Patents by Inventor Eric V. Shusta

Eric V. Shusta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN BLOOD-BRAIN BARRIER TARGETING ANTIBODIES
    Publication number: 20260062480
    Abstract: The present invention provides antibodies or antigen-binding fragments thereof including single chain variable fragment (scFv) antibodies that specifically bind to and translocate the blood-brain barrier and methods of use.
    Type: Application
    Filed: November 10, 2025
    Publication date: March 5, 2026
    Inventors: Eric V. SHUSTA, Charles C. STUTZ, Loukas GOULATIS, Julia GEORGIEVA
  • Human blood-brain barrier targeting antibodies
    Patent number: 12492251
    Abstract: The present invention provides antibodies or antigen-binding fragments thereof including single chain variable fragment (scFv) antibodies that specifically bind to and translocate the blood-brain barrier and methods of use.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: December 9, 2025
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Eric V. Shusta, Charles C. Stutz, Loukas Goulatis, Julia Georgieva
  • Variable lymphocyte receptors that target the blood brain barrier and methods of use
    Patent number: 12371468
    Abstract: The present disclosure provides isolated polypeptides comprising variable lymphocyte receptors that specifically bind the blood brain barrier, compositions, and methods of use.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: July 29, 2025
    Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION, EMORY UNIVERSITY
    Inventors: Eric V. Shusta, Jason M. Lajoie, Brantley R. Herrin
  • VARIABLE LYMPHOCYTE RECEPTORS THAT TARGET THE BRAIN EXTRACELLULAR MATRIX AND METHODS OF USE
    Publication number: 20250059234
    Abstract: The present disclosure provides isolated polypeptides comprising variable lymphocyte receptors that specifically bind the brain extracellular matrix, compositions, and methods of use. Methods of using the variable lymphocyte receptors for the detection and treatment of disease or injury, specifically, for example, cancers including glioblastoma are provided.
    Type: Application
    Filed: July 26, 2024
    Publication date: February 20, 2025
    Inventors: Eric V. SHUSTA, Benjamin UMLAUF, Brantley HERRIN, Paul CLARK, John Shu-Shin KUO
  • METHOD OF DIFFERENTIATING HUMAN PLURIPOTENT STEM CELLS TO PODOCYTES
    Publication number: 20240409903
    Abstract: The present invention provides methods and kits for differentiating podocytes from pluripotent stem cells and from other cell types.
    Type: Application
    Filed: May 21, 2024
    Publication date: December 12, 2024
    Inventors: Tongcheng Qian, Sean P. Palecek, Eric V. Shusta
  • Blood brain barrier (BBB)-selective antibodies and methods of use thereof to target agents to the BBB
    Patent number: 12161889
    Abstract: The present invention provides antibodies or antigen binding fragments thereof including single chain variable fragment (scFv) antibodies that specifically bind to the blood brain barrier in vivo and methods of use.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: December 10, 2024
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Eric V. Shusta, Charles C. Stutz
  • Variable lymphocyte receptors that target the brain extracellular matrix and methods of use
    Patent number: 12077609
    Abstract: The present disclosure provides isolated polypeptides comprising variable lymphocyte receptors that specifically bind the brain extracellular matrix, compositions, and methods of use. Methods of using the variable lymphocyte receptors for the detection and treatment of disease or injury, specifically, for example, cancers including glioblastoma are provided.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: September 3, 2024
    Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION, EMORY UNIVERSITY
    Inventors: Eric V. Shusta, Benjamin Umlauf, Brantley Herrin, Paul Clark, John Kuo
  • Method of differentiating human pluripotent stem cells to podocytes
    Patent number: 12024721
    Abstract: The present invention provides methods and kits for differentiating podocytes from pluripotent stem cells and from other cell types.
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: July 2, 2024
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Tongcheng Qian, Sean P. Palecek, Eric V. Shusta
  • ANTIBODIES TARGETING GLIOBLASTOMA STEM-LIKE CELLS AND METHODS OF USE THEREOF
    Publication number: 20240018263
    Abstract: The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
    Type: Application
    Filed: September 7, 2023
    Publication date: January 18, 2024
    Inventors: Michael Zorniak, Paul A. Clark, Yongku Peter Cho, Benjamin J. Umlauf, Eric V. Shusta, John Shu-Shin Kuo
  • Isogenic blood-brain barrier model
    Patent number: 11840708
    Abstract: A method of creating an isogenic multicellular blood-brain barrier model from iPSCs is disclosed.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: December 12, 2023
    Assignees: WISCONSIN ALUMNI RESEARCH FOUNDATION, CEDARS-SINAI MEDICAL CENTER
    Inventors: Eric V. Shusta, Scott G. Canfield, Clive N. Svendsen, Sean P. Palecek, Gad D. Vatine
  • METHOD OF CREATING HUMAN PLURIPOTENT STEM CELL DERIVED BRAIN PERICYTE-LIKE CELLS
    Publication number: 20230383246
    Abstract: A population of brain pericyte-like cells, wherein the cells express pericyte markers but do not express ACTA2 and wherein the cells are generated from hPSCs, is disclosed herein.
