Abstract: This disclosure provides methods and devices for determining a quantitative estimate of thrombomodulin levels in a mammalian subject suspected of internal hemorrhaging. The method includes applying a blood sample from the subject to a handheld assay device capable of providing optical quantitation of the amount of thrombomodulin in the sample, measuring, by means of said assay device, an analyte signal value correlated to a concentration of the thrombomodulin in the blood sample and comparing the analyte signal value to a minimum threshold, wherein an analyte signal value less than the minimum threshold indicates that the subject is not internally hemorrhaging, and an analyte signal value above the minimum threshold indicates the subject is internally hemorrhaging. The methods and devices are adapted to rapidly assess internal hemorrhaging and hemorrhagic shock in a patient outside of hospital settings.

Abstract: Provided are prodrugs of various therapeutic agents that provide enhanced bioavailability of the therapeutic agent, and methods of treatment conditions in a subject by administration of the one or prodrugs. As provided herein a prodrug includes a therapeutic agent covalently attached to a cap, the cap having a structure according to formula (I) where: R1 is a branched or linear substituted or unsubstituted C2-C6 alkyl, alkenyl, or alkynl; X is —S(0)2-; R2 is a branched or linear substituted or unsubstituted C4-C20 alkyl, alkenyl, or alkynyl; and R3 is —H, C3-C5 cycloalkyl, C3-C5 cycloheteroalkyl, —C(CH3)3, —CF3, —C(CF3)3, or a substituted or unsubstituted phenyl.

Abstract: Some embodiments provide a system and method to receive, as an input, configuration properties of a group of operators of a data pipeline, the data pipeline including a specified multiplicity greater than one (1); generate, as an output, a configuration for two new operators, including a first new operator and a second new operator; and automatically insert the first new operator and the second new operator into a deployment of the data pipeline, the first new operator being inserted before a number of replicas of the group of operators of the data pipeline corresponding to the specified multiplicity and the second new operator being inserted after the number of replicas of the group of operators of the data pipeline corresponding to the specified multiplicity.

Abstract: This disclosure provides methods and devices for determining a quantitative estimate of syndecan-1 levels in a mammalian subject suspected of internal hemorrhaging. The method includes applying a blood sample from the subject to a hand-held assay device capable of providing optical quantitation of the amount of syndecan-1 in the sample, measuring, by means of said assay device, an analyte signal value correlated to a concentration of the syndecan-1 in the blood sample and comparing the analyte signal value to a minimum threshold, wherein an analyte signal value less than the minimum threshold indicates that the subject is not internally hemorrhaging, and an analyte signal value above the minimum threshold indicates the subject is internally hemorrhaging. The methods and devices are adapted to rapidly assess internal hemorrhaging and hemorrhagic shock in a patient outside of hospital settings.

Abstract: This invention relates to oral care compositions with improved foaming properties which comprise a basic amino acid, an abrasive and a taurate surfactant, as well as to methods of using these compositions. Optionally, the oral care compositions further comprise an alkyl polyglucoside.

Abstract: A cricothyrotomy device comprises an incision member and an insertion member that are joined together but separable. The incision member further comprises a scalpel, a scalpel cap, a spring assembly, and an incision holder. The insertion member comprises a cannula, a cannula cap, and an insertion handle.

Abstract: Some embodiments provide a system and method to receive, as an input, configuration properties of a group of operators of a data pipeline, the data pipeline including a specified multiplicity greater than one (1); generate, as an output, a configuration for two new operators, including a first new operator and a second new operator; and automatically insert the first new operator and the second new operator into a deployment of the data pipeline, the first new operator being inserted before a number of replicas of the group of operators of the data pipeline corresponding to the specified multiplicity and the second new operator being inserted after the number of replicas of the group of operators of the data pipeline corresponding to the specified multiplicity.

Abstract: An oral care composition and methods for the same are disclosed herein. The oral care composition may include an orally acceptable vehicle, an anionic surfactant, and a nonionic surfactant. The anionic surfactant may include a C6-C18 fatty acid glutamate or a salt thereof, and the nonionic surfactant may include a C6-C18 alkyl polyglucoside. A weight ratio of the nonionic surfactant to the anionic surfactant may be from about 0.25:1 to about 9:1, or from about 1.8:1 to about 2.2:1.

Abstract: Computer-readable media, methods, and systems are disclosed for performing rollback recovery with data lineage capture for data pipelines. A middle operator receives ingested input events from a source operator reading data from an external input data source. The middle operator then logs information regarding middle input events to a middle operator input log, designating the logged middle input event information as incomplete. The middle operator then processes data associated with the middle input events and updates the middle input log entries setting them to a completed logging status designation for middle input events that were consumed to produce the one or more middle output events. The middle operator then transmits the middle output events to subsequent operators. Garbage collection is performed to remove completed entries from the middle operator output log. Finally, based on receiving a recovering message from a subsequent operator, corresponding middle output events are re-sent.

Abstract: Computer-readable media, methods, and systems are disclosed for performing rollback recovery with data lineage capture for data pipelines. A middle operator receives ingested input events from a source operator reading data from an external input data source. The middle operator then logs information regarding middle input events to a middle operator input log, designating the logged middle input event information as incomplete. The middle operator then processes data associated with the middle input events and updates the middle input log entries setting them to a completed logging status designation for middle input events that were consumed to produce the one or more middle output events. The middle operator then transmits the middle output events to subsequent operators. Garbage collection is performed to remove completed entries from the middle operator output log. Finally, based on receiving a recovering message from a subsequent operator, corresponding middle output events are re-sent.

