Patents by Inventor Eric Valéry
Eric Valéry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12214297Abstract: The invention relates to a method for separating a mixture in an installation comprising a first system comprising a plurality of chromatography columns, a second system downstream of the first system and a tank fed by an outlet line of the first system and feeding the second system with a continuous stream, the method successively comprising, in a cyclical manner, in a given part of the first system, steps of collecting a raffinate, injecting the mixture to be separated, collecting an extract and injecting a mobile phase; wherein the method further comprises the measurement of the purity and/or yield of at least one collected fraction, comprising: the determination of the concentration of at least two species of the mixture to be separated in the fraction collected in the tank; and the determination of the purity and/or yield of at least one species of the fraction collected in the tank.Type: GrantFiled: November 14, 2023Date of Patent: February 4, 2025Assignee: Novasep Process SolutionsInventors: Cédric Prieur, Eric Valéry
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Patent number: 11987853Abstract: The invention relates to a method for purifying a mixture to be separated, in a multicolumn chromatography system, the method comprising successively and cyclically: a step of collecting a raffinate, a step of injecting the mixture to be separated, a step of collecting an extract and an eluent injection step, at an operating temperature; wherein the mixture to be separated has a viscosity at 20° C. greater than or equal to 3 mPa·s; and wherein the dry matter mass concentration of the mixture to be separated is equal, within 5%, to a threshold concentration, said threshold concentration is such that: the viscosity of the mixture to be treated at a dry matter mass concentration equal to the threshold concentration and at the operating temperature, is equal to twice the viscosity of the mixture to be treated, at a dry matter mass concentration equal to 85% of the threshold concentration and at the operating temperature.Type: GrantFiled: April 22, 2019Date of Patent: May 21, 2024Assignee: NOVASEP PROCESS SOLUTIONSInventors: Eric Valery, Cédric Prieur
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Publication number: 20240082752Abstract: The invention relates to a method for separating a mixture in an installation comprising a first system comprising a plurality of chromatography columns, a second system downstream of the first system and a tank fed by an outlet line of the first system and feeding the second system with a continuous stream, the method successively comprising, in a cyclical manner, in a given part of the first system, steps of collecting a raffinate, injecting the mixture to be separated, collecting an extract and injecting a mobile phase; wherein the method further comprises the measurement of the purity and/or yield of at least one collected fraction, comprising: the determination of the concentration of at least two species of the mixture to be separated in the fraction collected in the tank; and the determination of the purity and/or yield of at least one species of the fraction collected in the tank.Type: ApplicationFiled: November 14, 2023Publication date: March 14, 2024Inventors: Cédric Prieur, Eric Valéry
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Publication number: 20240075405Abstract: The invention relates to a method for separating a mixture in a system comprising a plurality of chromatography columns, the method successively comprising, in a cyclical manner, in a given part of the system, steps of collecting a raffinate, injecting the mixture to be separated, collecting an extract and injecting a mobile phase; wherein the method further comprises measuring the purity and/or yield of a collected fraction, comprising: the determination, in a node of the system, of the histories of at least two variables that are representative of the concentration of at least two species contained in the mixture to be separated using at least one fast online detector; the determination of the concentration of at least two species of the mixture to be separated in the collected fraction based on these histories; and the determination of the purity and/or yield of the collected fraction based on these concentrations.Type: ApplicationFiled: November 14, 2023Publication date: March 7, 2024Inventors: Cédric Prieur, Eric Valéry
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Patent number: 11857892Abstract: The invention relates to a method for separating a mixture in a system comprising a plurality of chromatography columns, the method successively comprising, in a cyclical manner, in a given part of the system: a step of collecting a raffinate; a step of injecting the mixture to be separated; a step of collecting an extract; and a step of injecting a mobile phase; the method further comprising: determining, in a node of the system, the history of a variable representing the concentration of at least one species contained in the mixture to be separated; detecting, within said history, a characteristic point between the beginning of a step of collecting the extract and the end of the following step of collecting the raffinate; comparing the position of the characteristic point in relation to a target position; and adjusting the carrier volume of the characteristic point, modifying the position of the characteristic point in order to bring the position of the characteristic point closer to the target position; thType: GrantFiled: November 16, 2018Date of Patent: January 2, 2024Assignee: NOVASEP PROCESS SOLUTIONSInventors: Cedric Prieur, Eric Valery
