Abstract: Methods, systems, and devices for zone writing and maintenance for memory systems are described. A memory system may support a zoned write operation, where data associated with a preferred zone may be written with a first cursor, and data associated with other zones may be written with one or more second cursors. For example, a zone associated with a highest access frequency may be written using a single-level cell cursor, and other zones may be written using a higher-level cursor, such as a triple-level cursor. After writing the zones to a quantity of virtual blocks, a maintenance operation may be performed to reorder the zones within the quantity of virtual blocks according to access frequencies of the zones. Additionally, performing the maintenance operation may include performing garbage collection for the zones, such that invalid zones may be erased and valid zones may be reconsolidated within the quantity of virtual blocks.

Abstract: Provided herein are methods for treatment of cystic fibrosis (CF), including for patients with class I CFTR mutations. The methods may involve administration of a recombinant adeno-associated virus (rAAV) that includes an AV.TL65 capsid protein and a polynucleotide that includes an F5 enhancer and a tg83 promoter operably linked to a CFTR?R minigene, or a pharmaceutical composition thereof.

Abstract: Provided herein are methods of transducing a recombinant viral, e.g., retroviral, vector, improving the transgene expression from a recombinant viral vector, and reducing titers of neutralizing antibodies that bind a recombinant viral vector. In general, these methods include administering to a subject a recombinant viral vector and an effective amount of an immunosuppressive regimen.

Abstract: A laser level includes a level body, the level body including a body housing and a laser light source contained in the body housing, the laser light source configured to emit a laser light beam plane so as to project a laser light line on a target surface, the laser light beam plane configured to form an adjustable angle relative to a horizontal plane, and the laser level including a fixing structure configured to fix the laser light source such that the laser light beam plane projected therefrom is fixed at an adjusted angle, the laser light line providing a levelling height when in a horizontal state. The laser level further includes an adjustment means configured to adjust the attitude of the laser light source when the laser light line projected onto the target surface from the laser light source from a non-horizontal state to a horizontal state.

Abstract: A method includes monitoring a temperature of a memory component of a memory sub-system to determine that the temperature of the memory component corresponds to a first monitored temperature value; writing data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the first monitored temperature value; determining that the first monitored temperature value exceeds a threshold temperature range; monitoring the temperature of the memory component of the memory sub-system to determine that the temperature of the memory component corresponds to a second monitored temperature value that is within the threshold temperature range; and rewriting the data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the second monitored temperature value.

Abstract: A method includes monitoring a temperature of a memory component of a memory sub-system to determine that the temperature of the memory component corresponds to a first monitored temperature value; writing data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the first monitored temperature value; determining that the first monitored temperature value exceeds a threshold temperature range; monitoring the temperature of the memory component of the memory sub-system to determine that the temperature of the memory component corresponds to a second monitored temperature value that is within the threshold temperature range; and rewriting the data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the second monitored temperature value.

Abstract: A method includes monitoring a temperature of a memory component of a memory sub-system to determine that the temperature of the memory component corresponds to a first monitored temperature value; writing data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the first monitored temperature value; determining that the first monitored temperature value exceeds a threshold temperature range; monitoring the temperature of the memory component of the memory sub-system to determine that the temperature of the memory component corresponds to a second monitored temperature value that is within the threshold temperature range; and rewriting the data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the second monitored temperature value.

Abstract: Provided herein are polynucleotides, rAAV vectors, pharmaceutical compositions, and methods of making and using the same, e.g., for treatment of cystic fibrosis (CF). For example, the disclosure provides a recombinant adeno-associated vims (rAAV) that includes, in one embodiment, an AV.TL65 capsid protein and a polynucleotide that includes an F5 enhancer and a tg83 promoter operably linked to a CFTR?R minigene, pharmaceutical compositions thereof, and methods of use thereof, e.g., for treatment of CF.

