Abstract: Provided herein are methods for treatment of cystic fibrosis (CF), including for patients with class I CFTR mutations. The methods may involve administration of a recombinant adeno-associated virus (rAAV) that includes an AV.TL65 capsid protein and a polynucleotide that includes an F5 enhancer and a tg83 promoter operably linked to a CFTR?R minigene, or a pharmaceutical composition thereof.

Abstract: A computing device includes a first display-supporting frame rotatably coupled to a second display-supporting frame along a hinge axis via a hinge assembly comprising a central spine extending parallel to the hinge axis. A flexible display is supported by the first display-supporting frame and the second display-supporting frame. A spine cover plate extends over the central spine and is moveably coupled to the hinge assembly for translation relative to the central spine as the first display-supporting frame is rotated relative to the second display-supporting frame.

Abstract: Provided herein are methods of transducing a recombinant viral, e.g., retroviral, vector, improving the transgene expression from a recombinant viral vector, and reducing titers of neutralizing antibodies that bind a recombinant viral vector. In general, these methods include administering to a subject a recombinant viral vector and an effective amount of an immunosuppressive regimen.

Abstract: A laser level includes a level body, the level body including a body housing and a laser light source contained in the body housing, the laser light source configured to emit a laser light beam plane so as to project a laser light line on a target surface, the laser light beam plane configured to form an adjustable angle relative to a horizontal plane, and the laser level including a fixing structure configured to fix the laser light source such that the laser light beam plane projected therefrom is fixed at an adjusted angle, the laser light line providing a levelling height when in a horizontal state. The laser level further includes an adjustment means configured to adjust the attitude of the laser light source when the laser light line projected onto the target surface from the laser light source from a non-horizontal state to a horizontal state.

Abstract: A method includes monitoring a temperature of a memory component of a memory sub-system to determine that the temperature of the memory component corresponds to a first monitored temperature value; writing data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the first monitored temperature value; determining that the first monitored temperature value exceeds a threshold temperature range; monitoring the temperature of the memory component of the memory sub-system to determine that the temperature of the memory component corresponds to a second monitored temperature value that is within the threshold temperature range; and rewriting the data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the second monitored temperature value.

Abstract: A method includes monitoring a temperature of a memory component of a memory sub-system to determine that the temperature of the memory component corresponds to a first monitored temperature value; writing data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the first monitored temperature value; determining that the first monitored temperature value exceeds a threshold temperature range; monitoring the temperature of the memory component of the memory sub-system to determine that the temperature of the memory component corresponds to a second monitored temperature value that is within the threshold temperature range; and rewriting the data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the second monitored temperature value.

Abstract: A method includes monitoring a temperature of a memory component of a memory sub-system to determine that the temperature of the memory component corresponds to a first monitored temperature value; writing data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the first monitored temperature value; determining that the first monitored temperature value exceeds a threshold temperature range; monitoring the temperature of the memory component of the memory sub-system to determine that the temperature of the memory component corresponds to a second monitored temperature value that is within the threshold temperature range; and rewriting the data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the second monitored temperature value.

Abstract: Provided herein are polynucleotides, rAAV vectors, pharmaceutical compositions, and methods of making and using the same, e.g., for treatment of cystic fibrosis (CF). For example, the disclosure provides a recombinant adeno-associated vims (rAAV) that includes, in one embodiment, an AV.TL65 capsid protein and a polynucleotide that includes an F5 enhancer and a tg83 promoter operably linked to a CFTR?R minigene, pharmaceutical compositions thereof, and methods of use thereof, e.g., for treatment of CF.

Abstract: The disclosure provides methods of expressing a transgene in a cell, methods of treating disorders in a subject in need thereof, and pharmaceutical compositions. In particular, the methods involve contacting a cell (e.g., a cell of a subject suffering from a disorder such as cystic fibrosis) with a recombinant adeno-associated virus (rAAV) that includes, in one embodiment, an AV.TL65 capsid protein and a polynucleotide that includes a transgene in combination with an augmenter of AAV transduction, thereby expressing the transgene in the cell. The disclosure also provides pharmaceutical compositions that include an rAAV that includes, in one embodiment, an AV.TL65 capsid protein and a polynucleotide including a transgene in combination with one or more augmenters.

Abstract: A laser level includes a level body, the level body including a body housing and a laser light source contained in the body housing, the laser light source configured to emit a laser light beam plane so as to project a laser light line on a target surface, the laser light beam plane configured to form an adjustable angle relative to a horizontal plane, and the laser level including a fixing structure configured to fix the laser light source such that the laser light beam plane projected therefrom is fixed at an adjusted angle, the laser light line providing a levelling height when in a horizontal state. The laser level further includes an adjustment means configured to adjust the attitude of the laser light source when the laser light line projected onto the target surface from the laser light source from a non-horizontal state to a horizontal state.

Abstract: A method includes monitoring a temperature of a memory component of a memory sub-system to determine that the temperature of the memory component corresponds to a first monitored temperature value; writing data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the first monitored temperature value; determining that the first monitored temperature value exceeds a threshold temperature range; monitoring the temperature of the memory component of the memory sub-system to determine that the temperature of the memory component corresponds to a second monitored temperature value that is within the threshold temperature range; and rewriting the data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the second monitored temperature value.

