Abstract: The present technology provides microfluidic shunting systems having multiple channels and associated methods of making the same. In some embodiments. the microfluidic shunting systems comprise a plurality of layers or drainage elements that are stacked and adhered together. In some embodiments, individual channels can be positioned in separate layers or drainage elements. and/or can span multiple layers or drainage elements.

Abstract: Provided herein are systems and methods for characterizing one or more additional data profiles in plants or groups of plants. In one embodiment, a supervised learning model is established using one or more data profiles for two or more training plants or groups of training plants. Each plant or group of plants has a different identified phenotype for a phenotype of interest. Further, systems and methods for using the established supervised learning model to accurately predict a phenotype for a phenotype of interest for one or more test plants are also provided.

Abstract: A method for planning and/or optimizing an in-person trip includes: determining, based on a user interaction between a user and a user device, that the user has an in-person-action intention associated with a particular location; obtaining a list of elements designated by the user for in-person action; identifying at least one entity associated with the particular location; determining at least one location at the at least one entity associated with at least one element on the list; generating directions that indicate a path through the at least one entity and to the at least one location associated with the at least one element; receiving an indication from the user device that the user device has determined that the user has arrived at the at least one entity; and in response to receiving the indication, causing the user device to output the directions.

Abstract: The present technology is generally directed to adjustable shunting systems, including adjustable shunting systems having at least two discrete fluid flow paths having different fluid resistances. In at least some embodiments, the shunting systems include an actuator that controls which of the two discrete fluid flow paths is “open” to fluid flow. For example, the actuator can be configured to selectively control the flow of fluid through the system by selectively alternating between (i) opening a first flow path while closing a second flow path, and (ii) opening the second flow path while closing the first flow path.

Abstract: The present technology is generally directed to an adjustable shunting system for draining fluid from a first body region to a second body region. The adjustable shunting system can include a screen assembly configured to at least partially prevent debris from entering an internal portion of the adjustable shunting system. For example, the screen can be at least partially aligned with one or more fluid inlets of the adjustable shunting system. In some embodiments, the adjustable shunting system include one or more actuators that can be actuated via energy. In such embodiments, the screen assembly can be configured such that the actuators are accessible to energy through the screen. In these and other embodiments, the screen can be at least partially cleaned of debris by applying non-invasive ablative energy to the screen.

Abstract: An apparatus for use in manufacturing a component of an implantable medical device comprises a fixture comprising a first fixture member having a plurality of semi-circular recesses in a lower surface thereof, and a second fixture member having a plurality of semi-circular recesses in an upper surface thereof, the first and second fixture members being configured to be selectively fastened together via a plurality of fasteners, wherein in an assembled state of the fixture, each of the semi-circular recesses of the first fixture member lower surface is aligned with an opposing semi-circular recess in the second fixture member upper surface to define a plurality of workpiece openings each dimensioned to receive and secure a respective work piece to be machined to the fixture.

Abstract: The present technology is generally directed to adjustable shunting systems for draining fluid from a first body region to a second body region. The adjustable shunting systems include a flow control plate or cartridge for controlling the flow of fluid through the system. For example, the flow control plate can include a shape memory actuation assembly having one or more nitinol actuators for controlling the flow of fluid through the system. The flow control plate can further include a plurality of discrete sheets or layers adhered together to encase the shape memory actuation assembly. The discrete sheets or layers can form flow channels for directing fluid through the flow control plate.

Abstract: The present disclosure provides devices, systems and methods for treating eye disorders by delivering ultrasound energy. Specifically, methods for reducing or reversing retinal ganglion nerve layer (RNFL) thinning are provided.

Abstract: The present technology is generally directed to adjustable shunting systems for draining fluid from a first body region to a second body region. The adjustable shunting systems include an actuation assembly for controlling the flow of fluid through the system. For example, the actuation assembly can include one or more fluid inlets in fluid communication with an environment external to the system. The actuation assembly can further include one or more actuators configured to move a corresponding control element to control the flow of fluid through the fluid inlets. The actuator can also have a first actuation element and a second actuation element configured to move the control element between a first position in which the control element substantially prevents fluid flow through the corresponding inlet and a second position in which the control element does not substantially prevent fluid flow through the fluid inlets.

Abstract: The present technology is generally directed to shunting systems, including shunting systems having a shapeable/conformable elongated housing or shunting element that can be contoured or otherwise selectively shaped to improve a fit with patient anatomy. The shunting systems and elongated housings described herein can have numerous other advantageous features expected to improve the operation of shunting systems, such as beveled leading edges, lateral outlets, suture rings, positioning appendages, and the like.

Abstract: Disclosed herein are system, method, and computer program product embodiments for a method of cloud infrastructure optimization. The method identifies an existing infrastructure configuration deployed in a cloud environment and generates a plurality of proposal configurations, each of the plurality of proposal configurations having executable code configured to adjust the existing infrastructure configuration for at least one variable. The method selects a proposal configuration from the plurality of proposal configurations based on the at least one variable adjusted for in the existing infrastructure configuration, and the selected proposal configuration is deployed in the cloud environment. The method then analyzes the selected proposal configuration for a level of adjustment for the at least one variable. The method trains a model engine with existing and new training data.

Abstract: The present technology is directed to adjustable shunting systems for draining fluid from a first body region to a second body region, and can include a shunting element, an aperture in the shunting element, and an actuator for selectively controlling the flow of fluid through the aperture. The actuator can include a gating element moveable between a first position in which it does not substantially interfere with fluid flow through the aperture and a second position in which it at least partially blocks fluid flow through the aperture, and a shape memory actuation element configured to move the gating element from the first position to and/or toward the second position when actuated. The system can further include a friction element configured to frictionally engage the gating element to releasably retain the gating element at and/or proximate the second position following actuation of the shape memory actuation element.

Abstract: A handheld ultrasound device and corresponding methods used for rejuvenating the vulvovaginal area of the user. In general, the handheld ultrasound devices include a device body coupled to an acoustic coupler and a handle. The device body further includes internal components including an ultrasound transducer, an energy delivery element, and circuitry for controlling the ultrasound output. The methods of using the handheld ultrasound device include engaging the tissue in and around the vulvovaginal area with the energy delivery element, applying ultrasound energy to the vulvovaginal tissue from the energy delivery element and through the acoustic coupler, and affecting a measurable parameter associated with vulvovaginal rejuvenation.