Patents by Inventor Eric Simone

Eric Simone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHARMACEUTICAL FORMULATION
    Publication number: 20230338283
    Abstract: Disclosed is a pharmaceutical mini-tablet comprising mitapivat or a pharmaceutically acceptable salt thereof, and in a particular embodiment comprising a mitapivat sulfate salt, and one or more inactive ingredients selected from a filler, disintegrant, lubricant, binder, and diluent.
    Type: Application
    Filed: September 24, 2021
    Publication date: October 26, 2023
    Inventors: Cheuk-Yui Leung, Eric Simone, Ophelia Qiping Yin
  • FORMULATIONS OF THIOPHENE COMPOUNDS
    Publication number: 20140235705
    Abstract: A pharmaceutical composition comprises: a) polymorphic form M or tromethamine salt of Compound (1) represented by the following structural formula: and b) a filler. A method of preparing a pharmaceutical composition comprises: providing a mixture of Compound (1) and a filler to form the composition of Compound (1). A method of treating a HCV infection in a subject comprises administering to the subject a therapeutically effective amount of the pharmaceutical composition.
    Type: Application
    Filed: January 24, 2014
    Publication date: August 21, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Nicholas Cardoso, Chong-Hui Gu, Peter A. Ojakovo, Tapan Sanghvi, Eric A. Simone, Marinus J. Verwijs
  • Method and compositions for polymer nanocarriers containing therapeutic molecules
    Patent number: 8568786
    Abstract: A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The primary emulsion is formed using a freeze-thaw cycle of the amphiphilic diblock copolymer and a protein having a molecular weight of up to or equal to 300,000 Da. Selection of the hydrophobic polymer block percentage alters one or more characteristics of the resulting nanoparticles, such as shape. Thus, as one aspect, a method of producing filamentous polymeric nanocarrier-encapsulated protein (i.e.
    Type: Grant
    Filed: October 27, 2008
    Date of Patent: October 29, 2013
    Assignee: The Trustees of the Universtiy of Pennsylvania
    Inventors: Eric Simone, Vladimir R. Muzykantov, Thomas D. Dziubla
  • Method and compositions for polymer nanocarriers containing therapeutic molecules
    Patent number: 7927629
    Abstract: A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The primary emulsion is formed using a freeze-thaw cycle of the amphiphilic diblock copolymer and a protein having a molecular weight of up to or equal to 300,000 Da. Selection of the hydrophobic polymer block percentage alters one or more characteristics of the resulting nanoparticles, such as shape. Thus, as one aspect, a method of producing filamentous polymeric nanocarrier-encapsulated protein (i.e.
    Type: Grant
    Filed: October 27, 2007
    Date of Patent: April 19, 2011
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Eric Simone, Vladimir R. Muzykantov, Thomas D. Dziubla
  • Method and Compositions for Polymer Nanocarriers Containing Therapeutic Molecules
    Publication number: 20100316571
    Abstract: A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The primary emulsion is formed using a freeze-thaw cycle of the amphiphilic diblock copolymer and a protein having a molecular weight of up to or equal to 300,000 Da. Selection of the hydrophobic polymer block percentage alters one or more characteristics of the resulting nanoparticles, such as shape. Thus, as one aspect, a method of producing filamentous polymeric nanocarrier-encapsulated protein (i.e.
    Type: Application
    Filed: October 27, 2008
    Publication date: December 16, 2010
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Eric Simone, Vladimir R. Muzykantov, Thomas D. Dziubla
  • METHOD AND COMPOSITIONS FOR POLYMER NANOCARRIERS CONTAINING THERAPEUTIC MOLECULES
    Publication number: 20090110741
    Abstract: A method of controlling a physical characteristic of polymeric nanocarrier-encapsulated protein particles includes altering or selecting a weight percentage of a hydrophobic polymer block in a total amphiphilic diblock copolymer of a primary emulsion of a double emulsion, freeze-thaw technique. The primary emulsion is formed using a freeze-thaw cycle of the amphiphilic diblock copolymer and a protein having a molecular weight of up to or equal to 300,000 Da. Selection of the hydrophobic polymer block percentage alters one or more characteristics of the resulting nanoparticles, such as shape. Thus, as one aspect, a method of producing filamentous polymeric nanocarrier-encapsulated protein (i.e.
    Type: Application
    Filed: October 27, 2007
    Publication date: April 30, 2009
    Applicant: The Trustees of the University of Pennsylvania
    Inventors: Eric Simone, Vladimir R. Muzykantov, Thomas D. Dziubla