Abstract: The present invention relates to bifunctional compounds for targeted kinase degradation, methods for treating diseases or conditions mediated by aberrant kinase activity, and methods for identifying degradable kinases and optimal kinase:scaffold pairs.

Abstract: Systems and methods are disclosed for managing services on a network. In one exemplary embodiment, the method includes receiving topologically relevant network information concerning nodes, interfaces, connections and/or protocols; resolving conflicts in the received information; determining and storing a network topology from the received and resolved information; and inferring one or more services based on the stored topology.

Abstract: Systems and methods are disclosed for testing a processor having at least a first interface. In one embodiment, the method includes configuring, at the processor, a second interface, such that the configured second interface has one or more quality of service parameters representative of the first interface; sending one or more packets through the configured second interface, the one or more packets being representative of another packet received at the first interface; and determining, based on the one or more packets, one or more performance parameters corresponding to the first interface under test.

Abstract: Systems and methods are disclosed for testing a processor having at least a first interface. In one embodiment, the method includes configuring, at the processor, a second interface, such that the configured second interface has one or more quality of service parameters representative of the first interface; sending one or more packets through the configured second interface, the one or more packets being representative of another packet received at the first interface; and determining, based on the one or more packets, one or more performance parameters corresponding to the first interface under test.

Abstract: Systems and methods are disclosed for simulating network performance. In one exemplary embodiment, the method includes inferring one or more services on the network; collecting network information based on actual traffic on the network; determining a traffic generator, such that the traffic generator represents the actual traffic on the network from a perspective of at least one of the inferred services; and simulating performance of the network using the determined traffic generator and at least one of the inferred services.

Abstract: A method and system are configured to infer one or more virtual private network (VPN) services within a physical network. Topologically relevant network information is received for the physical network with regard to nodes, interfaces, connections, and protocols, and the existence of each virtual private network service is inferred based on the stored network topology information. Network objects are also inferred, including routed paths, label switched paths, Internet Protocol Security (IPSec) tunnels, and Layer Two Tunneling Protocol (L2TP) tunnels.

Abstract: Systems and methods are disclosed for managing services on a network. In one exemplary embodiment, the method includes receiving topologically relevant network information concerning nodes, interfaces, connections and/or protocols; resolving conflicts in the received information; determining and storing a network topology from the received and resolved information; and inferring one or more services based on the stored topology.

Abstract: Systems and methods are disclosed for managing services on a network. In one exemplary embodiment, the method includes receiving topologically relevant network information concerning nodes, interfaces, connections and/or protocols; resolving conflicts in the received information; determining and storing a network topology from the received and resolved information; and inferring one or more services based on the stored topology.

Abstract: A network management system includes a user interface, a virtual network and a device communication manager. The virtual network includes models which represent network entities and model relations which represent relations between network entities. Each model includes network data relating to a corresponding network entity and one or more inference handlers for processing the network data to provide user information. The system performs a fault isolation technique wherein the fault status of a network device is suppressed when it is determined that the device is not defective. User displays include hierarchical location views and topological views of the network configuration. Network devices are represented on the displays by multifunction icons which permit the user to select additional displays showing detailed information regarding different aspects of the corresponding network device.

Abstract: What is disclosed is an arrangement of field of label augmented, multi-protocol routing of data packets in a network utilizing fixed length labels that are negotiated between adjacent label routing routers in the network. Portions of each routing label may be assigned by both upstream and downstream routers in the network. Routing labels are used in lieu of conventional address headers to route data packets through said network; and by using routing labels the routers have more flexibility in routing data packets through said network and can use network links between routers that normally carry less traffic.

Abstract: An apparatus and method for determining the topology of a computer network including data-relay devices and node devices, based on a comparison of source adddresses heard by the various data relay-devices. A source address table is compiled for each port of each data-relay device, and for each select pair of ports the addresses in the source tables are compared to determined whether there is an intersection of heard devices. In order to account for directed transmissions which are not heard at every port, further comparison is made of all of the other ports of the device, eliminating the ports for which the intersection is the empty set. From the determined connections, a topology of the network is graphed showing direct and transitive connections. In cases where there is both a direct and transitive connection, the redundant direct connection is eliminated.

Abstract: A network management system includes a user interface, a virtual network and a device communication manager. The virtual network includes models which represent network entities and model relations which represent relations between network entities. Each model includes network data relating to a corresponding network entity and one or more inference handlers for processing the network data to provide user information. The system performs a fault isolation technique wherein the fault status of a network device is suppressed when it is determined that the device is not defective. User displays include hierarchical location views and topological views of the network configuration. Network devices are represented on the displays by multifunction icons which permit the user to select additional displays showing detailed information regarding different aspects of the corresponding network device.

Abstract: A network management system includes a user interface, a virtual network and a device communication manager. The virtual network includes models which represent network entities and model relations which represent relations between network entities. Each model includes network data relating to a corresponding network device and one or more inference handlers for processing the network data to provide user information. The system performs a fault isolation technique wherein the fault status of a network device is suppressed when it is determined that the device is not defective. User displays include hierarchical location views and topological views of the network configuration. Network devices are represented on the displays by multifunction icons which permit the user to select additional displays showing detailed information regarding different aspects of the corresponding network device.