Abstract: Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.

Abstract: In a vehicular seat assembly, a side impact resistant seat cushion includes a base plate. A foam pad and a fabric covering are disposed over the base plate. Laterally extending first and second beams are fixed to the base plate for rigidifying the base plate to increase resistance to buckling under side impact loading thereby improving passenger safety. The first and second beam are rigidly held in a parallel relationship above the top surface of the base plate by right and left brackets. In the case of a full length style bench seat, a bridge bracket may be provided to span and support intermediate gapped sections in each of the first and second beams. The first and second beams provide an added measure of column strength to the base plate during side impact situations where prior art base plates would have a tendency to buckle and fold.