Patents by Inventor Eric Sorscher

Eric Sorscher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230293498
    Abstract: This disclosure relates to compounds that are cystic fibrosis transmembrane conductance regulator (CFTR) modulators and pharmaceutical compositions containing the same. In certain embodiments, this disclosure relates to methods of managing a CFTR related disease or condition or respiratory distress comprising administering an effective amount of a CFTR modulator disclosed herein to a subject in need thereof.
    Type: Application
    Filed: July 30, 2021
    Publication date: September 21, 2023
    Inventors: Eric Sorscher, Haian Fu, Huw Davies, Jeong Hong, Yuhong Du, Andras Rab, Candela Manfredi, Xun Yang, Zhi Ren
  • Publication number: 20230102924
    Abstract: This disclosure relates to methods of treating cancer or initiating, enhancing, or prolonging an anti-tumor response in a subject in need thereof comprising administering to the subject an effective amount of a checkpoint inhibitor in combination with a purine cleaving enzyme or a vector encoding expression thereof, and a prodrug cleaved by said purine cleaving enzyme. In certain embodiments, this disclosure relates to methods of treating cancer or initiating, enhancing, or prolonging an anti-tumor response in a subject in need thereof comprising administering to the subject an effective amount of a checkpoint inhibitor in combination with a purine cleaving enzyme, or a vector encoding expression thereof, in the absence of a prodrug cleaved by said purine cleaving enzyme.
    Type: Application
    Filed: March 10, 2021
    Publication date: March 30, 2023
    Inventors: Eric Sorscher, Jeong Hong, Turang Behbahani, Regina Rab, Annette Ehrhardt, Disha Joshi
  • Publication number: 20060233754
    Abstract: A process is provided for activating gene transfer in a cell by administering a gene transfer activating compound to the cell in conjunction with a gene transfer vector. A kit for activating gene transfer as well as process for identifying a compound that activates gene transfer are described. Use of a gene transfer activator compound enhances gene transfer of a given gene transfer vector.
    Type: Application
    Filed: July 2, 2003
    Publication date: October 19, 2006
    Applicant: UAB RESEARCH FOUNDATION
    Inventor: Eric Sorscher
  • Publication number: 20050214901
    Abstract: A host cell stably transformed or transfected by a vector including a DNA sequence encoding for mutant purine nucleoside cleavage enzymes is provided. The transformed or transfected host cell can be used in combination with a purine substrate to treat tumour cells and/or virally infected cells. A nucleotide sequence encoding mutant E. coli derived purine nucleoside phosphorylase proteins which can be used in conjunction with an appropriate substrate to produce toxins which impair abnormal cell growth is also provided. A method is detailed for the delivery of toxin by generation withing target cells or by administration and delivery to the cells from without. Novel purine nucleosides are detailed that yield a cytotoxic purine upn enzymatic cleavage. A synthetic process for nucleosides is also detailed.
    Type: Application
    Filed: October 28, 2002
    Publication date: September 29, 2005
    Inventors: Steven Ealick, William Parker, John Secrist III, Eric Sorscher