Patents by Inventor Eric WETERINGS

Eric WETERINGS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE INHIBITORS OF KU70/80 AND USES THEREOF
    Publication number: 20220274991
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a pyrimido-pyrimidine-dione (or similar) strucure which function as inhibitors of the Ku70/80 protein and the non-homologous end joining (NHEJ) pathway, and their use as therapeutics for the treatment of cancer and other diseases (e.g., treating subjects having conditions involving an aberrant, overexpressed or upregulated Ku70/80 profile, or subjects having conditions which canbe ameliorated by diminishing Ku70/80-mediated DSB repair).
    Type: Application
    Filed: July 16, 2020
    Publication date: September 1, 2022
    Inventors: Eric Weterings, Daruka Mahadevan, Josef Vagner
  • NOVEL MRNA BASED PROGNOSTIC INDEX DERIVED FROM DIFFERENTIAL EXPRESSION ANALYSIS IMPROVES OVERALL SURVIVAL ESTIMATES IN GLIOBLASTOMA
    Publication number: 20210317537
    Abstract: The present invention relates to diagnostic assays useful in classification of patients for selection of cancer therapy, and relates to a method of using a select family member of the Wnt signaling pathway (WIF1), an important component of the insulin-like growth factor pathway (IGFBP3), and other signaling factors (e.g., NGFR, IBSP, and HISTLH3G and COL1A2) as prognostic markers and potential therapeutic targets for patients with Glioblastoma Multiforme (GBM). In particular, the present invention is a novel GBM Prognostic Index (GPI) that predicts overall survival (OS) in GBM patients treated with the current standard of care.
    Type: Application
    Filed: May 14, 2021
    Publication date: October 14, 2021
    Inventors: Eric Weterings, Baldassarre D. Stea, Daruka Mahadevan, Christopher Michael Morrison, Michael F. Hammer
  • Small molecule inhibitors of Ku70/80 and uses thereof
    Patent number: 10308656
    Abstract: Provided herein are methods for identifying and treating subjects having conditions involving aberrant Ku70/80 activity. In particular, the invention relates to small-molecules which function as inhibitors of Ku70/80 protein and the non-homologous end-joining (NHEJ) pathway, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: June 4, 2019
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Eric Weterings, Daruka Mahadevan, Josef Vagner
  • SMALL MOLECULE INHIBITORS OF KU70/80 AND USES THEREOF
    Publication number: 20180244678
    Abstract: Provided herein are methods for identifying and treating subjects having conditions involving aberrant Ku70/80 activity. In particular, the invention relates to small-molecules which function as inhibitors of Ku70/80 protein and the non-homologous end-joining (NHEJ) pathway, and their use as therapeutics for the treatment of cancer and other diseases.
    Type: Application
    Filed: August 16, 2016
    Publication date: August 30, 2018
    Inventors: Eric WETERINGS, Daruka MAHADEVAN, Josef VAGNER