Abstract: This disclosure relates to systems and methods for managing access to data through enforcement of one or more associated rules. In various embodiments, a directory may be used to manage and/or otherwise record various relationships between objects, that may include governed objects such as data sets, and associated rules and rule sets. Access requests involving governed objects may be compared with relevant rules to determine whether the requested access should be allowed and what, if any, restrictions should be applied in connection with such access. Various embodiments of the disclosed systems and methods may allow for a data governance model that is flexible, allows for use across multiple complex organizations, and is highly extensible.

Abstract: This disclosure relates to, among other things, secure data rights management and governance. Certain embodiments disclosed herein provide for a data access control and management architecture that enforces one or more rules, restrictions, and/or configurations in connection with managing access requests to data. In various embodiments, one or more of the enforced rules, restrictions, and/or configurations may articulate access conditions that depend, at least in part, on a source, physical location, and/or an execution environment associated with a data access request. In this manner, data access may be managed and/or governed based, at least in part, on the source, location, system and/or associated environment requesting access to the data.

Abstract: This disclosure relates to systems and methods for managing access to data through enforcement of one or more associated rules. In various embodiments, a directory may be used to manage and/or otherwise record various relationships between objects, that may include governed objects such as data sets, and associated rules and rule sets. Access requests involving governed objects may be compared with relevant rules to determine whether the requested access should be allowed and what, if any, restrictions should be applied in connection with such access. Various embodiments of the disclosed systems and methods may allow for a data governance model that is flexible, allows for use across multiple complex organizations, and is highly extensible.

Abstract: This disclosure relates to, among other things, systems and methods for managing and/or verifying the integrity and/or provenance of digital content and/or media. Embodiments of the systems and methods disclosed herein may provide a mechanism for generating a secure records relating to digital content and/or other media by capturing records relating to creation and/or modification actions performed in connection with digital content and/or media and storing such records in a ledger. Trusted services that examine captured information recorded in trusted databases and/or ledgers and generate derivative information relating to associated content and/or media. When viewing content, trusted content applications may query the trusted service for derivative information relating to the content and/or media, providing users with an indication of the derivative information in connection with content and/or media playback.

Abstract: The disclosure relates to, among other things, systems and methods for securely managing personal information, which may include vaccination and/or other health status information. Aspects of the disclosed embodiments may use trusted ledgers and/or ledger derivatives in connection with managing personal information. Various mechanisms are described which facilitate cooperation and trust between various certification authorities, which may comprise public health authorities, allowing for cross jurisdictional verification of certified personal information.

Abstract: This disclosure relates to, among other things, scalable data processing, storage, and/or management systems and methods. Certain embodiments disclosed herein provide for a data management architecture that allows for more secure storage of enterprise data, making it more secure, usable, and/or interoperable, facilitating data usage across information silos. Further embodiments provide for comprehensive data access authentication and/or authorization functionality between various services included in embodiments of the disclosed architecture.

Abstract: A compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1, Ca, Cb, Cd, and n are the same as described in the specification. Disclosed is a method of diagnosing or monitoring a patient suffering from cancer, the method comprising: administering a pharmaceutical composition comprising an effective amount of an active agent, wherein the active agent is the compound of Formula I, a pharmaceutically acceptable salt of any of the foregoing thereof, or a combination thereof, together with a pharmaceutically acceptable carrier to the patient and diagnosing or monitoring the patient by hyperpolarized 13C-MRI. Also disclosed is a method of synthesizing 1-13C-5-12C-diacid.

Abstract: A method of diagnosing or monitoring a patient suffering from cancer, the method comprising: administering a pharmaceutical composition comprising an effective amount of an active agent, wherein the active agent is [1-13C] N-acetyl cysteine, a deuterated derivative thereof, a pharmaceutically acceptable salt of any of the foregoing thereof, or a combination thereof, together with a pharmaceutically acceptable carrier to the patient; and diagnosing or monitoring the patient by hyperpolarized 13C-MRI. Also disclosed is a method of synthesizing [1-13C] N-acetyl cysteine or a deuterated derivative thereof.

Abstract: Disclosed herein are compounds having a structure according to Formula I and optionally Formula IV. The compounds may be radiolabeled compounds useful for diagnosis and/or imaging fungal infections. In such embodiments, at least one substituent is a radionuclide, such as 18F. Also disclosed are precursor compounds according to Formula I and/or IV that are useful for making the radiolabeled compounds. In such embodiments, the precursor compound comprises at least one leaving group suitable for introducing a radionuclide, such as 18F, at a desired position. Also disclosed are methods for making and using the compounds, including embodiments of a method for imaging and/or diagnosing a fungal infection in a subject.

