Abstract: Provided herein is a pharmaceutical combination comprising (a) a poly-(ADP-ribose)-polymerase (PARP) inhibitor and (b) a second agent comprising (i) an inhibitor of glycogen synthase kinase 3 (GSK-3) or (ii) an inhibitor of disrupter of telomeric silencing 1-like (DOT1L). Also provided is a method of treating a subject suffering from acute myeloid leukaemia, comprising administering to the subject a therapeutically effective amount of the pharmaceutical combination.

Abstract: Provided herein is a pharmaceutical combination comprising (a) a poly-(ADP-ribose)-polymerase (PARP) inhibitor and (b) a second agent comprising (i) an inhibitor of glycogen synthase kinase 3 (GSK-3) or (ii) an inhibitor of disrupter of telomeric silencing 1-like (DOT1L). Also provided is a method of treating a subject suffering from acute myeloid leukaemia, comprising administering to the subject a therapeutically effective amount of the pharmaceutical combination.

Abstract: Provided herein is a pharmaceutical combination comprising (a) a poly-(ADP-ribose)-polymerase (PARP) inhibitor and (b) a second agent comprising (i) an inhibitor of glycogen synthase kinase 3 (GSK-3) or (ii) an inhibitor of disrupter of telomeric silencing 1-like (DOT1L). Also provided is a method of treating a subject suffering from acute myeloid leukaemia, comprising administering to the subject a therapeutically effective amount of the pharmaceutical combination.

Abstract: A mounting system is provided herein. The mounting system having: a plurality of wall mounts for releasably securing a plurality of items to a vertical surface; and a template having a plurality of cutouts located in a plurality of locations on the template, wherein the plurality of cutouts of the template are each configured to receive at least a portion of one of the plurality of wall mounts therein.

Abstract: In one aspect, there is provided a method for predicting responsiveness of a subject to a poly-(ADP-ribose)-polymerase (PARP) inhibitor for treating acute myeloid leukaemia (AML), the method comprising determining whether a chromosomal abnormality selected from t(8;21), t(15;17), t(16;16) and inv(16) is present in a sample obtained from the subject; wherein the presence of the chromosomal abnormality is indicative of responsiveness of the subject to the PARP inhibitor for treating AML.

Abstract: A mounting system is provided herein. The mounting system having: a plurality of wall mounts for releasably securing a plurality of items to a vertical surface; and a template having a plurality of cutouts located in a plurality of locations on the template, wherein the plurality of cutouts of the template are each configured to receive at least a portion of one of the plurality of wall mounts therein.

Abstract: A track set configured to be mounted to a wall by a plurality of wall mounts, the track set having: a tower: a first upper track section configured to receive toy vehicles from a top portion of the tower; a second lower track section, wherein the first upper track section is angularly positioned such that toy vehicles traveling along the first track section move towards a second lower track section, wherein the second lower track section is configured to direct the toy vehicles towards a bottom portion of a tower; a corkscrew rotationally secured to the tower; and a motor coupled to the corkscrew, wherein operation of the motor causes the corkscrew to rotate, wherein rotation of the corkscrew causes the toy vehicles to move from the bottom portion of the tower to the top portion of the tower.

Abstract: A toy vehicle includes a vehicle body configured for moving along a support surface when disposed in a first orientation. A platform is rotatably coupled to an underside of the vehicle body, and a lever is pivotally coupled to the platform. The lever is movable between a first position disengaged from the support surface and a second position engageable with the support surface when the vehicle is disposed in its first orientation. The lever causes the vehicle to be overturned from its first orientation when the lever is moved from its first position to its second position.

Abstract: A track set configured to be mounted to a wall by a plurality of wall mounts, the track set having: a tower: a first upper track section configured to receive toy vehicles from a top portion of the tower; a second lower track section, wherein the first upper track section is angularly positioned such that toy vehicles traveling along the first track section move towards a second lower track section, wherein the second lower track section is configured to direct the toy vehicles towards a bottom portion of a tower; a corkscrew rotationally secured to the tower; and a motor coupled to the corkscrew, wherein operation of the motor causes the corkscrew to rotate, wherein rotation of the corkscrew causes the toy vehicles to move from the bottom portion of the tower to the top portion of the tower.

Abstract: A track set and a plurality of wall mounts is disclosed herein, each of the plurality of wall mounts having: a planar member; a mount member configured to be snap fittingly engaged into the planar member; wherein the mount member is configured to releasably engage a front surface of the planar member and wherein the front surface of planar member further comprises a ledge portion that is configured to engage a bottom portion of the mount member and a1 feature that is configured to engage an upper portion of the mount member. The track set having a first track segment configured to engage at least one of the plurality of wall mounts and direct an object in a first direction generally down the first track segment; and a U-turn device configured to receive the object from the first track segment and redirect the object it in a direction substantially opposite to the first direction down a second track segment.

Abstract: A toy vehicle includes a vehicle body configured for moving along a support surface when disposed in a first orientation. A platform is rotatably coupled to an underside of the vehicle body, and a lever is pivotally coupled to the platform. The lever is movable between a first position disengaged from the support surface and a second position engageable with the support surface when the vehicle is disposed in its first orientation. The lever causes the vehicle to be overturned from its first orientation when the lever is moved from its first position to its second position.

Abstract: Embodiments of the present invention provide a unique capability of implementing a pair of pseudo-PHY interfaces using a bridge. From the host and device perspectives, the host and device communicate through a PHY interface. The bridge, however, avoids actually using a USB PHY interface. This PHY-less bridge allows communication between a host and a device at high speeds without high-power transceivers associated with a USB PHY interface. In accordance with the present invention, a host and a device may be coupled together using a PHY-less bridge using the same interface or translating between different interfaces by using a wrapper. Such PHY-less bridges include a UTMI-to-UTMI bridge, a UTMI-to-ULPI bridge, a ULPI-to-UTMI bridge and a ULPI-to-ULPI bridge, each avoiding the need for a USB PHY interface.

Abstract: A track set and a plurality of wall mounts is disclosed herein, each of the plurality of wall mounts having: a planar member; a mount member configured to be snap fittingly engaged into the planar member; wherein the mount member is configured to releasably engage a front surface of the planar member and wherein the front surface of planar member further comprises a ledge portion that is configured to engage a bottom portion of the mount member and a feature that is configured to engage an upper portion of the mount member. The track set having a first track segment configured to engage at least one of the plurality of wall mounts and direct an object in a first direction generally down the first track segment; and a U-turn device configured to receive the object from the first track segment and redirect the object it in a direction substantially opposite to the first direction down a second track segment.

Abstract: A toy vehicle play set may include a toy vehicle and a track assembly including a track along which the vehicle may travel. In some examples the vehicle may include a drive mechanism that is adjustable for changing the speed of the vehicle, and a play set may include a speed changer for selectively changing the vehicle speed. In some examples, the track assembly may include a selectively actuated trapdoor in the track. In some examples, the play set may include a vehicle trap assembly having a cover defining a chamber for receiving, for example, a vehicle passing through the trapdoor opening. In some examples, the vehicle trap may include an assembly, such as the vehicle trap that falls apart when contacted by a vehicle traveling along the track.

Abstract: The present disclosure is directed to a toy play set for use with a toy vehicle comprising a platform attached to a support structure. In some examples, the play set may include a base and a support structure pivotally attached to the base with the support structure adapted to pivot relative to the base. In other examples, the toy play set may include a platform pivotally attached to the support structure and adapted to rotate in a toy vehicle's direction of travel. In still other examples, the toy play set may include first and second elongate tracks and means for carrying a toy vehicle from the first elongate track to the second elongate track. One disclosed embodiment includes first and second elongate tracks, a base, a support structure pivotally attached to the base, a platform pivotally attached to the support structure wherein the platform and support structure pivot at perpendicular axes that are parallel to the ground, and a vehicle receiving apparatus attached to the second elongate track.

Abstract: In some examples, a toy vehicle play set may include an elongate track having a first vehicle-support surface defining a travel path, and a carriage mounted for travel along the travel path and having a second vehicle-support surface. The first and second vehicle-support surfaces may be configured to support, in combination, a toy vehicle.

Abstract: Embodiments of the present invention provide a unique capability of implementing a pair of pseudo-PHY interfaces using a bridge. From the host and device perspectives, the host and device communicate through a PHY interface. The bridge, however, avoids actually using a USB PHY interface. This PHY-less bridge allows communication between a host and a device at high speeds without high-power transceivers associated with a USB PHY interface. In accordance with the present invention, a host and a device may be coupled together using a PHY-less bridge using the same interface or translating between different interfaces by using a wrapper. Such PHY-less bridges include a UTMI-to-UTMI bridge, a UTMI-to-ULPI bridge, a ULPI-to-UTMI bridge and a ULPI-to-ULPI bridge, each avoiding the need for a USB PHY interface.

Abstract: In some examples, a toy vehicle play set may include an elongate track having a first vehicle-support surface defining a travel path, and a carriage mounted for travel along the travel path and having a second vehicle-support surface. The first and second vehicle-support surfaces may be configured to support, in combination, a toy vehicle.

Abstract: A toy vehicle play set may include a toy vehicle and a track assembly including a track along which the vehicle may travel. In some examples the vehicle may include a drive mechanism that is adjustable for changing the speed of the vehicle, and a play set may include a speed changer for selectively changing the vehicle speed. In some examples, the track assembly may include a selectively actuated trapdoor in the track. In some examples, the play set may include a vehicle trap assembly having a cover defining a chamber for receiving, for example, a vehicle passing through the trapdoor opening. In some examples, the vehicle trap may include an assembly, such as the vehicle trap that falls apart when contacted by a vehicle traveling along the track.

Abstract: The present disclosure is directed to a toy play set for use with a toy vehicle comprising a platform attached to a support structure. In some examples, the play set may include a base and a support structure pivotally attached to the base with the support structure adapted to pivot relative to the base. In other examples, the toy play set may include a platform pivotally attached to the support structure and adapted to rotate in a toy vehicle's direction of travel. In still other examples, the toy play set may include first and second elongate tracks and means for carrying a toy vehicle from the first elongate track to the second elongate track. One disclosed embodiment includes first and second elongate tracks, a base, a support structure pivotally attached to the base, a platform pivotally attached to the support structure wherein the platform and support structure pivot at perpendicular axes that are parallel to the ground, and a vehicle receiving apparatus attached to the second elongate track.