Abstract: The present specification relates to AZD9833 for use in the treatment of cancer and methods of treatment of cancer involving administration of AZD9833 wherein, in each case, the AZD9833 is administered orally once daily at a dose between 25 mg and 450 mg. AZD9833 may be administered alone or its use may be in combination with an additional anti-cancer agent such as a CDK inhibitor, everolimus or an AKT inhibitor.

Abstract: The technology provides a spectroscopy system having a fringe tilted grating that varies a refractive index to diffract light. The diffracting mechanism may be formed by modulating a refractive index to produce fringe planes that are oriented relative to each other through a depth of the grating material The spectroscopy system includes a detector that converts optical signals into electrical signals to render spectral data. The spectroscopy system employs the fringe tilted grating to minimize fictitious Raman peaks that correspond to a fluorescence response signature.

Abstract: The invention provides stable coronavirus spike proteins. Immunogenic compositions comprising same and the methods of using these immunogenic compositions are also provided.

Abstract: A fiber optic probe is provided with a distal sampling end, a proximal end, and light delivery and collection paths therethrough. The probe includes a window disposed at the distal sampling end of the fiber optic probe, the window having a distal end and a proximal end, the window having a light blocking material that reduces a surface area that receives light rays. A lens is disposed near the proximal end of the window, the lens having a distal end, a proximal end, and an aperture. A light delivery optical fiber is provided having a distal end and a proximal end, the light rays being directed through the aperture. A collection optical fiber is provided in optical communication with the lens and the window. The probe may include a lens collection filter disposed between the window and the lens.

Abstract: In various examples, object detections of a machine learning model are leveraged to automatically generate new ground truth data for images captured at different perspectives. The machine learning model may generate a prediction of a detected object at the different perspective, and an object tracking algorithm may be used to track the object through other images in a sequence of images where the machine learning model may not have detected the object. New ground truth data may be generated as a result of the object tracking algorithms outputs, and the new ground truth data may be used to retrain or update the machine learning model, train a different machine learning model, or increase the robustness of a ground truth data set that may be used for training machine learning models from various perspectives.

Abstract: A feedback apparatus and method for dynamically controlling e-commerce platforms comprising a central engine is configured to connect with an e-commerce platform associated with a plurality of communication devices and a plurality of engagement engines and fulfillment engines that interact with the communication devices; the central engine is configured to dynamically add, remove or adjust the computational resources in the e-commerce platform in order to achieve a target efficiency for engagements with the communication devices and fulfillments from the communication devices. A graphical interface for controlling the feedback apparatus is also provided.

Abstract: In various examples, object detections of a machine learning model are leveraged to automatically generate new ground truth data for images captured at different perspectives. The machine learning model may generate a prediction of a detected object at the different perspective, and an object tracking algorithm may be used to track the object through other images in a sequence of images where the machine learning model may not have detected the object. New ground truth data may be generated as a result of the object tracking algorithms outputs, and the new ground truth data may be used to retrain or update the machine learning model, train a different machine learning model, or increase the robustness of a ground truth data set that may be used for training machine learning models from various perspectives.

Abstract: A feedback apparatus and method for dynamically controlling e-commerce platforms comprising a central engine is configured to connect with an e-commerce platform associated with a plurality of communication devices and a plurality of engagement engines and fulfillment engines that interact with the communication devices; the central engine is configured to dynamically add, remove or adjust the computational resources in the e-commerce platform in order to achieve a target efficiency for engagements with the communication devices and fulfillments from the communication devices. A graphical interface for controlling the feedback apparatus is also provided.

Abstract: In various examples, object detections of a machine learning model are leveraged to automatically generate new ground truth data for images captured at different perspectives. The machine learning model may generate a prediction of a detected object at the different perspective, and an object tracking algorithm may be used to track the object through other images in a sequence of images where the machine learning model may not have detected the object. New ground truth data may be generated as a result of the object tracking algorithms outputs, and the new ground truth data may be used to retrain or update the machine learning model, train a different machine learning model, or increase the robustness of a ground truth data set that may be used for training machine learning models from various perspectives.

Abstract: A fiber optic probe is provided with a distal sampling end, a proximal end, and light delivery and collection paths therethrough. The probe includes a window disposed at the distal sampling end of the fiber optic probe, the window having a distal end and a proximal end. A lens is disposed at the proximal end of the window, the lens having a distal end, a proximal end, and an aperture. A light delivery optical fiber is provided having a distal end and a proximal end, the distal end being received by the lens aperture. An optical isolator provided within the lens aperture to optically isolate the light delivery path and the light collection path. A collection optical fiber is provided in optical communication with the fiber collection filter. The probe may include a lens collection filter disposed between the window and the lens.

