Abstract: Methods for generating a report of genomic and medical information associated with a patient are described. The methods may comprise, for example, receiving genomic testing data associated with the patient. The methods may comprise, for example, based on the genomic testing data, retrieving medical information including one or more potential clinical treatments for the patient. The methods may comprise, for example, determining that the medical information has at least some clinical significance to the patient. The methods may comprise, for example, based on at least a portion of the medical information having at least some clinical significance to the patient, generating patient-specific medical data. The methods may comprise, for example, determining at least one specific position to dispose the medical information on the report based on the patient-specific medical data and generating the report based on the determined at least one specific position.

Abstract: Methods for reporting clinically-actionable potential germline pathogenic variants identified in nucleic acid sequencing data are described. The methods may comprise, for example, receiving variant sequence data for a sample from a subject; filtering the variant sequence data to identify variant sequences located in a gene locus known to comprise clinically-actionable germline variants; filtering the variant sequences identified as being located in such a gene locus to identify those that are potentially germline pathogenic; filtering the resulting list of potentially germline pathogenic variant sequences to identify those that have an allele frequency greater than a first predetermined threshold; and based on a determination that a potentially germline pathogenic variant sequence has an allele frequency greater than the first predetermined threshold, reporting the variant sequence as a clinically-actionable potential germline pathogenic variant.

Abstract: NTRK fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing, and/or treating a subject having a cancer are disclosed.