Abstract: A handheld, therapeutic cleansing system includes a cleansing implement, for example a brush or pumice stone, magnetically coupled to a cleansing device. The cleansing device may include an elongated handle and a head portion extending from an end of the handle. The cleansing device may include a plurality of nozzles positioned around a perimeter of the head portion. The cleansing device may define an annular fluid path in fluid communication with the plurality of nozzles to supply fluid to the nozzles. The cleansing device may include a first magnetic material positioned radially inward of the annular fluid path. The cleansing implement may be magnetically coupled to the head portion of the cleansing device. The cleansing implement may include a second magnetic material that is magnetically attracted to the first magnetic material to couple the cleansing implement to the head portion of the cleansing device.

Abstract: A handheld, therapeutic cleansing system includes a cleansing implement, for example a brush or pumice stone, magnetically coupled to a cleansing device. The cleansing device may include an elongated handle and a head portion extending from an end of the handle. The cleansing device may include a plurality of nozzles positioned around a perimeter of the head portion. The cleansing device may define an annular fluid path in fluid communication with the plurality of nozzles to supply fluid to the nozzles. The cleansing device may include a first magnetic material positioned radially inward of the annular fluid path. The cleansing implement may be magnetically coupled to the head portion of the cleansing device. The cleansing implement may include a second magnetic material that is magnetically attracted to the first magnetic material to couple the cleansing implement to the head portion of the cleansing device.

Abstract: A product, such as one or more thin sheets, each containing a single or near-single crystalline inclusion-containing magnetic microstructure, is provided. In one embodiment, the inclusion-containing magnetic microstructure is a Galfenol-carbide microstructure. Various methods and devices, as well as compositions, are also described.

Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Abstract: The invention relates to the therapeutic or prophylactic treatment of fungal infections. The invention provides new methods for therapeutically or prophylactically treating fungal infections using sub-lethal concentrations of an anti-invasin compound. The methods according to the invention have fewer toxicology problems than existing methods, and thus can be used prophylactically, as well as for early treatment for high risk patients without a firm diagnosis. The methods according to the invention can also be used to treat an established fungal infection. The invention further provides novel genes that regulate fungal hyphal growth.

Abstract: Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, Nc1, Vps34 and fungal homologs thereof.

Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

Abstract: The invention relates to the therapeutic or prophylactic treatment of fungal infections. The invention provides new methods for therapeutically or prophylactically treating fungal infections using sub-lethal concentrations of an anti-invasin compound. The methods according to the invention have fewer toxicology problems than existing methods, and thus can be used prophylactically, as well as for early treatment for high risk patients without a firm diagnosis. The methods according to the invention can also be used to treat an established fungal infection. The invention further provides novel genes that regulate fungal hyphal growth.

Abstract: The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.