    Type: Application
    Filed: April 18, 2023
    Publication date: November 30, 2023
    Inventors: Eric V. Shusta, Sean P. Palecek, Matthew Stebbins
  • HUMAN BLOOD-BRAIN BARRIER MODEL FOR IMMUNOLOGICAL STUDIES
    Publication number: 20230375530
    Abstract: The present invention provides methods for differentiating brain microvascular endothelial cells having barrier properties and a mature immune phenotype for use in making an in vitro blood-brain barrier (BBB) model. Further, a BBB model having barrier properties and a mature immune phenotype is provided.
    Type: Application
    Filed: September 28, 2021
    Publication date: November 23, 2023
    Inventors: Eric V. SHUSTA, Hideaki NISHIHARA, Benjamin GASTFRIEND, Sean P. PALECEK, Britta ENGELHARDT
  • HUMAN BLOOD-BRAIN BARRIER TARGETING ANTIBODIES
    Publication number: 20230331835
    Abstract: The present invention provides antibodies or antigen-binding fragments thereof including single chain variable fragment (scFv) antibodies that specifically bind to and translocate the blood-brain barrier and methods of use.
    Type: Application
    Filed: January 28, 2021
    Publication date: October 19, 2023
    Inventors: Eric V. SHUSTA, Charles C. STUTZ, Loukas GOULATIS, Julia GEORGIEVA
  • Antibodies targeting glioblastoma stem-like cells and methods of use thereof
    Patent number: 11780932
    Abstract: The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: October 10, 2023
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Michael Zorniak, Paul A. Clark, Yongku Peter Cho, Benjamin J. Umlauf, Eric V. Shusta, John Shu-Shin Kuo
  • Method of creating human pluripotent stem cell derived brain pericyte-like cells
    Patent number: 11643636
    Abstract: A population of brain pericyte-like cells, wherein the cells express pericyte markers but do not express ACTA2 and wherein the cells are generated from hPSCs, is disclosed herein.
    Type: Grant
    Filed: July 10, 2019
    Date of Patent: May 9, 2023
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Eric V. Shusta, Sean P. Palecek, Matthew Stebbins
  • VARIABLE LYMPHOCYTE RECEPTORS THAT TARGET THE BLOOD BRAIN BARRIER AND METHODS OF USE
    Publication number: 20220204583
    Abstract: The present disclosure provides isolated polypeptides comprising variable lymphocyte receptors that specifically bind the blood brain barrier, compositions, and methods of use.
    Type: Application
    Filed: February 11, 2020
    Publication date: June 30, 2022
    Inventors: Eric V. Shusta, Jason M. Lajoie, Brantley R. Herrin
  • VARIABLE LYMPHOCYTE RECEPTORS THAT TARGET THE BRAIN EXTRACELLULAR MATRIX AND METHODS OF USE
    Publication number: 20220041659
    Abstract: The present disclosure provides isolated polypeptides comprising variable lymphocyte receptors that specifically bind the brain extracellular matrix, compositions, and methods of use. Methods of using the variable lymphocyte receptors for the detection and treatment of disease or injury, specifically, for example, cancers including glioblastoma are provided.
    Type: Application
    Filed: December 19, 2019
    Publication date: February 10, 2022
    Inventors: Eric V. SHUSTA, Benjamin UMLAUF, Brantley HERRIN, Paul CLARK, John KUO
  • BLOOD BRAIN BARRIER SELECTIVE ANTIBODIES AND METHODS OF USE
    Publication number: 20210277108
    Abstract: The present invention provides antibodies or antigen binding fragments thereof including single chain variable fragment (scFv) antibodies that specifically bind to the blood brain barrier in vivo and methods of use.
    Type: Application
    Filed: July 24, 2019
    Publication date: September 9, 2021
    Inventors: Eric V. SHUSTA, Charles C. STUTZ
  • ANTIBODIES TARGETING GLIOBLASTOMA STEM-LIKE CELLS AND METHODS OF USE THEREOF
    Publication number: 20200354472
    Abstract: The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
    Type: Application
    Filed: October 9, 2018
    Publication date: November 12, 2020
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Michael Zorniak, Paul A. Clark, Yongku Peter Cho, Benjamin J. Umlauf, Eric V. Shusta, John Shu-Shin Kuo
  • Retinoic acid enhanced human stem cell derived blood brain barrier model
    Patent number: 10590393
    Abstract: In one embodiment, the present invention is a method of creating a fully-human blood-brain barrier (BBB) model, comprising the steps of (a) obtaining a mixture of neural cells and brain microvascular endothelial cells (BMECs), wherein the neural cells and BMECs that comprise the mixture were produced from the differentiation of human pluripotent stem cells (hPSCs); (b) purifying BMECs from the mixture of neural cells and BMECs of step (a); and (c) co-culturing the purified BMECs with a cell type selected from the group consisting of pericytes, astrocytes and differentiated neural progenitor cells (NPCs), wherein a blood brain barrier model is created.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: March 17, 2020
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Eric V. Shusta, Sean P. Palecek, Ethan S. Lippmann, Samira M. Azarin