Patents by Inventor Erica Maria Gerarda Aussems-Custers

Erica Maria Gerarda Aussems-Custers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chelating amphiphilic polymers
    Patent number: 9718929
    Abstract: Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T1/T2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: August 1, 2017
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Holger Gruell, Anke De Vries, Sander Langereis, Johan Lub, Erica Maria Gerarda Aussems-Custers
  • Lipid bilayer carrier for drugs or imaging agents
    Patent number: 9642802
    Abstract: Disclosed are carriers for drugs and/or MR imaging agents having a lipid bilayer shell comprising a phospholipid having two terminal alkyl chains, one being a short chain having a chain length of at most seven carbon atoms, the other being a long chain having a chain length of at least fifteen carbon atoms. The mixed long/short chain phospholipids serve to tune the release properties of the carrier. Preferred phospholipids are phosphatidylcholines.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: May 9, 2017
    Assignee: Koninklijke Philips N.V.
    Inventors: Sander Langereis, Holger Gruell, Mariska De Smet, Erica Maria Gerarda Aussems-Custers, Johan Lub
  • CHELATING AMPHIPHILIC POLYMERS
    Publication number: 20150247008
    Abstract: Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T1/T2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.
    Type: Application
    Filed: May 15, 2015
    Publication date: September 3, 2015
    Inventors: HOLGER GRUELL, ANKE DE VRIES, SANDER LANGEREIS, JOHAN LUB, ERICA MARIA GERARDA AUSSEMS-CUSTERS
  • LIPID BILAYER CARRIER FOR DRUGS OR IMAGING AGENTS
    Publication number: 20130108551
    Abstract: Disclosed are carriers for drugs and/or MR imaging agents having a lipid bilayer shell comprising a phospholipid having two terminal alkyl chains, one being a short chain having a chain length of at most seven carbon atoms, the other being a long chain having a chain length of at least fifteen carbon atoms. The mixed long/short chain phospholipids serve to tune the release properties of the carrier. Preferred phospholipids are phosphatidylcholines.
    Type: Application
    Filed: July 8, 2011
    Publication date: May 2, 2013
    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.
    Inventors: Sander Langereis, Holger Gruell, Mariska De Smet, Erica Maria Gerarda Aussems-Custers, Johan Lub