Abstract: The disclosure provides methods of expressing a transgene in a cell, methods of treating disorders in a subject in need thereof, and pharmaceutical compositions. In particular, the methods involve contacting a cell (e.g., a cell of a subject suffering from a disorder such as cystic fibrosis) with a recombinant adeno-associated virus (rAAV) that includes, in one embodiment, an AV.TL65 capsid protein and a polynucleotide that includes a transgene in combination with an augmenter of AAV transduction, thereby expressing the transgene in the cell. The disclosure also provides pharmaceutical compositions that include an rAAV that includes, in one embodiment, an AV.TL65 capsid protein and a polynucleotide including a transgene in combination with one or more augmenters.

Abstract: A laser level includes a level body, the level body including a body housing and a laser light source contained in the body housing, the laser light source configured to emit a laser light beam plane so as to project a laser light line on a target surface, the laser light beam plane configured to form an adjustable angle relative to a horizontal plane, and the laser level including a fixing structure configured to fix the laser light source such that the laser light beam plane projected therefrom is fixed at an adjusted angle, the laser light line providing a levelling height when in a horizontal state. The laser level further includes an adjustment means configured to adjust the attitude of the laser light source when the laser light line projected onto the target surface from the laser light source from a non-horizontal state to a horizontal state.

Abstract: A method includes monitoring a temperature of a memory component of a memory sub-system to determine that the temperature of the memory component corresponds to a first monitored temperature value; writing data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the first monitored temperature value; determining that the first monitored temperature value exceeds a threshold temperature range; monitoring the temperature of the memory component of the memory sub-system to determine that the temperature of the memory component corresponds to a second monitored temperature value that is within the threshold temperature range; and rewriting the data to the memory component of the memory sub-system while the temperature of the memory component corresponds to the second monitored temperature value.

Abstract: A levelling apparatus includes a housing, a light generation unit, at least one first lens, a second lens, and a holding apparatus. The light generation unit is arranged in the housing, is mounted in an oscillating manner relative to the housing and has at least one light source, to which the at least one first lens for generating a first light plane and the second lens for generating a second light plane are assigned. The holding apparatus includes a first holding element and a second holding element for arranging the at least one first lens and the second lens. The at least one first lens is arranged on the first holding element and the second lens is arranged on the second holding element. The holding apparatus is configured to orient the at least one first lens and the second lens at least substantially perpendicular to one another.

Abstract: Devices and techniques for variable width superblock addressing are described herein. A superblock width, specified in number of planes, is obtained. A superblock entry is created in a translation table of a NAND device. Here, the superblock entry may include a set of blocks, from the NAND device, that have the same block indexes across multiple die of the NAND device. The number of unique block indexes are equal to the number of planes and in different planes. A request, received from a requesting entity, is performed using the superblock entry. Performing the request includes providing a single instruction to multiple die of the NAND device and multiple data segments. Here, a data segment corresponds to a block in the set of blocks specified by a tuple of block index and die. A result of the request is then returned to the requesting entity.

Abstract: A levelling apparatus includes a housing, a light generation unit, at least one first lens, a second lens, and a holding apparatus. The light generation unit is arranged in the housing, is mounted in an oscillating manner relative to the housing and has at least one light source, to which the at least one first lens for generating a first light plane and the second lens for generating a second light plane are assigned. The holding apparatus includes a first holding element and a second holding element for arranging the at least one first lens and the second lens. The at least one first lens is arranged on the first holding element and the second lens is arranged on the second holding element. The holding apparatus is configured to orient the at least one first lens and the second lens at least substantially perpendicular to one another.

Abstract: This invention is directed to methods for controlling the duration of the depolarization and repolarization of the cardiac ventricle and therefore the QT interval, in therapeutically useful ways in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof: wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl, wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano.

Abstract: This invention is directed to methods for controlling the duration of the depolarization and repolarization of the cardiac ventricle and therefore the QT interval, in therapeutically useful ways in a subject, comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II), or a pharmaceutically acceptable salt or ester thereof: wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl, wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano.