Abstract: An isolated polypeptide comprising a peptide which consists of a legless homology domain (HD); wherein the peptide inhibits Lgs function in colon cancer cells; and a composition comprising the same, are disclosed.

Abstract: The present invention relates to a new essential downstream component of the Wnt/Wingless (Wnt/Wg) signaling pathway and therapeutic and diagnostic applications based thereon. The invention relates to nucleotide sequences of the Drosophila melanogaster legless (lgs) gene, of its encoded proteins, as well as derivatives (e.g., fragments) and analogues thereof. The invention further includes vertebrate and invertebrate homologues of the Lgs protein, comprising proteins that contain a contiguous stretch of amino acids with similarity to the Drosophila lgs gene. The invention further relates to the function of the Drosophila and the human Lgs proteins. Methods for producing the Lgs proteins, derivatives and analogs, e.g., by recombinant means and antibodies to Lgs are provided by the present invention. In addition, the invention also relates to the therapeutic and diagnostic methods and compositions based on Lgs proteins and nucleic acids or fragments thereof.

Abstract: An isolated polypeptide comprising a peptide which consists of a legless homology domain (HD); wherein the peptide inhibits Lgs function in colon cancer cells; and a composition comprising the same, are disclosed.

Abstract: An isolated polypeptide comprising a peptide which consists of a legless homology domain (HD); wherein the peptide inhibits Lgs function in colon cancer cells; and a composition comprising the same, are disclosed.

Abstract: The present invention relates to a new essential downstream component of the Wnt/Wingless (Wnt/Wg) signaling pathway and therapeutic and diagnostic applications based thereon. The invention relates to nucleotide sequences of the Drosophila melanogaster legless (lgs) gene, of its encoded proteins, as well as derivatives (e.g., fragments) and analogues thereof. The invention further includes vertebrate and invertebrate homologues of the Lgs protein, comprising proteins that contain a contiguous stretch of amino acids with similarity to the Drosophila lgs gene. The invention further relates to the function of the Drosophila and the human Lgs proteins. Methods for producing the Lgs proteins, derivatives and analogs, e.g., by recombinant means and antibodies to Lgs are provided by the present invention. In addition, the invention also relates to the therapeutic and diagnostic methods and compositions based on Lgs proteins and nucleic acids or fragments thereof.

Abstract: The present invention relates to a new essential downstream component of the Wnt/Wingless (Wnt/Wg) signaling pathway and therapeutic and diagnostic applications based thereon. The invention relates to nucleotide sequences of the Drosophila melanogaster legless (lgs) gene, of its encoded proteins, as well as derivatives (e.g., fragments) and analogues thereof. The invention further includes vertebrate and invertebrate homologues of the Lgs protein, comprising proteins that contain a contiguous stretch of amino acids with similarity to the Drosophila lgs gene. The invention further relates to the function of the Drosophila and the human Lgs proteins. Methods for producing the Lgs proteins, derivatives and analogs, e.g., by recombinant means and antibodies to Lgs are provided by the present invention. In addition, the invention also relates to the therapeutic and diagnostic methods and compositions based on Lgs proteins and nucleic acids or fragments thereof.

Abstract: Hydrophilic, crosslinked organopolysiloxanes are obtained from the polymerization of hydroxyalkylmethacrylate and/or hydroxalkylacrylate in the presence of an organopolysiloxane containing at least 40 mol percent of monoorganosiloxane units.

Abstract: Impregnated wood containing a polymer which is produced in the wood from the polymerization of a monomer and/or prepolymer having aliphatic multiple bonds and crosslinked organopolysiloxanes.The polymer impregnated wood is prepared by impregnating the wood with a mixture containing a monomer and/or prepolymer containing aliphatic multiple bonds which is capable of free radical polymerization and a crosslinkable organopolysiloxane and thereafter the monomer and/or prepolymer is polymerized and the organopolysiloxane is crosslinked in the wood.

Abstract: A process for preparing plastic wood which comprises impregnating wood with a mixture containing (1) an organopolysiloxane having groups which are capable of condensation and/or containing SiC-bonded alkenyl group having an average molecular weight of at least 500 when the organopolysiloxane contains from 0.5 to 1.89 SiC-bonded organic radicals for each silicon atom and when the organopolysiloxane (1) contains from 1.90 to 2 SiC-bonded organic radicals for each silicon atom, then the average molecular weight is at least 20,000 and (2) an organic silicon compound having at least three groups which are capable of condensation and/or atoms capable of condensation and a maximum of 10 silicon atoms per molecule; and other substances if desired; and thereafter crosslinking the organopolysiloxane (1) having groups capable of condensation and/or containing SiC-bonded alkenyl groups, which is present in the wood.

Abstract: Organopolysiloxane compositions which are stable at room temperature, but are curable when subjected to elevated temperatures comprising (1) an organosilicon compound containing Si-bonded hydrogen, (2) an organosilicon compound containing aliphatic multiple bonds, (3) a catalyst capable of promoting the addition of Si-bonded hydrogen to the aliphatic multiple bonds and (4) an organic compound as an additive containing at least one group of the formula ##STR1## in which the additive inhibits curing at room temperature.

Abstract: A process for preparing cross-linked, modified organopolysiloxanes which comprises polymerizing at least one monomer having at least one aliphatic multiple bond in the presence of a free radical initiator and at least one cross-linked organopolysiloxane containing at least 40 mol percent of monoorganosiloxane units. When the organopolysiloxane is not crosslinked, then the polymerization of the monomer having at least one aliphatic multiple bond is conducted in the presence of an organopolysiloxane having at least 40 mol percent mono-organosiloxane units, and a free radical initiator and a catalyst which promotes cross-linking of the organopolysiloxane.