Patents by Inventor Eric Vanderploeg
Eric Vanderploeg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11529438Abstract: Medical devices, substrates and biologic therapies for bone repair and guided tissue regeneration are disclosed. More particularly, bone graft substitutes and bone void fillers which comprise a porous collagen matrix and calcium deficient hydroxyapatite ceramic granules for delivery of osteoinductive or other therapeutic agents are disclosed.Type: GrantFiled: June 19, 2019Date of Patent: December 20, 2022Assignee: BIOVENTUS, LLCInventors: Christopher Wilson, Eric Vanderploeg, Cheryl Lee, Chase Davis, Howard Seeherman, John Wozney
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Patent number: 11452760Abstract: Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.Type: GrantFiled: October 4, 2018Date of Patent: September 27, 2022Assignee: BIOVENTUS, LLCInventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris
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Patent number: 11377352Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH), the granules comprising interconnected pores with a minimum mean diameter of 3 microns, to a first incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; (b) subjecting the granules to a second incubation in an alkaline aqueous solution having a pH-value of more than 10 and optionally PO43? ions; (c) filtering and drying the obtained porous granules of calcium deficient hydroxyapatite; and wherein (d) the sum of the amounts of PO43? ions present in the first and second incubation is at least as large as the amount of SO42? ions of the granules used for step (a).Type: GrantFiled: October 16, 2018Date of Patent: July 5, 2022Assignees: Bioventus, LLC, Mathys AG BettlachInventors: Alex De Gasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
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Patent number: 10807869Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of PO43? ions present in the incubation of step a) is at least as large as the amount of SO42? ions of the granules used for step (a).Type: GrantFiled: October 4, 2018Date of Patent: October 20, 2020Assignees: Mathys AG Bettlach, Bioventus, LLCInventors: Alex De Gasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
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Patent number: 10646347Abstract: Osteoconductive synthetic bone grafts are provided in which porous metallic matrices are loaded with an osteoinductive protein. In certain embodiments, the grafts include porous ceramic granules deposited within the matrices.Type: GrantFiled: June 12, 2017Date of Patent: May 12, 2020Assignee: Bioventus LLC.Inventors: Jeffrey Welch, Eric Vanderploeg, Christopher Wilson, John Wozney
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Publication number: 20190388585Abstract: Medical devices, substrates and biologic therapies for bone repair and guided tissue regeneration are disclosed. More particularly, bone graft substitutes and bone void fillers which comprise a porous collagen matrix and calcium deficient hydroxyapatite ceramic granules for delivery of osteoinductive or other therapeutic agents are disclosed.Type: ApplicationFiled: June 19, 2019Publication date: December 26, 2019Inventors: Christopher WILSON, Eric VANDERPLOEG, Cheryl LEE, Chase DAVIS, Howard SEEHERMAN, John WOZNEY
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Patent number: 10300172Abstract: Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.Type: GrantFiled: October 31, 2016Date of Patent: May 28, 2019Assignee: Bioventus, LLC.Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher Todd Brown
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Publication number: 20190070256Abstract: Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.Type: ApplicationFiled: October 4, 2018Publication date: March 7, 2019Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris
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Publication number: 20190047862Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH), the granules comprising interconnected pores with a minimum mean diameter of 3 microns, to a first incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; (b) subjecting the granules to a second incubation in an alkaline aqueous solution having a pH-value of more than 10 and optionally PO43? ions; (c) filtering and drying the obtained porous granules of calcium deficient hydroxyapatite; and wherein (d) the sum of the amounts of PO43? ions present in the first and second incubation is at least as large as the amount of SO42? ions of the granules used for step (a).Type: ApplicationFiled: October 16, 2018Publication date: February 14, 2019Inventors: Alex De Gasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
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Publication number: 20190031511Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of P43? ions present in the incubation of step a) is at least as large as the amount of SO42? ions of the granules used for step (a).Type: ApplicationFiled: October 4, 2018Publication date: January 31, 2019Inventors: Alex De Gasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
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Patent number: 10150672Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of PO43? ions present in the incubation of step a) is at least as large as the amount of SO42? ions of the granules used for step (a).Type: GrantFiled: June 22, 2015Date of Patent: December 11, 2018Assignee: Bioventus, LLC.Inventors: Alex DeGasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
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Patent number: 10130678Abstract: Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.Type: GrantFiled: December 29, 2015Date of Patent: November 20, 2018Assignee: Bioventus, LLC.Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris
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Patent number: 10131543Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH), the granules comprising interconnected pores with a minimum mean diameter of 3 microns, to a first incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; (b) subjecting the granules to a second incubation in an alkaline aqueous solution having a pH-value of more than 10 and optionally PO43? ions; (c) filtering and drying the obtained porous granules of calcium deficient hydroxyapatite; and wherein (d) the sum of the amounts of PO43? ions present in the first and second incubation is at least as large as the amount of SO42? ions of the granules used for step (a).Type: GrantFiled: June 23, 2014Date of Patent: November 20, 2018Assignees: Bioventus, LLC., Mathys AG BettlachInventors: Alex DeGasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
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Publication number: 20170354504Abstract: Osteoconductive synthetic bone grafts are provided in which porous metallic matrices are loaded with an osteoinductive protein. In certain embodiments, the grafts include porous ceramic granules deposited within the matrices.Type: ApplicationFiled: June 12, 2017Publication date: December 14, 2017Inventors: Jeffrey WELCH, Eric Vanderploeg, Christopher Wilson, John Wozney
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Publication number: 20170319750Abstract: Osteoconductive synthetic bone grafts are provided in which porous ceramic granules are embedded in a biocompatible matrix material. The grafts, which may also include one or more of a coating, a reinforcing bio-absorbable mesh, and an osteoinductive protein or peptide, are generally porous and may incorporate fenestrations.Type: ApplicationFiled: May 8, 2017Publication date: November 9, 2017Inventors: Orly Grinberg, Nadav Orr, Howard Seeherman, Oded Shoseyov, Eric Vanderploeg, Christopher Wilson, John Wozney
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Publication number: 20170209623Abstract: Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.Type: ApplicationFiled: October 31, 2016Publication date: July 27, 2017Inventors: Eric Vanderploeg, Howard Seeherman, Christopher G. Wilson, John Wozney, Christopher Todd Brown
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Publication number: 20170197833Abstract: The method is for producing porous calcium deficient hydroxyapatite granules and comprises the following steps: (a) subjecting granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) to an incubation in an alkaline aqueous solution having a pH-value of less than 10 and containing PO43? ions; whereby the granules of calcium sulfate anhydrous (CSA), calcium sulfate dihydrate (CSD) or calcium sulfate hemihydrate (CSH) comprise interconnected pores with a minimum mean diameter of 3 microns; (b) washing with water the granules obtained after incubation of step a); (c) drying the obtained porous granules of calcium deficient hydroxyapatite; whereby (d) the amount-of PO43? ions present in the incubation of step a) is at least as large as the amount of SO42? ions of the granules used for step (a).Type: ApplicationFiled: June 22, 2015Publication date: July 13, 2017Inventors: Alex De Gasparo, Noemie Van Garderen, Marc Bohner, Howard Seeherman, Eric Vanderploeg
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Publication number: 20160184390Abstract: Systems and methods for preparing synthetic osteoinductive bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.Type: ApplicationFiled: December 29, 2015Publication date: June 30, 2016Inventors: Eric Vanderploeg, Howard Seeherman, Christopher C. Wilson, John Wozney, Christopher T. Brown, John A. Kambouris