Patents by Inventor Erica Dawson Tenent
Erica Dawson Tenent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10539497Abstract: A method and a flow cytometer system in which a light path is aligned to optimally direct light from a light source to a flow cell of a flow cytometer instrument are provided. The flow cytometer may include an orientable mirror disposed in the light path between the light source and the flow cell. By changing an orientation of the mirror through a sequence of different orientations, an optimal orientation of the mirror may be determined, and the mirror may be oriented accordingly before proceeding to conduct a flow cytometry investigation.Type: GrantFiled: June 2, 2015Date of Patent: January 21, 2020Assignee: Essen Instruments, Inc.Inventors: Andrew W. Smolak, Erica Dawson Tenent, Kathy L. Rowlen, Garrett S. Wilson, Christopher H. Converse, Evan M. Toth
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Patent number: 10520420Abstract: Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.Type: GrantFiled: November 30, 2018Date of Patent: December 31, 2019Assignee: Essen Instruments, Inc.Inventors: Andrew W. Smolak, Jean-Luc Fraikin, Erica Dawson Tenent, Kathy L. Rowlen
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Publication number: 20190094122Abstract: Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.Type: ApplicationFiled: November 30, 2018Publication date: March 28, 2019Inventors: Andrew W. Smolak, Jean-Luc Fraikin, Erica Dawson Tenent, Kathy L. Rowlen
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Patent number: 10184878Abstract: Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.Type: GrantFiled: January 15, 2018Date of Patent: January 22, 2019Assignee: IntelliCyt CorporationInventors: Andrew W. Smolak, Jean-Luc Fraikin, Erica Dawson Tenent, Kathy L. Rowlen
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Publication number: 20180330056Abstract: The invention provides microarray systems and methods for pathogen identification and characterization. Aspects of the invention implement supervised learning for microarray data analysis to enhance the accuracy and scope of genomic and diagnostic information obtained. Embodiments of the invention, for example, utilize structured logical combinations of the output of independent supervised learning algorithms, such as artificial neural network (ANN) algorithms, to provide an efficient and rapid pathway to clinically and epidemiologically relevant diagnostic information.Type: ApplicationFiled: June 30, 2016Publication date: November 15, 2018Inventors: Robert STOUGHTON, Amber W. TAYLOR, Andrew W. SMOLAK, Erica Dawson TENENT, Rebecca H. BLAIR, Kathy L. ROWLEN
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Publication number: 20180187273Abstract: Provided herein is a multiplexed RT-PCR based assay for amplification multiple whole gene segments of influenza A and B. Accordingly, various oligonucleotide primers are disclosed, including for use in a multiplex RT-PCR process for influenza detection and characterization. The primers and instructions for use may be provided in the form of a kit. Applications for the primers and related methods include as a clinical virology tool, epidemiological and surveillance tool, as well as in animal surveillance testing for influenza viruses.Type: ApplicationFiled: June 30, 2016Publication date: July 5, 2018Inventors: Amber W. TAYLOR, Erica Dawson TENENT, Kathy L. ROWLEN
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Publication number: 20180136108Abstract: Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.Type: ApplicationFiled: January 15, 2018Publication date: May 17, 2018Inventors: Andrew W. Smolak, Jean-Luc Fraikin, Erica Dawson Tenent
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Patent number: 9903803Abstract: Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.Type: GrantFiled: June 3, 2015Date of Patent: February 27, 2018Assignee: Intellicyt CorporationInventors: Andrew W. Smolak, Jean-Luc Fraikin, Erica Dawson Tenent, Kathy L. Rowlen
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Patent number: 9850979Abstract: A flow cytometer may include a vibration isolation structure on which a flow cytometer optical system assembly is supported when the flow cytometer is in an operational configuration. A shear protection structure may be positioned to protect a vibration isolation structure from damage during handling and shipping. A flow cytometer optical system assembly may include optical component units fixed in position on a support platform with adjustability of one or more optical features in the optical component units. A light-tight dichroic mirror unit may include a rotatably mounted dichroic mirror with a locking mechanism to permit re-setting angular positioning of a dichroic mirror.Type: GrantFiled: June 2, 2015Date of Patent: December 26, 2017Assignee: IntelliCyt CorporationInventors: Kathy L. Rowlen, Erica Dawson Tenent, Garrett S. Wilson, Christopher H. Converse
