Patents by Inventor Eric Zinn

Eric Zinn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR MODULATING THE INTERACTION BETWEEN ADENO-ASSOCIATED VIRUS (AAV) AND THE AAV RECEPTOR (AAVR) FOR ALTERED BIO-DISTRIBUTION OF AAV
    Publication number: 20240060087
    Abstract: This disclosure describes compositions and methods for altering the bio-distribution of adeno-associated viruses (AAVs) in subjects.
    Type: Application
    Filed: January 7, 2022
    Publication date: February 22, 2024
    Inventors: Eric Zinn, Christopher Tipper, Luk H. Vandenberghe
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20230287359
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: April 27, 2023
    Publication date: September 14, 2023
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • ALTERING TISSUE TROPISM OF ADENO-ASSOCIATED VIRUSES
    Publication number: 20230051611
    Abstract: This disclosure provides compositions and methods for altering or changing the tissue tropism, e.g., liver tropism, of adeno-associated viruses (AAV).
    Type: Application
    Filed: May 10, 2019
    Publication date: February 16, 2023
    Inventors: Luk H. Vandenberghe, Pauline Schmit, Christopher Tipper, Carmen Unzu, Eric Zinn
  • METHODS AND COMPOSITIONS FOR MODULATING THE INTERACTION BETWEEN ADENO-ASSOCIATED VIRUS (AAV) AND THE AAV RECEPTOR (AAVR) FOR ALTERED BIO-DISTRIBUTION OF AAV
    Publication number: 20220411820
    Abstract: This disclosure describes compositions and methods for altering the bio-distribution of adeno-associated viruses (AAVs) in subjects.
    Type: Application
    Filed: September 9, 2020
    Publication date: December 29, 2022
    Inventors: Eric Zinn, Christopher Tipper, Luk H. Vandenberghe
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 11466258
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: October 11, 2022
    Assignees: The Schepens Eye Research Institute, Inc., Massachusetts Eye and Ear Infirmary
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20220017875
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: August 20, 2021
    Publication date: January 20, 2022
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 11104885
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: August 31, 2021
    Assignees: The Schepens Eye Research Institute, Inc., Massachusetts Eye and Ear Infirmary
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • METHODS OF MAKING AND USING COMBINATORIAL BARCODED NUCLEIC ACID LIBRARIES HAVING DEFINED VARIATION
    Publication number: 20210156048
    Abstract: This disclosure describes compositions, methods, and systems for constructing defined variation in a contiguous functional genetic unit in association with a unique sequence identifier (“a barcode”) in a combinatorial manner.
    Type: Application
    Filed: April 5, 2019
    Publication date: May 27, 2021
    Inventors: Luk H. Vandenberghe, Eric Zinn, Heikki Turunen
  • Ancestral Virus Sequences and Uses Thereof
    Publication number: 20210017235
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: August 10, 2020
    Publication date: January 21, 2021
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20200318082
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: June 19, 2020
    Publication date: October 8, 2020
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Ancestral virus sequences and uses thereof
    Patent number: 10738087
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: August 11, 2020
    Assignees: Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20200123504
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: December 17, 2019
    Publication date: April 23, 2020
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 10526584
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: January 7, 2020
    Assignees: The Schepens Eye Research Institute, Inc., Massachusetts Eye and Ear Infirmary
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Ancestral Virus Sequences and Uses Thereof
    Publication number: 20190100560
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen opeiably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: July 29, 2016
    Publication date: April 4, 2019
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20190055524
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: November 2, 2018
    Publication date: February 21, 2019
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 10119125
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: November 6, 2018
    Assignees: Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20170298323
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: June 26, 2017
    Publication date: October 19, 2017
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 9719070
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: August 1, 2017
    Assignees: Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • Methods of predicting ancestral virus sequences and uses thereof
    Patent number: 9695220
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: July 4, 2017
    Assignees: Massachusetts Eye & Ear Infirmary, Schepens Eye Research Institute
    Inventors: Luk H. Vandenberghe, Eric Zinn
  • METHODS OF PREDICTING ANCESTRAL VIRUS SEQUENCES AND USES THEREOF
    Publication number: 20170051257
    Abstract: Methods are described for predicting ancestral sequences for viruses or portions thereof. Also described are predicted ancestral sequences for adeno-associated virus (AAV) capsid polypeptides. The disclosure also provides methods of gene transfer and methods of vaccinating subjects by administering a target antigen operably linked to the AAV capsid polypeptides.
    Type: Application
    Filed: October 12, 2016
    Publication date: February 23, 2017
    Inventors: Luk H. Vandenberghe, Eric Zinn