Patents by Inventor Eric Skaar

Eric Skaar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human monoclonal antibodies to Isd proteins and uses thereof
    Patent number: 11992520
    Abstract: The present disclosure is directed to antibodies binding to and inhibiting S. aureus and methods for use thereof.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: May 28, 2024
    Assignee: VANDERBILT UNIVERSITY
    Inventors: James E. Crowe, Jr., Eric Skaar
  • COMBINATION OF INTRACELLULAR AND EXTRACELLULAR PHOTOSENSITIZERS FOR TREATMENT OF BACTERIAL INFECTION
    Publication number: 20240131356
    Abstract: A method of inducing death or inhibiting growth or reproduction of a Gram-positive bacterial cell involves contacting the bacterial cell with a coproporphyrinogen oxidase (CgoX) activator, thereby promoting accumulation of coproporphyrin III (CPIII) in the bacterial cell, where the CPIII serves as an intracellular photosensitizer; contacting the bacterial cell with a photosensitizer conjugated to an iron-regulated surface determinant (Isd) protein targeting moiety, which Isd proteins are expressed on the service of the bacterial cell such that the conjugated photosensitizer serves as an extracellular photo sensitizer; exposing the bacterial cell to light having a first excitation wavelength of the intracellular photo sensitizer; and exposing the bacterial cell to light having a second excitation wavelength of the extracellular photosensitizer.
    Type: Application
    Filed: January 27, 2022
    Publication date: April 25, 2024
    Inventor: Eric Skaar
  • HUMAN MONOCLONAL ANTIBODIES TO STAPHYLOCOCCAL AUREUS ISD PROTEINS AND USES THEREOF
    Publication number: 20220080036
    Abstract: The present disclosure is directed to antibodies binding to and inhibiting S. aureus and methods for use thereof.
    Type: Application
    Filed: September 6, 2019
    Publication date: March 17, 2022
    Inventors: James E. Crowe, Jr., Eric Skaar
  • High-throughput, multi-omics approach to determine and validate de novo global mechanisms of action for drugs and toxins
    Patent number: 10607721
    Abstract: The present disclosure provides for rapid identification of mechanism of action (MOA) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: March 31, 2020
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Richard Caprioli, John Wikswo, John McLean, Eric Skaar, Jeremy L. Norris, Dana Borden Lacy, Stacy Sherrod, James Pino, Danielle Gutierrez, Nicole D. Muszynski, Melissa Farrow
  • HIGH-THROUGHPUT, MULTI-OMICS APPROACH TO DETERMINE AND VALIDATE DE NOVO GLOBAL MECHANISMS OF ACTION FOR DRUGS AND TOXINS
    Publication number: 20170082606
    Abstract: The present disclosure provides for rapid identification of mechanism of action (MOA) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.
    Type: Application
    Filed: September 22, 2016
    Publication date: March 23, 2017
    Applicant: Vanderbilt University
    Inventors: Richard CAPRIOLI, John WIKSWO, John MCLEAN, Eric SKAAR, Jeremy L. Norris
  • Method for treating microbial infections
    Patent number: 8916163
    Abstract: A method for treating a microbial infection or an abscessed tissue in a subject includes administering to the subject an effective amount of a metal ion chelator. In some embodiments, the metal ion chelator can be a protein, such as a calprotectin heterodimer. In some embodiments, the metal ion chelator is a calprotectin heterodimer including an S100A8 polypeptide and an S100A9 polypeptide.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: December 23, 2014
    Assignee: Vanderbilt University
    Inventors: Eric Skaar, Brian Corbin
  • Antimicrobial compounds and methods of use thereof
    Patent number: 8263642
    Abstract: In one aspect, the invention relates to compounds and methods useful for activating heme sensor systems; for decreasing virulence of bacteria, for example, Staphylococcus aureus; pharmaceutical compositions comprising the compounds; and methods of treating microbial-related disorders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: September 11, 2012
    Assignee: Vanderbilt University
    Inventors: Eric Skaar, Devin Stauff, Olusegun O. Aranmolate
  • ANTIMICROBIAL COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20100004324
    Abstract: In one aspect, the invention relates to compounds and methods useful for activating heme sensor systems; for decreasing virulence of bacteria, for example, Staphylococcus aureus; pharmaceutical compositions comprising the compounds; and methods of treating microbial-related disorders. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: June 25, 2009
    Publication date: January 7, 2010
    Inventors: Eric Skaar, Devin Stauff, Olusegun O. Aranmolate