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Publication number: 20220119443Abstract: The invention relates to an apparatus for purification of biomolecules, comprising an injection device comprising an injection channel provided with at least one inlet for a precipitation agent composition and a plurality of outlets on the external surface of the injection channel and a mixing device comprising a mixing channel with at least one main inlet for a composition to be purified and at least one main outlet, and a plurality of secondary inlets, wherein the injection device and the mixing device are coupled such that each of the plurality of outlets of the injection device is connected to a respective secondary inlet of the mixing channel. The invention further relates to a set comprising the apparatus, a composition comprising at least one biomolecule and at least one impurity, and a composition comprising at least one precipitation agent, and to a method for purification of biomolecules using the apparatus.Type: ApplicationFiled: September 28, 2021Publication date: April 21, 2022Inventors: Eric Valery, Maria Del Carme Pons-Royo
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Publication number: 20210164007Abstract: The invention relates to a method for producing a fructose composition comprising the following successive stages: provision of an initial composition comprising glucose; concentration of the initial composition by evaporation of water to obtain a concentrated initial composition; isomerization of glucose to fructose from the concentrated initial composition, making it possible to obtain an intermediate composition; purification of the intermediate composition in a multicolumn chromatography system, making it possible to obtain a glucose-rich raffinate and a fructose-rich extract; concentration of the extract by evaporation of water; wherein the intermediate composition is not subjected to a concentration step by evaporation of water between the isomerization step and the purification step.Type: ApplicationFiled: April 22, 2019Publication date: June 3, 2021Inventors: Damien Brichant, Eric Valery
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Publication number: 20210032711Abstract: The invention relates to a method for purifying a mixture to be separated, in a multicolumn chromatography system, the method comprising successively and cyclically: a step of collecting a raffinate, a step of injecting the mixture to be separated, a step of collecting an extract and an eluent injection step, at an operating temperature; wherein the mixture to be separated has a viscosity at 20° C. greater than or equal to 3 mPa·s; and wherein the dry matter mass concentration of the mixture to be separated is equal, within 5%, to a threshold concentration, said threshold concentration is such that: the viscosity of the mixture to be treated at a dry matter mass concentration equal to the threshold concentration and at the operating temperature, is equal to twice the viscosity of the mixture to be treated, at a dry matter mass concentration equal to 85% of the threshold concentration and at the operating temperature.Type: ApplicationFiled: April 22, 2019Publication date: February 4, 2021Inventors: Eric Valery, Cédric Prieur
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Publication number: 20210023474Abstract: The invention relates to a method for separating a mixture in a system comprising a plurality of chromatography columns, the method successively comprising, in a cyclical manner, in a given part of the system: a step of collecting a raffinate; a step of injecting the mixture to be separated; a step of collecting an extract; and a step of injecting a mobile phase; the method further comprising: determining, in a node of the system, the history of a variable representing the concentration of at least one species contained in the mixture to be separated; detecting, within said history, a characteristic point between the beginning of a step of collecting the extract and the end of the following step of collecting the raffinate; comparing the position of the characteristic point in relation to a target position; and adjusting the carrier volume of the characteristic point, modifying the position of the characteristic point in order to bring the position of the characteristic point closer to the target position; thType: ApplicationFiled: November 16, 2018Publication date: January 28, 2021Inventors: Cedric Prieur, Eric Valery
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Patent number: 10870895Abstract: The invention relates to a method for purifying a solution, the method comprising the following successive steps: —bringing a solution to be purified into contact with an ion exchange resin by suspending the ion exchange resin in the solution to be purified, the ion exchange resin having the form of particles having a size Dv50 smaller than or equal to 200 ?m; —separating the solution into a purified solution and a loaded resin; —regenerating the loaded resin by passing at least one regenerating solution through a compact bed of loaded resin. The invention also relates to an assembly for implementing the method.Type: GrantFiled: November 22, 2017Date of Patent: December 22, 2020Assignee: Novasep ProcessInventors: Eric Valery, Cedric Prieur
