Patents by Inventor Eric Vieira

Eric Vieira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Naphthyridin derivatives
    Patent number: 7511055
    Abstract: The present invention relates to heterocyclic derivatives of formula I wherein R1, R2 and R3 are as defined in the description and claims, which compounds are metabotropic glutamate receptor 5 antagonists.
    Type: Grant
    Filed: September 28, 2006
    Date of Patent: March 31, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Jaeschke, Sabine Kolczewski, Richard Hugh Philip Porter, Patrick Schnider, Eric Vieira
  • METHODS FOR THE TREATMENT OF GERD WITH MGLUR5 ANTAGONISTS
    Publication number: 20090054490
    Abstract: The present invention relates to methods for the treatment, prevention and/or delay of progression of gastro-esophageal reflux disease (GERD) by administering compounds that act as antagonists of metabotropic glutamate type-5 receptors (mGluR5 receptor antagonists), for example compounds of formula (I) wherein A, E, R1, R2, R2 and R4 are as defined in the specification.
    Type: Application
    Filed: August 13, 2008
    Publication date: February 26, 2009
    Inventors: Georg Jaeschke, Sabine Kolczewski, Will Spooren, Eric Vieira
  • IMIDAZOLE DERIVATIVES
    Publication number: 20090018171
    Abstract: The present invention relates to imidazole derivatives of formula I wherein R1, R2, R3, R4, X, Y and R are described hereinabove, or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the imidazole derivatives of formula I, a process for preparing a compound of formula I, and a method of treating or preventing acute and/or chronic neurological disorder comprising administering to a patient in need of such treatment and/or prevention a therapeutically effective amount of said pharmaceutical composition. These disorders include Alzheimer's disease. These disorders also include mild cognitive impairment.
    Type: Application
    Filed: September 17, 2008
    Publication date: January 15, 2009
    Inventors: Bernd Buettelmann, Simona Maria Ceccarelli, Georg Jaeschke, Sabine Kolczewski, Richard Hugh Philip Porter, Eric Vieira
  • Imidazole derivatives
    Patent number: 7452909
    Abstract: The present invention relates to imidazole derivatives of formula I wherein R1, R2, R3, R4, X, Y and R are described hereinabove, or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the imidazole derivatives of formula I, a process for preparing a compound of formula I, and a method of treating or preventing acute and/or chronic neurological disorder comprising administering to a patient in need of such treatment and/or prevention a therapeutically effective amount of said pharmaceutical composition. These disorders include Alzheimer's disease. These disorders also include mild cognitive impairment.
    Type: Grant
    Filed: August 26, 2004
    Date of Patent: November 18, 2008
    Assignee: Hoffman-La Roche Inc.
    Inventors: Bernd Buettelmann, Simona Maria Ceccarelli, Georg Jaeschke, Sabine Kolczewski, Richard Hugh Philip Porter, Eric Vieira
  • PYRIDINE-2-CARBOXYAMIDE DERIVATIVES
    Publication number: 20080269256
    Abstract: The invention relates to compounds of formula I: wherein R1 to R3 are as defined in the specification, to processes for their preparation, to pharmaceutical compositions containing them, and to methods for treating CNS disorders.
    Type: Application
    Filed: July 1, 2008
    Publication date: October 30, 2008
    Inventors: Georg Jaeschke, Sabine Kolczewski, Richard Hugh Philip Porter, Eric Vieira
  • Pyridine-2-carboxyamide derivatives
    Patent number: 7414060
    Abstract: The invention relates to compounds of formula I: wherein R1 to R3 are as defined in the specification, to processes for their preparation, to pharmaceutical compositions containing them, and to methods for treating CNS disorders.
    Type: Grant
    Filed: February 23, 2006
    Date of Patent: August 19, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Georg Jaeschke, Sabine Kolczewski, Richard Hugh Philip Porter, Eric Vieira
  • IMIDAZOLE DERIVATIVES
    Publication number: 20080119489
    Abstract: The present invention relates to imidazole derivatives of formula I wherein R1, R2, R3 and R4 are described hereinabove. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognititve disorders and memory deficits, as well as chronic and acute pain.
