Abstract: Methods and systems for monitoring an environment history of a component using an indicator array that includes energy exposure indicator pads direct-printed onto a surface of the component in a geometric pattern. Each of the plurality of energy exposure indicator pads in the geometric pattern may include a mechanochromic material, a first thermochromic indicator responsive within a first temperature range, a second thermochromic indicator responsive within a second temperature range, and a third thermochromic indicator responsive within a third temperature range, provided that the first, second, and third temperature ranges are distinct from one another.

Abstract: Methods and systems for monitoring an environment history of a component using an indicator array that includes energy exposure indicator pads direct-printed onto a surface of the component in a geometric pattern. Each of the plurality of energy exposure indicator pads in the geometric pattern may include a mechanochromic material, a first thermochromic indicator responsive within a first temperature range, a second thermochromic indicator responsive within a second temperature range, and a third thermochromic indicator responsive within a third temperature range, provided that the first, second, and third temperature ranges are distinct from one another.

Abstract: A temperature sensitive relief valve for a reservoir of a hot fluid including a cold fluid inlet in communication with a cold fluid outlet via a main cold fluid feed arrangement; a fluid mixing chamber having an outlet; a hot fluid inlet adapted for attachment to the reservoir of hot fluid and in communication with the fluid mixing chamber; a secondary cold fluid feed arrangement in communication with the fluid mixing chamber; and a valve arrangement responsive to the temperature of the hot fluid in the reservoir so that, when the temperature of the hot fluid is below a pre-determined value, the valve arrangement is in a first configuration which prevents hot fluid and cold fluid from entering the fluid mixing chamber and, when the temperature of the hot fluid exceeds the pre-determined value, the valve arrangement adopts a second configuration which allows hot fluid and cold fluid to enter the fluid mixing chamber, thereafter to flow out of the outlet of the fluid mixing chamber as a mixed fluid having a tem

Abstract: The present invention relates to an improved process for the preparation of substituted 2-(4-carbonylmethoxy-optionally 2,5-disubstituted-phenyl-acetaldehydes, in particular 2-(4-alkoxycarbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes and their use in the synthesis of optionally substituted 2-[4-[2-[[-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethyl]-optionally 2,5-disubstituted-phenoxy]acetic acid derivatives or the salts thereof, which may be used as pharmaceutically active substances.

Abstract: A mixing valve assembly (10) having a main housing (12) with a mixing chamber with hot (22) and cold (24) fluid inlets and an outlet (20) allowing hot and cold fluid to enter and exit the mixing chamber (14). The valve assembly also has a cold fluid bypass pipe to allow a proportion of cold fluid flowing into the valve housing to exit the housing via a cold fluid outlet (34) without entering the mixing chamber.

Abstract: The present invention relates to an improved process for the preparation of substituted 2-(4-carbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes, in particular 2-(4-alkoxycarbonylmethoxy-optionally 2,5-disubstituted-phenyl)-acetaldehydes and their use in the synthesis of optionally substituted 2-[4-[2-[[-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-amino]ethyl]-optionally 2,5-disubstituted-phenoxy]acetic acid derivatives or the salts thereof, which may be used as pharmaceutically active substances.

Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, R1 through R4, D, A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.

Abstract: The present application relates to a process for preparing the CGRP-antagonist 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine of formula by means of which this compound can be prepared in large amounts, in high yields and with high purity.

Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I): which is carried out using an intermediate of the formula (II): wherein W, R1 through R4, D, A and R12 are as defined herein. The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.

Abstract: The invention relates to a method for the preparation of compound of formula (1). The invention further relates to the previously unknown compounds of formulas (5 and 6) as intermediates in the production of benzodiazepines of formula (1).

Abstract: The invention relates to a method for the preparation of compound of formula (1). The invention further relates to the previously unknown compounds of formulas (5 and 6) as intermediates in the production of benzodiazepines of formula (1).

Abstract: The invention relates to a method for representing compounds of the general formula (1). The invention further relates to the hitherto unknown compounds of general formulas (5, 6 and 7) in the form of intermediate products and to the use of 4,4-dimethyl-3&bgr; hydroxypregna-8,14-diene-21-carboxylic acid esters of the general formula (1) for producing 4,4-dimethyl-5&agr;-cholesta-8,14,24-triene-3&bgr;-ol (2).