Abstract: This disclosure provides methods and devices for determining a quantitative estimate of syndecan-1 levels in a mammalian subject suspected of internal hemorrhaging. The method includes applying a blood sample from the subject to a hand-held assay device capable of providing optical quantitation of the amount of syndecan-1 in the sample, measuring, by means of said assay device, an analyte signal value correlated to a concentration of the syndecan-1 in the blood sample and comparing the analyte signal value to a minimum threshold, wherein an analyte signal value less than the minimum threshold indicates that the subject is not internally hemorrhaging, and an analyte signal value above the minimum threshold indicates the subject is internally hemorrhaging. The methods and devices are adapted to rapidly assess internal hemorrhaging and hemorrhagic shock in a patient outside of hospital settings.

Abstract: A method includes retrieving a plurality of indications of cardiac events in a patient, heart rates of the patient during the cardiac events, and durations of the cardiac events. The method also includes selecting a subset of indications from the plurality of indications based on the heart rates of the patient during the cardiac events and the durations of the cardiac events and sorting the subset of indications based on heart rates of the patient during the cardiac event indicated by the subset of indications and based on durations of the cardiac events indicated by the subset of indications to produce a sorted list of indications. The method further includes communicating, from the sorted list, an indication that is first in the sorted list for clinical review.

Abstract: The invention relates mainly to a rotary electric machine for a motor vehicle. The machine (10) comprises a shaft (13); a rotor (12); a stator (16) comprising a body (25) provided with slots, and a winding (26) inserted into the slots; a first bearing (37) and a second bearing (38) surrounding an assembly formed by the rotor and the stator and each comprising a housing (40, 44) for rotatably mounting the rotor shaft (13). The first bearing comprises a transverse flange (371) and a cylindrical wall (372) of axial orientation derived from an outer periphery of said flange. The second bearing comprises a transverse flange (48) closing the first bearing and at least one rim (63) projecting from the flange and forming a junction area (64) where it joins the first bearing. Furthermore, the stator body has a region (Z1) of shrink-fitting to the cylindrical wall.

Abstract: Provided are prodrugs of various therapeutic agents that provide enhanced bioavailability of the therapeutic agent, and methods of treatment conditions in a subject by administration of the one or prodrugs. As provided herein a prodrug includes a therapeutic agent covalently attached to a cap, the cap having a structure according to formula (I) where: R1 is a branched or linear substituted or unsubstituted C2-C6 alkyl, alkenyl, or alkynl; X is —S(0)2-; R2 is a branched or linear substituted or unsubstituted C4-C20 alkyl, alkenyl, or alkynyl; and R3 is —H, C3-C5 cycloalkyl, C3-C5 cycloheteroalkyl, —C(CH3)3, —CF3, —C(CF3)3, or a substituted or unsubstituted phenyl.

Abstract: A cricothyrotomy device comprises an incision member and an insertion member that are joined together but separable. The incision member further comprises a scalpel, a scalpel cap, a spring assembly, and an incision holder. The insertion member comprises a cannula, a cannula cap, and an insertion handle.

Abstract: An oral care composition and methods for the same are disclosed herein. The oral care composition may include an orally acceptable vehicle, an anionic surfactant, and a nonionic surfactant. The anionic surfactant may include a C6-C18 fatty acid glutamate or a salt thereof, and the nonionic surfactant may include a C6-C18 alkyl polyglucoside. A weight ratio of the nonionic surfactant to the anionic surfactant may be from about 0.25:1 to about 9:1, or from about 1.8:1 to about 2.2:1.

Abstract: This invention relates to oral care compositions with improved foaming properties which comprise a basic amino acid, an abrasive and a taurate surfactant, as well as to methods of using these compositions. Optionally, the oral care compositions further comprise an alkyl polyglucoside.

Abstract: The invention provides oral care compositions, for example a dentifrice or mouthwash, comprising zinc phosphate, wherein the zinc phosphate is added to the dentifrice or mouthwash as a preformed salt; as well as methods of making and using the same.

Abstract: An oral care composition and methods for the same are disclosed herein. The oral care composition may include an orally acceptable vehicle, an anionic surfactant, and a nonionic surfactant. The anionic surfactant may include a C6-C18 fatty acid glutamate or a salt thereof, and the nonionic surfactant may include a C6-C18 alkyl polyglucoside. A weight ratio of the nonionic surfactant to the anionic surfactant may be from about 0.25:1 to about 9:1, or from about 1.8:1 to about 2.2:1.

Abstract: According to one aspect, the present description relates to a drone designed for viewing a distant scene, comprising a flying platform and at least one first camera mechanically secured to the platform. The first camera comprises an image sensor with a detection surface, an electro-optical system for forming images of the scene on the detection surface of the image sensor, able to give the camera a dimensional angular field of view of less than 47°. According to the first aspect, the electro-optical system comprises at least one first optical group, which is fixed, comprising a plurality of optical diopters, an electro-optical device with variable optical power able to adjust the focusing of the image on the detection surface, and a control unit controlling the electro-optical device.