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Patent number: 10751643Abstract: The invention relates to a fluid distributor (9, 10) for a column (1) comprising at least one cell (2) containing a bed of particles (3), the fluid distributor (9, 10) comprising: —a floor (11, 21) comprising at least one injection point (15, 25) providing a fluidic connection on either side thereof; —a layer of a resistive medium (12, 22) fixed on one face of the floor (11, 21), the resistive medium being permeable to the fluid; —a spacing device (13, 23) inserted between the floor (11, 21) and the layer of resistive medium (12, 22) and maintaining a space for the circulation of the fluid between the floor (11, 21) and the layer of resistive medium (12, 22). The invention also relates to a column, in particular a chromatography column, provided with this fluid distributor.Type: GrantFiled: May 13, 2015Date of Patent: August 25, 2020Assignee: NOVASEP PROCESSInventors: Eric Valery, Cédric Prieur, Nicolas Pautal, Stéphane Oliveira
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Publication number: 20190300973Abstract: The invention relates to a method for purifying a solution, the method comprising the following successive steps: —bringing a solution to be purified into contact with an ion exchange resin by suspending the ion exchange resin in the solution to be purified, the ion exchange resin having the form of particles having a size Dv50 smaller than or equal to 200 ?m; —separating the solution into a purified solution and a loaded resin; —regenerating the loaded resin by passing at least one regenerating solution through a compact bed of loaded resin. The invention also relates to an assembly for implementing the method.Type: ApplicationFiled: November 22, 2017Publication date: October 3, 2019Inventors: Eric Valery, Cedric Prieur
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Publication number: 20180036652Abstract: The invention relates to a fluid distributor (9,10)for a column (1)comprising at least one cell (2) containing a bed of particles (3), the fluid distributor (9, 10) comprising: - a floor (11, 21) comprising at least one injection point (15, 25) providing a fluidic connection on either side thereof; - a layer of resistive medium (12, 22) fixed on one face of the floor(11, 21), the resistive medium being permeable to the fluid; - a spacing device (13, 23) inserted between the floor (11, 21) and the layer of reistive medium (12, 22) and maintaining a space for the circulation of the fluid between the floor (11, 21) and the layer of resistive medium (12, 22). The invention also relates to a column, in particular a chromatography column, provided with this fluid distributor.Type: ApplicationFiled: May 13, 2015Publication date: February 8, 2018Applicant: NOVASEP PROCESSInventors: Eric Valery, Cédric Prieur, Nicolas Pautal, Stéphane Oliveira
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Patent number: 9802881Abstract: The invention relates to a method for purifying a first fatty acid, in particular a first polyunsaturated fatty acid, using an initial mixture further comprising at least one second fatty acid and a third fatty acid, with the method comprising at least: a first step of chromatographic separation in liquid phase, using the initial mixture, making it possible to recover on the one hand a first flow enriched with a first fatty acid and on the other hand a flow enriched with a second fatty acid; a second step of chromatographic separation in liquid phase, using the first flow enriched with a first fatty acid, making it possible to recover on the one hand a second flow enriched with a first fatty acid and on the other hand a flow enriched with a third fatty acid, with the second step of chromatographic separation being carried out in a static bed chromatographic separation unit.Type: GrantFiled: December 9, 2014Date of Patent: October 31, 2017Assignee: NOVASEP PROCESSInventors: Eric Valéry, Jean Bléhaut
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Patent number: 9802882Abstract: The invention related to a method for purifying a first fatty acid, preferably polyunsaturated, using an initial mixture further comprising at least one second fatty acid, optionally a third fatty acid and optionally a fourth fatty acid, with the method comprising: a first step of chromatographic separation in liquid phase, using the initial mixture, carried out in a first unit for chromatographic separation, making it possible to recover on the one hand a first flow enriched with a first fatty acid and on the other hand a flow enriched with a second fatty acid, optionally, a second step of chromatographic separation in liquid phase, using the first flow enriched with a first fatty acid, carried out in a second chromatographic separation unit, making it possible to recover on the one hand a second flow enriched with a first fatty acid and on the other hand a flow enriched with a third fatty acid; optionally, a third step of chromatographic separation in liquid phase, using the third flow enriched with a fiType: GrantFiled: December 9, 2014Date of Patent: October 31, 2017Assignee: NOVASEP PROCESSInventors: Eric Valéry, Jean Bléhaut
