Patents by Inventor Eric T. Whalley

Eric T. Whalley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING CENTRAL NERVOUS SYSTEM ISCHEMIC OR HEMORRHAGIC INJURY USING ANTI ALPHA4 INTEGRIN ANTAGONISTS
    Publication number: 20140127195
    Abstract: Methods of, and compositions for, treating central nervous system injury with an antagonist of an alpha4 subunit containing integrin are described.
    Type: Application
    Filed: January 10, 2014
    Publication date: May 8, 2014
    Applicant: BIOGEN IDEC MA INC.
    Inventors: Jane K. Relton, Roy R. Lobb, Eric T. Whalley, Steve P. Adams
  • Bradykinin antagonist
    Patent number: 6075120
    Abstract: A bradykinin antagonist of the formula:(BKAn)(X)(Y)where BKAn is a bradykinin antagonist peptide; Y is a pharmacore; and X is a bridging link chemically joining the BKAn and Y components.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: June 13, 2000
    Assignee: Cortech, Inc.
    Inventors: John C. Cheronis, James K. Blodgett, Val Smith Goodfellow, Manoj Vinayak Marathe, Lyle W. Spruce, Eric T. Whalley
  • Bradykinin antagonists
    Patent number: 5863899
    Abstract: A bradykinin antagonist of the formula:(BKAn) (X) (Y)where BKAn is a bradykinin antagonist peptide; Y is a Pharmacophore; and X is a bridging link chemically joining the BKAn and Y components.
    Type: Grant
    Filed: August 29, 1994
    Date of Patent: January 26, 1999
    Assignee: Cortech, Inc.
    Inventors: John C. Cheronis, James K. Blodgett, Val Smith Goodfellow, Manoj Vinayak Marathe, Lyle W. Spruce, Eric T. Whalley
  • Cytolytic bradykinin antagonists
    Patent number: 5849863
    Abstract: The present invention provides bradykinin antagonists effective to inhibit cancer cell growth. Also provided are methods of inhibiting lung cancer cell growth by administering a therapeutically effective amount of a dimerized bradykinin antagonist.
    Type: Grant
    Filed: September 8, 1995
    Date of Patent: December 15, 1998
    Assignees: University of Colorado, Cortech, Inc.
    Inventors: John M. Stewart, Daniel C. Chan, Eric T. Whalley, Lajos Gera
  • Bradykinin antagonists
    Patent number: 5843900
    Abstract: The present invention relates to pharmaceutically effective heterodimers comprising a bradykinin antagonist component covalently linked to a mu-opioid agonist component.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 1, 1998
    Assignee: Cortech, Inc.
    Inventors: John C. Cheronis, Albert Gyorkos, Lyle W. Spruce, Eric T. Whalley
  • Des-Arg.sup.9 -BK antagonists
    Patent number: 5834431
    Abstract: The present invention provides des-Arg.sup.9 bradykinin analogs which are selective B1 receptor antagonists.
    Type: Grant
    Filed: September 8, 1995
    Date of Patent: November 10, 1998
    Assignees: Cortech, Inc., University of Colorado
    Inventors: John M. Stewart, Eric T. Whalley, Lajos Gera
  • Bradykinin antagonists with extended hydrophobic side chains
    Patent number: 5750506
    Abstract: Bradykinin antagonists, particularly Cys.sup.6 analogs, which have an extended hydrophobic side chain.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: May 12, 1998
    Assignee: Cortech, Inc.
    Inventors: Val S. Goodfellow, Heather B. Kroona, Eric T. Whalley, Francine E. Wincott, Dana A. Zummach
  • Bradykinin antagonist peptides incorporating N-substituted glycines
    Patent number: 5700779
    Abstract: The present invention provides bradykinin type peptides containing N-substituted glycines, particularly bradykinin antagonist peptides useful for the treatment of conditions mediated by bradykinin including pain and inflammation.
    Type: Grant
    Filed: June 20, 1996
    Date of Patent: December 23, 1997
    Assignee: Cortech, Inc.
    Inventors: Val S. Goodfellow, Manoj V. Marathe, Eric T. Whalley, Timothy D. Fitzpatrick, Karen G. Kuhlman
  • Bradykinin antagonist peptides containing indane-substituted amino acids
    Patent number: 5648336
    Abstract: The present invention pertains to modified bradykinin antagonist peptides of the formula X-A.sup.0 -B.sup.1 -C.sup.2 -D.sup.3 -E.sup.4 -F.sup.5 -G.sup.6 -H.sup.7 -J.sup.8 -K.sup.9, where at least one of F.sup.5, H.sup.7 and J.sup.8 is an indane substituted amino acids.
    Type: Grant
    Filed: November 18, 1994
    Date of Patent: July 15, 1997
    Assignee: University of Colorado
    Inventors: John M. Stewart, Lajos Gera, Eric T. Whalley
  • Bradykinin antagonists
    Patent number: 5635593
    Abstract: A brandykinin antagonist of the formula:X(BKA).sub.nwherein BKA is the peptide chain of a bradykinin antagonist peptide, X is a linking group and n is a whole number greater than 1. The BKA substituents may be the same or different. Monomeric antagonists of the formula X(BKA) are also disclosed. Also disclosed are bradykinin antagonists of the formula:(Y)(X)(BKA)where X and BKA have the meanings indicated above and Y is the peptide chain of an antagonist or agonist for a non-bradykinin receptor.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: June 3, 1997
    Assignee: Cortech, Inc.
    Inventors: John C. Cheronis, James K. Blodgett, Eric T. Whalley, Shadrach R. Eubanks, Lisa G. Allen, Khe T. Nguyen
  • Bradykinin antagonists
    Patent number: 5620958
    Abstract: A bradykinin antagonist of the formula:X(BKA).sub.nwherein BKA is the peptide chain of a bradykinin antagonist peptide, X is a linking group and n is a whole number greater than 1. The BKA substituents may be the same or different. Monomeric antagonists of the formula X(BKA) are also disclosed. Also disclosed are bradykinin antagonists of the formula:(Y)(X)(BKA)where X and BKA have the meanings indicated above and Y is the peptide chain of an antagonist or agonist for a non-bradykinin receptor.
    Type: Grant
    Filed: April 13, 1994
    Date of Patent: April 15, 1997
    Assignee: Coretech, Inc.
    Inventors: John C. Cheronis, James K. Blodgett, Eric T. Whalley, Shadrach R. Eubanks, Lisa G. Allen, Khe T. Nguyen
  • Bradykinin receptor antagonists with neurokinin receptor blocking activity
    Patent number: 5610140
    Abstract: The present invention provides a heterodimeric compound possessing bradykinin and neurokinin receptor antagonist activities useful in the treatment of asthma and other inflammatory diseases especially those involving the airway or pulmonary system. The present invention is also useful in the treatment of pain and inflammation.
    Type: Grant
    Filed: August 1, 1994
    Date of Patent: March 11, 1997
    Assignee: Cortech, Inc.
    Inventors: Val S. Goodfellow, Eric T. Whalley, Francine E. Wincott
  • Bradykinin antagonists
    Patent number: 5416191
    Abstract: A bradykinin antagonist of the formulaX(BKA).sub.nwherein BKA is the peptide chain of a bradykinin antagonist peptide, X is a linking group and n is a whole number greater than 1. The BKA substituents may be the same or different. Monomeric antagonists of the formula X(BKA) are also disclosed.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: May 16, 1995
    Assignee: Cortech, Inc.
    Inventors: John C. Cheronis, Eric T. Whalley, Khe T. Nguyen, Shadrach R. Eubanks, Lisa G. Allen