Patents by Inventor Eric VAN BELLE

Eric VAN BELLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of retinoic acid receptor (RAR) agonists for reversing, preventing, or delaying calcification of aortic valve
    Patent number: 12589189
    Abstract: Aortic valve calcification is a condition in which calcium deposits form on the aortic valve in the heart. These deposits can cause narrowing at the opening of the aortic valve. This narrowing can become severe enough to reduce blood flow through the aortic valve—a condition called aortic valve stenosis. The inventors have shown that retinoic acid decreases calcification and osteoblast-like phenotype in valvular interstitial cells (VICs). More particularly, RAR? activation reduces calcification and osteoblast-like phenotype in VIC. On the contrary, ALDH1A1 inhibition increases calcification and osteoblast-like phenotype in VIC. Thus the results prompt to consider that use or retinoic acid receptor (RAR) agonists would be suitable for the reversing, preventing or delaying calcification of the aortic valve.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: March 31, 2026
    Assignees: INSERM (INSTITUTE NATIONAL DE LA SANTA ET DE LA RECHERCHE MEDICALE), Université de Lille, Instiut Pasteur de Lille, Centre Hospitalier Régional Universitaire de Lille
    Inventors: Sophie Susen, Delphine Corseaux, Yoann Sottejeau, Mickael Rosa, Jérôme Soquet, Eric Van Belle, Bart Staels, Annabelle Dupont
  • Novel Use of Von Willebrand Factor
    Publication number: 20200038489
    Abstract: The present invention relates to a von Willebrand factor composition for the prevention and/or the treatment of haemorrhage and/or bleeding in patients with mechanical circulatory support.
    Type: Application
    Filed: October 10, 2019
    Publication date: February 6, 2020
    Applicants: Laboratoire Francais du Fractionnement et des Biotechnologies, Ctre Hospitalier Universitaire de Lille, Universite Lille 2 Droit et Sante
    Inventors: Sophie SUSEN, Andre VINCENTELLI, Eric VAN BELLE, Antoine RAUCH, Flavien VINCENT
  • Use of von Willebrand factor
    Patent number: 10478475
    Abstract: The present invention relates to a von Willebrand factor composition for the prevention and/or the treatment of haemorrhage and/or bleeding in patients with mechanical circulatory support.
    Type: Grant
    Filed: April 6, 2016
    Date of Patent: November 19, 2019
    Assignees: LABORATOIRE FRANCAIS DU FRACTIONNEMENT ET DES BIOTECHNOLOGIES, CTRE HOSPITALIER UNIVERSITAIRE DE LILLE, UNIVERSITE LILLE 2 DROIT ET SANTE
    Inventors: Sophie Susen, Andre Vincentelli, Eric Van Belle, Antoine Rauch, Flavien Vincent
  • NOVEL USE OF VON WILLEBRAND FACTOR
    Publication number: 20180110838
    Abstract: The present invention relates to a von Willebrand factor composition for the prevention and/or the treatment of haemorrhage and/or bleeding in patients with mechanical circulatory support.
    Type: Application
    Filed: April 6, 2016
    Publication date: April 26, 2018
    Applicants: Laboratoire Francais du Fractionnement des Biotechnologies, CTRE Hospitalier Universitaire de Lille, Universite Lille 2 Droit et Sante
    Inventors: Sophie SUSEN, Andre VINCENTELLI, Eric VAN BELLE, Antoine RAUCH, Flavien VINCENT