    Type: Application
    Filed: October 31, 2007
    Publication date: May 22, 2008
    Inventors: Bernd Buettelmann, Simona Maria Ceccarelli, George Jaeschke, Sabine Kolczewski, Richard Hugh Philip Porter, Eric Vieira
  • IMIDAZOLE DERIVATIVES
    Publication number: 20080103306
    Abstract: The present invention relates to process for the preparation of an imidazole derivative of formula I, wherein R1, R2, R3 and R4 are described hereinabove. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognitive disorders and memory deficits, as well as chronic and acute pain.
    Type: Application
    Filed: December 13, 2007
    Publication date: May 1, 2008
    Inventors: Bernd Buettelmann, Simona Ceccarelli, Georg Jaeschke, Sabine Kolczewski, Richard Porter, Eric Vieira
  • Imidazole derivatives
    Patent number: 7332510
    Abstract: The present invention relates to imidazole derivatives of formula I wherein R1, R2, R3 and R4 are described hereinbelow. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer' disease, cognitive disorders and memory deficits, as well as chronic and acute pain.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: February 19, 2008
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Buettelmann, Simona Maria Ceccarelli, Georg Jaeschke, Sabine Kolczewski, Richard Hugh Philip Porter, Eric Vieira
  • 4-Aryl-pyridine-2-carboxyamide derivatives
    Publication number: 20070197553
    Abstract: The present invention relates to novel pyridine-2-carboxyamide derivatives of formula (I) useful as metabotropic glutamate receptor antagonists: wherein Y, Z, R1, R2 and R3 are as defined in the specification herein.
    Type: Application
    Filed: January 30, 2007
    Publication date: August 23, 2007
    Inventors: Georg Jaeschke, Will Spooren, Eric Vieira
  • Heteroaryl-substituted imidazole derivatives
    Patent number: 7241760
    Abstract: The present invention relates to imidazole derivatives of the general formula wherein R1, R2, R3 and R4 are described hereinbelow. These compounds can be used in the treatment or prevention of mGluR5 receptor mediated disorders. These compounds are useful, interalia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficits, as well as chronic and acute pain.
    Type: Grant
    Filed: June 12, 2004
    Date of Patent: July 10, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Buettelmann, Simona Maria Ceccarelli, Georg Jaeschke, Sabine Kolczewski, Richard Hugh Philip Porter, Eric Vieira
  • Thiazole[4,5-C]pyridine derivatives
    Publication number: 20070105891
    Abstract: The invention relates to compounds of general formula I: wherein R1, R2 and R3 are as defined in the description such compounds are metabotropic glutamate receptor antagonists and are useful in the treatment or prevention of mGluR5 receptor mediated disorders.
    Type: Application
    Filed: October 31, 2006
    Publication date: May 10, 2007
    Inventors: Georg Jaeschke, Sabine Kolczewski, Richard Porter, Patrick Schnider, Eric Vieira
  • Naphthyridin derivatives
    Publication number: 20070078155
    Abstract: The present invention relates to heterocyclic derivatives of formula I wherein R1, R2 and R3 are as defined in the description and claims, which compounds are metabotropic glutamate receptor 5 antagonists.