Abstract: A rechargeable lead-acid battery is provided. The rechargeable lead-acid battery includes a casing, a grid structure and an electro-mechanical assembly. The casing defines an interior configured to accommodate plates and a supply of fluid that is electrically reactive with the plates to generate electricity. The grid structure is interposed between lower edges of the plates and a bottom of the casing. The electro-mechanical assembly is coupled with the grid structure and operable to agitate the grid structure.

Abstract: A rechargeable lead-acid battery is provided. The rechargeable lead-acid battery includes a casing, a grid structure and an electro-mechanical assembly. The casing defines an interior configured to accommodate plates and a supply of fluid that is electrically reactive with the plates to generate electricity. The grid structure is interposed between lower edges of the plates and a bottom of the casing. The electro-mechanical assembly is coupled with the grid structure and operable to agitate the grid structure.

Abstract: This disclosure relates to systems and methods for managing access to data through enforcement of one or more associated rules. In various embodiments, a directory may be used to manage and/or otherwise record various relationships between objects, that may include governed objects such as data sets, and associated rules and rule sets. Access requests involving governed objects may be compared with relevant rules to determine whether the requested access should be allowed and what, if any, restrictions should be applied in connection with such access. Various embodiments of the disclosed systems and methods may allow for a data governance model that is flexible, allows for use across multiple complex organizations, and is highly extensible.

Abstract: This disclosure relates to systems and methods for communicating and storing data that may include genomic data. In certain embodiments, a sample genome may be stored and/or communicated as a list of variants relative to a reference dataset. Transmission and/or storage of a set of variants relative to a reference genome may allow for more efficient storage and/or communication of the sample genome. Systems and methods are further disclosed that allow for the efficient selection and computation of a reference dataset used to represent a set of sample genomes.

Abstract: This disclosure relates to systems and methods for communicating and storing data that may include genomic data. In certain embodiments, a sample genome may be stored and/or communicated as a list of variants relative to a reference dataset. Transmission and/or storage of a set of variants relative to a reference genome may allow for more efficient storage and/or communication of the sample genome. Systems and methods are further disclosed that allow for the efficient selection and computation of a reference dataset used to represent a set of sample genomes.

Abstract: The present embodiments advantageously provide methods and systems for use in decrypting content, and in some preferred embodiments expanding a security environment to distribute the computational processing involved in decryption. In some embodiments, a method for use in decrypting content is provided that receives a first content key at a first system for the decryption of a first track of encrypted content; encrypts the first content key according to a first instance key known at the first system; communicates the first encrypted content key over an externally accessible communication link to a second system; generates the first instance key at the second system independent of the first system; decrypts the first encrypted content key using the generated first instance key at the second system; and decrypts the first track of encrypted content using the first unencrypted content key at the second system.

Abstract: As a result of the inability to assign security in multiple applications at one time, there is an opportunity to tie the disparate security systems together. Security synchronization services is a method and apparatus that uses roles to provide a common administration experience for all applications that use it and fits better for new applications.

Abstract: As a result of the inability to assign security in multiple applications at one time, there is an opportunity to tie the disparate security systems together. Security synchronization services is a method and apparatus that uses roles to provide a common administration experience for all applications that use it and fits better for new applications.

Abstract: A packet processing system architecture and method are provided. According to a first aspect of the invention, packet parser functions are distributed throughout a packet processing system comprising a packet classification system and a packet modification system. According to a second aspect of the invention, an egress mirroring function is provided to the system. According to a third aspect of the invention, a multi-dimensional quality of service indicator for a packet is provided. According to a fourth aspect of the invention, a cascaded combination of multiple, replicated packet processing systems is used to process a packet. A fifth aspect of the invention involves any combination of one or more of the foregoing.

Abstract: Systems and methods are disclosed for managing and protecting electronic content and applications. Applications, content, and/or users can be given credentials by one or more credentialing authorities upon satisfaction of a set of requirements. Rights management software/hardware is used to attach and detect these credentials, and to enforce rules that indicate how content and applications may be used if certain credentials are present or absent. In one embodiment an application may condition access to a piece of electronic content upon the content's possession of a credential from a first entity, while the content may condition access upon the application's possession of a credential from a second entity and/or the user's possession of a credential from a third entity. Use of credentials in this manner enables a wide variety of relatively complex and flexible control arrangements to be put in place and enforced with relatively simple rights management technology.

Abstract: A method for monitoring time so that the use of protected content can be controlled includes receiving a trusted time value from a trusted authority external to a client device. When the client is no longer in communication with the trusted authority, the previously-received trusted time value is updated by use of the client's operating system counter so that a calculated trusted time value is derived for content license evaluation purposes.