Abstract: In various examples, object detections of a machine learning model are leveraged to automatically generate new ground truth data for images captured at different perspectives. The machine learning model may generate a prediction of a detected object at the different perspective, and an object tracking algorithm may be used to track the object through other images in a sequence of images where the machine learning model may not have detected the object. New ground truth data may be generated as a result of the object tracking algorithms outputs, and the new ground truth data may be used to retrain or update the machine learning model, train a different machine learning model, or increase the robustness of a ground truth data set that may be used for training machine learning models from various perspectives.

Abstract: The present specification relates to AZD9833 for use in the treatment of cancer and methods of treatment of cancer involving administration of AZD9833 wherein, in each case, the AZD9833 is administered orally once daily at a dose between 25 mg and 450 mg. AZD9833 may be administered alone or its use may be in combination with an additional anti-cancer agent such as a CDK inhibitor, everolimus or an AKT inhibitor.

Abstract: The technology provides a spectroscopy system having a fringe tilted grating that varies a refractive index to diffract light. The diffracting mechanism may be formed by modulating a refractive index to produce fringe planes that are oriented relative to each other through a depth of the grating material The spectroscopy system includes a detector that converts optical signals into electrical signals to render spectral data. The spectroscopy system employs the fringe tilted grating to minimize fictitious Raman peaks that correspond to a fluorescence response signature.

Abstract: According to an embodiment of the present invention is an sighting device based on camera comprising a camera module and a display module, wherein the camera module comprises main body, photographing unit mounted on the main body to photograph a target, flip cover for opening and closing the open side of the main body, infrared light emitting device installed in a predetermined area of the open side, laser light emitting device installed in a predetermined area of the open side and a first short-range communication module for short-range wireless communication, wherein the display module comprises screen for reproducing the image captured by the camera module in real time or near real time, manipulation unit for manipulating the image reproduced on the screen and a second short-range communication module communicated with the camera module.

Abstract: A fiber optic probe is provided with a distal sampling end, a proximal end, and light delivery and collection paths therethrough. The probe includes a window disposed at the distal sampling end of the fiber optic probe, the window having a distal end and a proximal end. A lens is disposed near the proximal end of the window, the lens having a distal end, a proximal end, and an aperture. A light delivery optical fiber is provided having a distal end and a proximal end, the light rays being directed through the aperture. A collection optical fiber is provided in optical communication with the lens and the window. The probe may include a lens collection filter disposed between the window and the lens and an optical isolator provided within the aperture to optically isolate the light delivery path and the light collection path.

Abstract: A fiber optic probe is provided with a distal sampling end, a proximal end, and light delivery and collection paths therethrough. The probe includes a window disposed at the distal sampling end of the fiber optic probe, the window having a distal end and a proximal end. A lens is disposed near the proximal end of the window, the lens having a distal end, a proximal end, and an aperture. A light delivery optical fiber is provided having a distal end and a proximal end, the light rays being directed through the aperture. A collection optical fiber is provided in optical communication with the lens and the window. The probe may include a lens collection filter disposed between the window and the lens and an optical isolator provided within the aperture to optically isolate the light delivery path and the light collection path.

Abstract: In various examples, object detections of a machine learning model are leveraged to automatically generate new ground truth data for images captured at different perspectives. The machine learning model may generate a prediction of a detected object at the different perspective, and an object tracking algorithm may be used to track the object through other images in a sequence of images where the machine learning model may not have detected the object. New ground truth data may be generated as a result of the object tracking algorithms outputs, and the new ground truth data may be used to retrain or update the machine learning model, train a different machine learning model, or increase the robustness of a ground truth data set that may be used for training machine learning models from various perspectives.

Abstract: Described herein are devices and methods for pumping fluids. The devices may be implanted within a patient or located external to the body of the patient. When employed externally, the devices may be used to deliver various drugs or support hemodialysis, in addition to pumping blood and maintaining blood circulation. The implantable devices may be used in patients in need of circulatory assistance or a replacement heart. Both the implantable and external pump devices may linearly reciprocate a shuttle within a housing to simultaneously move blood into and out of the housing, and rotate the shuttle to selectively direct the movement of fluid into and out of a plurality of ports in the housing.

Abstract: The technology provides a spectroscopy system having two or more spectrometers with substantially uniform focal lengths. The spectrometers include a detector that converts optical signals into electrical signals to render spectral data. The spectroscopy system includes a computing device that is electrically coupled to one or more detectors to receive the spectral data and compare the spectral data against other spectral data. The other spectral data originates from spectrometers that have substantially similar focal lengths, slit widths, excitation laser wavelengths, or any combination of these. The technology includes an application server that is communicatively coupled to a second spectroscopy system. The application server includes software that enables data sharing among the two or more spectroscopy systems, including sharing the spectral data and the other spectral data. The application server compares sampled spectral data against stored spectral data to identify a match.

Abstract: The invention provides stable coronavirus spike proteins. Immunogenic compositions comprising same and the methods of using these immunogenic compositions are also provided.