    Type: Application
    Filed: September 28, 2006
    Publication date: April 5, 2007
    Inventors: Georg Jaeschke, Sabine Kolczewski, Richard Porter, Patrick Schnider, Eric Vieira
  • Imidazole derivatives
    Patent number: 7153874
    Abstract: The present invention provides 4-[1-Aryl-imidazol-4-ylethynyl]-2-alkyl-pyridine and 1-heteroaryl-imidazol-4-ylethynyl]-2-alkyl-pyridine derivatives and pharmaceutically acceptable salts thereof for the treatment or prevention of disorders mediated in full or in part by metabotropic glutamate receptor 5. These disorders include, e.g. acute, traumatic and chronic degenerative processes of the nervous system, such as Alzheimer's disease, senile dementia, Parkinson's disease, Huntington's chorea, amyotrophic lateral sclerosis and multiple sclerosis, psychiatric diseases, such as schizophrenia and anxiety, depression, pain and drug dependency.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: December 26, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Buettelmann, Simona Maria Ceccarelli, Georg Jaeschke, Sabine Kolczewski, Richard Hugh Philip Porter, Eric Vieira
  • Oxazoles as mGluR1 enhancers
    Patent number: 7119113
    Abstract: The invention relates to carboxamide derivatives as defined in the specification and claims, to a process for their preparation, to pharmaceutical compositions comprising them and to their use as mGluR1 enhancers in the treatment and prevention of neurological disorders and diseases, such as Alzheimer's disease and dementia.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: October 10, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Joerg Huwyler, Frederic Knoflach, Eric Vieira, Juergen Wichmann
  • Pyridine-2-carboxyamide derivatives
    Publication number: 20060199960
    Abstract: The invention relates to compounds of formula I: wherein R1 to R3 are as defined in the specification, to processes for their preparation, to pharmaceutical compositions containing them, and to methods for treating CNS disorders.
    Type: Application
    Filed: February 23, 2006
    Publication date: September 7, 2006
    Inventors: Georg Jaeschke, Sabine Kolczewski, Richard Porter, Eric Vieira
  • Pyrazine-2-carboxyamide derivatives
    Publication number: 20060199828
    Abstract: The present invention is concerned with novel pyrazine 2-carboxyamide derivatives of formula (I) wherein R1, R2 and R3 are as defined in the specification. These compounds are useful for the treatment of CNS disorders.
    Type: Application
    Filed: February 28, 2006
    Publication date: September 7, 2006
    Inventors: Georg Jaeschke, Sabine Kolczewski, Richard Porter, Eric Vieira
  • Imidazole derivatives
    Patent number: 7091222
    Abstract: The present invention relates to imidazole derivatives of the general formula wherein R1, R2, R3 and R4 are as defined hereinabove. This invention also relates to the compound's pharmaceutically acceptable salt and processes for the preparation thereof. These compounds can be used for the manufacture of pharmaceutical compositions for the treatment and prevention of mGluR5 receptor mediated disorders. These compounds are useful, inter alia, in the treatment or prevention of acute and/or chronic neurological disorders such as psychosis, epilepsy, schizophrenia, Alzheimer's disease, cognitive disorders and memory deficit disorders, as well as chronic and acute pain.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: August 15, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernd Buettelmann, Simona Maria Ceccarelli, Georg Jaeschke, Sabine Kolczewski, Richard Hugh Philip Porter, Eric Vieira
  • Thiazole-4-carboxyamide derivatives
    Publication number: 20060160857
    Abstract: The present invention is concerned with novel thiazole 4-carboxyamide derivatives of the general formula (I) and with methods for the preparation thereof, which compounds are useful as metabotropic glutamate receptor antagonists: wherein R1 to R4 are as defined in the specification.
    Type: Application
    Filed: January 10, 2006
    Publication date: July 20, 2006
    Inventors: Bernd Buettelmann, Simona Ceccarelli, Georg Jaeschke, Sabine Kolczewski, Richard Porter, Eric Vieira
  • Diazole derivatives
    Publication number: 20060030559
    Abstract: The present invention relates to diazole derivatives of the general formula wherein A, E, R1, R2 and R3 are as defined in application and pharmaceutical compositions containing them. The invention also relates to use of such compounds for the treatment of diseases mediated by the metabotropic glutamate receptors (mGluR), such as anxiety, chronic and acute pain, protection against liver damage, urinary incontinence, obesity, Fragile-X and autism, Alzheimer's disease, epilepsy, schizophrenia, ischemia, Huntington's chorea, amyotrophic lateral sclerosis (ALS), dementia caused by AIDs, and Parkinson's disease.
    Type: Application
    Filed: May 31, 2005
    Publication date: February 9, 2006
    Inventors: Bernd Buettelmann, Simona Ceccarelli, Georg Jaeschke, Sabine Kolczewski, Richard Porter, Eric Vieira