Abstract: Aspects described herein may relate to a transaction exchange platform using a streaming data platform (SDP) and microservices to process transactions according to review and approval workflows. The transaction exchange platform may receive transactions from origination sources, which may be added to the SDP as transaction objects. As the transactions are received, the transactions may be analyzed to detect duplicate transactions and/or errors in the transactions. The transaction exchange platform may take steps to remediate transactions that are recognized as duplicates or predicted to generate one or more errors. Similarly, the transaction exchange platform may take steps to remediate transactions that are rejected by a clearinghouse.

Abstract: Aspects described herein may relate to a transaction exchange platform using a streaming data platform (SDP) and microservices to process transactions according to review and approval workflows. The transaction exchange platform may receive transactions from origination sources, which may be added to the SDP as transaction objects. As the transactions are received, the transactions may be analyzed to detect duplicate transactions and/or errors in the transactions. The transaction exchange platform may take steps to remediate transactions that are recognized as duplicates or predicted to generate one or more errors. Similarly, the transaction exchange platform may take steps to remediate transactions that are rejected by a clearinghouse.

Abstract: Various embodiments relate generally to data science and data analysis, computer software and systems, to provide a platform to facilitate updating compatible distributed data files, among other things, and, more specifically, to a computing and data platform that implements logic to facilitate correlation of event data via analysis of electronic messages, including executable instructions and content, etc., via a cross-stream data processor application configured to, for example, update or modify one or more compatible distributed data files automatically.

Abstract: A medical system may include: a medical device including an elongate shaft configured to access a treatment site within a patient and a handle coupled to a proximal end of the elongate shaft; a laser device including an elongate tubular member configured for insertion through a working lumen of the medical device, the elongate tubular member including a cooling channel and a laser fiber extending distally within the cooling channel; and a fluid management system including an inflow pump configured to pump fluid from a first fluid supply source through the elongate shaft to the treatment site, a cooling pump configured to pump fluid from a second fluid supply source through the cooling channel, and a controller configured to control the inflow pump and the cooling pump.

Abstract: Systems and methods for an electric axle. The electric axle includes, in one example, a first electric machine directly coupled to a sun gear of a planetary gear set and a second electric machine directly coupled to a carrier of a planetary gear set. The planetary gear set includes a set of planet gears that rotate on the carrier and an output gear that meshes with an input gear in a differential.

Abstract: This invention relates to modules and automated, integrated, end-to-end closed instruments for automated mammalian cell growth and mammalian cell transfection followed by nucleic acid-guided nuclease editing in live mammalian cells.

Abstract: A grill rack system includes at least one grill rack, a left-hand grill bracket, and a right-hand grill bracket. In one embodiment, the grill brackets each include only one set bolt. In an alternative embodiment, each of the grill brackets includes at least one rack track guide defining a rack track guide opening. In an alternative embodiment, the grill rack includes at least one rear crossmember alignment tab. The grill brackets each include at least one rack track guide each defining rack track guide opening and each including the at least one alignment tab disposed in the at least one rack track guide.

Abstract: Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.

Abstract: Systems, methods, and computer-readable storage devices to enable virtual API technology embodied in an SDK for use within a mobile application, a mobile payment wallet, or a mobile operating system.

Abstract: The present disclosure relates to IL2 agonists with improved therapeutic profiles.

Abstract: A computing system comprising a central processing unit (CPU), and memory coupled to the CPU and having stored therein instructions that, when executed by the computing system, cause the computing system to execute operations to generate a radiation treatment plan. The operations include accessing a minimum prescribed dose to be delivered into and across the target, determining a number of beams and directions of the beams, and determining a beam energy for each of the beams, wherein the number of beams, the directions of the beams, and the beam energy for each of the beams are determined such that the entire target receives the minimum prescribed dose. A quantitative time-dependent model-based charged particle pencil beam scanning optimization is then implemented for FLASH therapy.

Abstract: A pulsatile fluid pump system includes a pump-valving assembly including a chamber and a diaphragm assembly coupled to the chamber and including a flexible diaphragm. The diaphragm assembly and the pump-valving assembly are configured as an integral pump assembly. The system further includes a linear motor having a magnet and a coil, the magnet moving in relation to the coil, the coil having an electrical input. The system also includes a control housing rigidly coupled to the linear motor and a controller system having an electrical output coupled to the electrical input of the coil, the controller system defining an electrical waveform at the electrical output to cause desired operation of the diaphragm. The integral pump assembly is configured to be removably coupled to the control housing, and the diaphragm assembly of the integral pump assembly is configured to be removably coupled to the linear motor.

Abstract: Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.

Abstract: An electrified fire fighting vehicle includes a chassis, a cab coupled to the chassis, a body coupled to the chassis, a pump system, and a driveline. The driveline includes a front axle coupled to the chassis, a rear axle coupled to the chassis, an energy storage system, an engine coupled to the chassis, and an electromechanical device coupled to the chassis, the engine, and at least one of the front axle or the rear axle. The driveline is a dual drive driveline such that, during any and all modes of operation of the driveline, the electromechanical device is incapable of or prevented from charging the energy storage system at any time when driven by the engine.

Abstract: Disclosed herein are systems and methods for registering a first three-dimensional medical image dataset taken with a first image capturing device with a second 3D dataset taken with a second image capturing device.

Abstract: The present invention provides multispecific antigen-binding molecules that bind both a T-cell antigen (e.g., CD3) and a target antigen (e.g., a tumor associated antigen, a viral or bacterial antigen), and which include a single polypeptide chain that is multivalent (e.g., bivalent) with respect to T-cell antigen binding, and uses thereof.

Abstract: Aspects of the disclosure are directed toward intelligently selecting the operating parameters of wireless access points (WAPs) deployed in a wireless environment so as to minimize or at least reduce interference in that wireless environment. A WAP may continually measure characteristics of wireless channels used in the wireless environment and obtain measurements of channel metrics for those channels. The WAP analyzes the channel metric history to identify correlations between the channel metric measurements and various timeframes and selects one or more of its operating parameters based on the channel metric history and the correlations identified.

Abstract: Aspects described herein may relate to a transaction exchange platform using a streaming data platform (SDP) and microservices to process transactions according to review and approval workflows. The transaction exchange platform may receive transactions from origination sources, which may be added to the SDP as transaction objects. As the transactions are received, the transactions may be analyzed to detect duplicate transactions and/or errors in the transactions. The transaction exchange platform may take steps to remediate transactions that are recognized as duplicates or predicted to generate one or more errors. Similarly, the transaction exchange platform may take steps to remediate transactions that are rejected by a clearinghouse.

Abstract: As described herein, a N-Gram index may be created and the search may be conducted using the index, which will lead to faster search results. The N-Gram index may also include partial N-Gram components to capture more relevant data. Moreover, as described herein, the search may also take into account recent log data that has not yet been indexed. Techniques for building an index store using log data and efficiently searching the index store and log data to process search requests are described herein.