Abstract: A levelling apparatus includes a housing, a light generation unit, at least one first lens, a second lens, and a holding apparatus. The light generation unit is arranged in the housing, is mounted in an oscillating manner relative to the housing and has at least one light source, to which the at least one first lens for generating a first light plane and the second lens for generating a second light plane are assigned. The holding apparatus includes a first holding element and a second holding element for arranging the at least one first lens and the second lens. The at least one first lens is arranged on the first holding element and the second lens is arranged on the second holding element. The holding apparatus is configured to orient the at least one first lens and the second lens at least substantially perpendicular to one another.

Abstract: Devices and techniques for variable width superblock addressing are described herein. A superblock width, specified in number of planes, is obtained. A superblock entry is created in a translation table of a NAND device. Here, the superblock entry may include a set of blocks, from the NAND device, that have the same block indexes across multiple die of the NAND device. The number of unique block indexes are equal to the number of planes and in different planes. A request, received from a requesting entity, is performed using the superblock entry. Performing the request includes providing a single instruction to multiple die of the NAND device and multiple data segments. Here, a data segment corresponds to a block in the set of blocks specified by a tuple of block index and die. A result of the request is then returned to the requesting entity.

Abstract: A levelling apparatus includes a housing, a light generation unit, at least one first lens, a second lens, and a holding apparatus. The light generation unit is arranged in the housing, is mounted in an oscillating manner relative to the housing and has at least one light source, to which the at least one first lens for generating a first light plane and the second lens for generating a second light plane are assigned. The holding apparatus includes a first holding element and a second holding element for arranging the at least one first lens and the second lens. The at least one first lens is arranged on the first holding element and the second lens is arranged on the second holding element. The holding apparatus is configured to orient the at least one first lens and the second lens at least substantially perpendicular to one another.

Abstract: A method for modifying a low-cost small form factor pluggable optical-electrical bidirectional transceiver (hereinafter “SFP transceiver”) by converting the SFP transceiver into a dual-in-line package. Such conversion enables the SFP transceiver to be soldered directly on a printed circuit board of a line replaceable unit of an avionics system, thereby eliminating the concern that the SFP transceiver may become detached due to vibration during aircraft operation. The method also includes a sealing process to protect the contact pads on the SFP transceiver, thereby eliminating any concern that the contact pads could corrode due to long-term moisture and humidity exposure. The product of the method is a ruggedized SFP transceiver capable of withstanding the rigors of operating in a harsh avionics environment onboard an aircraft.

Abstract: A fuel sensing system utilizes a fiber optic sensor comprising a membrane made of a direct band gap semiconductor material (such as gallium arsenide) that forms an optical cavity with an optical fiber inside a hermetically sealed sensor package located at the bottom of a fuel tank. The optical fiber inside the fuel tank is not exposed to the fuel. The optical cavity formed by the bottom surface of the membrane and the surface of the distal end of the internal optical fiber is capable of behaving as a Fabry-Pérot interferometer. Multiple light sources operating at different wavelengths and multiple spectrometers can be coupled to the confronting surface of the membrane via the optical fiber inside the fuel tank, a hermetically sealed fiber optic connector that passes through the wall of the fuel tank, and a fiber optic coupler located outside the fuel tank.

Abstract: A free-space laser communication system for bidirectional transmission of telemetry data in Gigabit Ethernet (GBE) protocol using a dual atmospheric effect mitigation approach. This free-space bidirectional GBE laser communication system utilizes an Optical Combining Receiver Array and a Framer/Forward Error Correction/Interleaver (FFI) device to mitigate the combined effects of atmospheric turbulence and channel fading. Since the FFI device is designed for Synchronous Optical Network (SONET) protocol, an intelligent (or smart) media converter is used to convert GBE telemetry data to SONET frames, which enables the FFI device to perform an error correction algorithm and provide a seamless error-free GBE laser communication link for distance over a kilometer. This bidirectional laser communication system can be implemented with low-cost commercially available components.

Abstract: A fuel sensing system utilizes a fiber optic sensor comprising a membrane made of a direct band gap semiconductor material (such as gallium arsenide) that forms an optical cavity with an optical fiber inside a hermetically sealed sensor package located at the bottom of a fuel tank. The optical fiber inside the fuel tank is not exposed to the fuel. The optical cavity formed by the bottom surface of the membrane and the surface of the distal end of the internal optical fiber is capable of behaving as a Fabry-Pérot interferometer. Multiple light sources operating at different wavelengths and multiple spectrometers can be coupled to the confronting surface of the membrane via the optical fiber inside the fuel tank, a hermetically sealed fiber optic connector that passes through the wall of the fuel tank, and a fiber optic coupler located outside the fuel tank.

Abstract: An apparatus comprises a substrate having a type of conductivity, an intrinsic region above the substrate, and a metal layer on a portion of the surface of the intrinsic region. The intrinsic region has a surface. The metal layer may have a thickness that is configured to allow a plurality of photons to pass through the metal layer into the intrinsic region and form a rectifying contact with the intrinsic region.

Abstract: An apparatus comprises an optical transmitter; an optical detector configured to receive optical signals from an optical fiber; an optical splitter having a first port, a second port coupled to the optical detector by the optical fiber, and a third port coupled to the optical transmitter; and a two stage amplifier system connected to an output of the optical detector. An input surface of the optical detector may have a diameter that is substantially equal to a diameter of a core in the optical fiber. The diameter of the input surface of the optical detector reduces capacitance and reduces signal distortion. The optical splitter may be configured to receive a first optical signal at the first port. The optical splitter may be configured to send the first optical signal to the second port and send a second optical signal received at the third port to the first port.