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Publication number: 20170173495Abstract: A read circuit for an electrical signal produced by a POSFET device is disclosed which comprises a transconductance amplifier (4) connected at its inverting input to the output of the POSFET device (1), at least one neuron (8a, 8b) connected to the output of said transconductance amplifier, said amplifier being adapted to receive a signal from the POSFET device representative of a force or pressure exerted on it and to produce at its output at least one current signal (I0?, I0+) representative of such force or pressure, the at least one neuron being adapted to receive said current signal and to produce an output signal (12a, 12b) being a pulse train with frequency proportional to said current signal.Type: ApplicationFiled: May 13, 2015Publication date: June 22, 2017Applicant: NOVASEP PROCESSInventors: Eric Valery, Cédric Prieur, Nicolas Pautal, Stéphane Oliveira
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Publication number: 20160311750Abstract: The invention related to a method for purifying a first fatty acid, preferably polyunsaturated, using an initial mixture further comprising at least one second fatty acid, optionally a third fatty acid and optionally a fourth fatty acid, with the method comprising: a first step of chromatographic separation in liquid phase, using the initial mixture, carried out in a first unit for chromatographic separation, making it possible to recover on the one hand a first flow enriched with a first fatty acid and on the other hand a flow enriched with a second fatty acid, optionally, a second step of chromatographic separation in liquid phase, using the first flow enriched with a first fatty acid, carried out in a second chromatographic separation unit, making it possible to recover on the one hand a second flow enriched with a first fatty acid and on the other hand a flow enriched with a third fatty acid; optionally, a third step of chromatographic separation in liquid phase, using the third flow enriched with a fiType: ApplicationFiled: December 9, 2014Publication date: October 27, 2016Applicant: NOVASEP PROCESSInventors: Eric VALÉRY, Jean BLÉHAUT
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Publication number: 20160304433Abstract: The invention relates to a method for purifying a first fatty acid, in particular a first polyunsaturated fatty acid, using an initial mixture further comprising at least one second fatty acid and a third fatty acid, with the method comprising at least: a first step of chromatographic separation in liquid phase, using the initial mixture, making it possible to recover on the one hand a first flow enriched with a first fatty acid and on the other hand a flow enriched with a second fatty acid; a second step of chromatographic separation in liquid phase, using the first flow enriched with a first fatty acid, making it possible to recover on the one hand a second flow enriched with a first fatty acid and on the other hand a flow enriched with a third fatty acid, with the second step of chromatographic separation being carried out in a static bed chromatographic separation unit.Type: ApplicationFiled: December 9, 2014Publication date: October 20, 2016Applicant: NOVASEP PROCESSInventors: Eric VALÉRY, Jean BLÉHAUT
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Patent number: 9428711Abstract: A process is provided for recovering a first polyunsaturated fatty acid (PUFA) from a feed mixture including at least one additional fatty acid (e.g., a second fatty acid (FA)). The process optionally comprises: performing a main step of chromatographic separation using an aqueous organic eluent and collecting a first stream of eluent enriched in the first PUFA and a second stream of eluent enriched in the second FA; subjecting the second stream of eluent to a partial concentration step to obtain a concentrated portion including the second FA, and a depleted portion comprising eluent, but depleted of the second FA. The process also includes: at least partially recycling the depleted portion for use in the main step of chromatographic separation.Type: GrantFiled: January 7, 2014Date of Patent: August 30, 2016Assignee: Groupe NovasepInventors: Philippe Adam, Eric Valéry, Jean Bléhaut
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Patent number: 9180387Abstract: The invention concerns a method for separating fractions of a mixture to be separated, in a device (1) comprising: several chromatography columns (21, 22, 23,) mounted in series; an open separation loop comprising in input a point for injecting (6) eluent in one of the columns and in output a point for drawing (8) a fraction of the mixture. The method includes the following steps: batch injection of the mixture to be separated in the open separation loop (4); collecting at least two fractions; offsetting at least one column of the eluent injecting and fraction drawing points (6, 8) of the separation loop (4). The invention also concerns a device for separating fractions of a mixture to be separated.Type: GrantFiled: July 25, 2006Date of Patent: November 10, 2015Assignee: NOVASEP PROCESSInventors: Eric Valery, Olivier Ludemann-Hombourger