiments, the present technology includes intraocular shunting systems that include a drainage element having an inflow portion configured for placement within an anterior chamber of the eye outside of an optical field of view of the patient and an outflow portion configured for placement at a different location of the eye. The system can also include a flow control assembly having a rotational control element operably coupled to the drainage element. The flow control assembly can further include an actuation structure coupled to the rotational control element and configured to selectively change an orientation of the rotational control element. An amount of fluid through the inflow portion and/or the outflow portion can vary based on the selected orientation of the rotational control element.

Abstract: The present technology is generally directed to shunt delivery systems and associated methods for delivering and deploying adjustable shunts. In some embodiments, the delivery systems include a device that can be easily held and manipulated by a physician or other user during an implant procedure. In some embodiments, the delivery system can be configured to facilitate priming of the adjustable shunt, such as before implantation of the adjustable shunt. In at least some embodiments, for example, the delivery system can include one or more priming ports or apertures fluidly coupled to the intraocular shunting system at least when the delivery system is in the first state. Fluid can be introduced into the delivery system via individual ones of the priming ports and flow toward and/or into the adjustable shunt to thereby “prime” the adjustable shunt.

Abstract: The present technology provides microfluidic shunting systems having multiple channels and associated methods of making the same. In some embodiments. the microfluidic shunting systems comprise a plurality of layers or drainage elements that are stacked and adhered together. In some embodiments, individual channels can be positioned in separate layers or drainage elements. and/or can span multiple layers or drainage elements.

Abstract: Provided herein are systems and methods for characterizing one or more additional data profiles in plants or groups of plants. In one embodiment, a supervised learning model is established using one or more data profiles for two or more training plants or groups of training plants. Each plant or group of plants has a different identified phenotype for a phenotype of interest. Further, systems and methods for using the established supervised learning model to accurately predict a phenotype for a phenotype of interest for one or more test plants are also provided.

Abstract: A method for planning and/or optimizing an in-person trip includes: determining, based on a user interaction between a user and a user device, that the user has an in-person-action intention associated with a particular location; obtaining a list of elements designated by the user for in-person action; identifying at least one entity associated with the particular location; determining at least one location at the at least one entity associated with at least one element on the list; generating directions that indicate a path through the at least one entity and to the at least one location associated with the at least one element; receiving an indication from the user device that the user device has determined that the user has arrived at the at least one entity; and in response to receiving the indication, causing the user device to output the directions.

Abstract: The present technology is generally directed to adjustable shunting systems, including adjustable shunting systems having at least two discrete fluid flow paths having different fluid resistances. In at least some embodiments, the shunting systems include an actuator that controls which of the two discrete fluid flow paths is “open” to fluid flow. For example, the actuator can be configured to selectively control the flow of fluid through the system by selectively alternating between (i) opening a first flow path while closing a second flow path, and (ii) opening the second flow path while closing the first flow path.

Abstract: The present technology is generally directed to an adjustable shunting system for draining fluid from a first body region to a second body region. The adjustable shunting system can include a screen assembly configured to at least partially prevent debris from entering an internal portion of the adjustable shunting system. For example, the screen can be at least partially aligned with one or more fluid inlets of the adjustable shunting system. In some embodiments, the adjustable shunting system include one or more actuators that can be actuated via energy. In such embodiments, the screen assembly can be configured such that the actuators are accessible to energy through the screen. In these and other embodiments, the screen can be at least partially cleaned of debris by applying non-invasive ablative energy to the screen.

Abstract: The present technology is generally directed to adjustable shunting systems for draining fluid from a first body region to a second body region. The adjustable shunting systems include a flow control plate or cartridge for controlling the flow of fluid through the system. For example, the flow control plate can include a shape memory actuation assembly having one or more nitinol actuators for controlling the flow of fluid through the system. The flow control plate can further include a plurality of discrete sheets or layers adhered together to encase the shape memory actuation assembly. The discrete sheets or layers can form flow channels for directing fluid through the flow control plate.

Abstract: The present disclosure provides devices, systems and methods for treating eye disorders by delivering ultrasound energy. Specifically, methods for reducing or reversing retinal ganglion nerve layer (RNFL) thinning are provided.