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Publication number: 20170205331Abstract: Methods of evaluating particle attributes in a sample fluid subjected to flow cytometry investigation in a flow cytometer instrument, methods of processing time series signal data traces output by a flow cytometer instrument, and a flow cytometer system are provided. In the methods and systems, data points comprising time series signal data traces corresponding with detection during the flow cytometry investigation of light from the sample fluid in one or more wavelength ranges indicative of the presence of one or more particle attributes in the sample fluid are batch-processed using a batch-specific signal peak threshold determined as a function of a batch-specific noise characteristic to identify signal peaks in the batch of data points indicative of the presence of the one or more particle attributes in the sample fluid.Type: ApplicationFiled: June 3, 2015Publication date: July 20, 2017Inventors: Andrew W. Smolak, Jean-Luc Fraikin, Erica Dawson Tenent, Kathy L. Rowlen
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Publication number: 20170198782Abstract: A flow cytometer may include a vibration isolation structure on which a flow cytometer optical system assembly is supported when the flow cytometer is in an operational configuration. A shear protection structure may be positioned to protect a vibration isolation structure from damage during handling and shipping. A flow cytometer optical system assembly may include optical component units fixed in position on a support platform with adjustability of one or more optical features in the optical component units. A light-tight dichroic mirror unit may include a rotatably mounted dichroic mirror with a locking mechanism to permit re-setting angular positioning of a dichroic mirror.Type: ApplicationFiled: June 2, 2015Publication date: July 13, 2017Applicant: VIROCYT, INC.Inventors: Kathy L. ROWLEN, Erica Dawson TENENT, Garrett S. WILSON, Christopher H. CONVERSE
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Publication number: 20170115203Abstract: A method and a flow cytometer system in which a light path is aligned to optimally direct light from a light source to a flow cell of a flow cytometer instrument are provided. The flow cytometer may include an orientable mirror disposed in the light path between the light source and the flow cell. By changing an orientation of the mirror through a sequence of different orientations, an optimal orientation of the mirror may be determined, and the mirror may be oriented accordingly before proceeding to conduct a flow cytometry investigation.Type: ApplicationFiled: June 2, 2015Publication date: April 27, 2017Inventors: Andrew W. SMOLAK, Erica Dawson TENENT, Kathy L. ROWLEN, Garrett S. WILSON, Christopher H. CONVERSE, Evan M. TOTH
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Patent number: 9546936Abstract: In a method for processing biological materials for flow cytometry evaluation for virus particles, a mixture including biological material and purification particles is centrifuged to prepare a centrifuged composition including a supernatant that may be further processed prior to the flow cytometry evaluation. The purification particles include porous cores functionalized to capture smaller-size impurities in a biological material sample and a porous size-exclusion shell surrounding the core to exclude larger-size components of the biological material from entering into the core. Multiple samples may be processed in multi-sample processing units. A product may contain a sealed container with the unit quantity of purification particle in a storage liquid and a kit may include such a sealed container and a centrifugal filter.Type: GrantFiled: November 20, 2015Date of Patent: January 17, 2017Assignee: VIROCYT, INC.Inventors: Kathy L. Rowlen, Erica Dawson Tenent, Lauren R. Wolfe
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Publication number: 20160076981Abstract: In a method for processing biological materials for flow cytometry evaluation for virus particles, a mixture including biological material and purification particles is centrifuged to prepare a centrifuged composition including a supernatant that may be further processed prior to the flow cytometry evaluation. The purification particles include porous cores functionalized to capture smaller-size impurities in a biological material sample and a porous size-exclusion shell surrounding the core to exclude larger-size components of the biological material from entering into the core. Multiple samples may be processed in multi-sample processing units. A product may contain a sealed container with the unit quantity of purification particle in a storage liquid and a kit may include such a sealed container and a centrifugal filter.Type: ApplicationFiled: November 20, 2015Publication date: March 17, 2016Inventors: Kathy L. Rowlen, Erica Dawson Tenent, Lauren R. Wolfe
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Publication number: 20150232911Abstract: In a method for processing biological materials for flow cytometry evaluation for virus particles, a mixture including biological material and purification particles is centrifuged to prepare a centrifuged composition including a supernatant that may be further processed prior to the flow cytometry evaluation. The purification particles include porous cores functionalized to capture smaller-size impurities in a biological material sample and a porous size-exclusion shell surrounding the core to exclude larger-size components of the biological material from entering into the core. Multiple samples may be processed in multi-sample processing units. A product may contain a sealed container with the unit quantity of purification particle in a storage liquid and a kit may include such a sealed container and a centrifugal filter.Type: ApplicationFiled: June 26, 2014Publication date: August 20, 2015Inventors: Kathy L. Rowlen, Erica Dawson Tenent, Lauren R. Wolfe