Abstract: New substituted phenoxyalkanolamines and phenoxyalkanol-cycloalkylamines of the general formula I ##STR1## in which R.sup.1 and R.sup.2, which can be identical or different, denote alkyl groups with in each case 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together denote the group --(CH.sub.2).sub.n --, wherein n is the number 4 or 5, R.sup.3 denotes hydrogen, or an alkyl group or an acyl group with in each case 1 to 6 carbon atoms, R.sub.4 denotes an alkyl group with 1 to 4 carbon atoms or the cyclopropylmethyl group and R.sup.5 denotes hydrogen halogen or alkyl, and acid addiition salts thereof, have a cardioselective .beta..sub.1 -adrenolytic and hypotensive action. They can be used as medicaments for the treatment of angina pectoris, hypertension and arrhythmias.

Abstract: New substituted phenoxyalkanolamines and phenoxyalkanol-cycloalkylamines of the general formula I ##STR1## in which R.sup.1 and R.sup.2, which can be identical or different, denote alkyl groups with in each case 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together denote the group --(CH.sub.2).sub.n --, wherein n is the number 4 or 5, R.sup.3 denotes hydrogen, or an alkyl group or an acyl group with in each case 1 to 6 carbon atoms, R.sub.4 denotes an alkyl group with 1 to 4 carbon atoms or the cyclopropylmethyl group and R.sup.5 denotes hydrogen halogen or alkyl, and acid addition salts thereof, have a cardioselective .beta..sub.1 -adrenolytic and hypotensive action. They can be used as medicaments for the treatment of angina pectoris, hypertension and arrhythmias.

Abstract: Bicyclic lactams of the general formula I ##STR1## in which R.sup.1 and R.sup.2, which can be identical or different, denote a hydrogen atom or an alkyl group with 1 to 3 carbon atoms, R.sup.3 denotes an unsubstituted phenyl group or a phenyl group which is substituted by a halogen atom, one or two alkoxy groups, a methylenedioxo group or one or several hydroxyl groups, or denotes a pyridyl group, an indolyl group, a 1,2-benzisoxazolyl group which is optionally substituted by a halogen atom or the benzimidazol-2-one or 1,4-benzodioxane radical, R.sup.

Abstract: Pyrido[1,8]naphthyridinones of the general formula I ##STR1## in which R.sup.1 denotes hydrogen, a straight-chain or branched alkyl group having 1 to 6 carbon atoms, the phenyl group or a substituted phenyl group, a cycloalkyl group, a carboxyl group, an alkoxycarbonyl group, a carboxamide group or a cyano group,R.sup.2 denotes hydrogen or a straight-chain or branched alkyl group having 1 to 4 carbon atoms,R.sup.3 denotes hydrogen, a straight-chain or branched alkyl group having 1 to 4 carbon atoms, a carboxyl group, an alkoxycarbonyl group, a carboxamide group or a cyano group,R.sup.

Abstract: Substituted 4-fluoro-isoindolines of the general formula I ##STR1## in which R denotes hydrogen or an acyl group, and their tautomeric forms and their acid addition salts have an alpha.sub.2 -antagonistic action.

Abstract: Substituted 5-phenylthio-6-aminopyrimidinones of the general formula I ##STR1## in which R denotes an amino or hydroxyl group, and their tautomeric forms and acid addition salts thereof, have diuretic, saluretic and uricosuric actions. They can be used as medicaments for the treatment of hypertension, hyperuricemia and edemas.

Abstract: Substituted 5-phenylthio-6-aminopyrimidinones of the general formula I ##STR1## in which R denotes an amino or hydroxyl group, and their tautomeric forms and acid addition salts thereof, have diuretic, saluretic and uricosuric actions. They can be used as medicaments for the treatment of hypertension, hyperuricemia and edemas.

Abstract: New substituted tetrahydro-1H-pyrazolo[5,1-a]isoindoles of the formula I ##STR1## in which R.sup.1 denotes a hydrogen or halogen atom or an alkoxy group having 1 to 4 carbon atoms, R.sup.2, R.sup.3 and R.sup.4, which can be identical or different, denote a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or R.sup.2 and R.sup.3 together denote the ethylene group, and X denotes a nitrogen atom or a methine group, and their acid addition salts have a long-lasting hypertensive effect and can be used as anti-hypotensives.

Abstract: New isoindolin-2-yl-guanidines and isoindolin-2-yl-aminoimidazolines of the general formula ##STR1## in which R.sup.1 and R.sup.2 can be identical or different and either hydrogen or a halogen, alkyl, or alkoxy, each with 1 to 4 carbon atoms,R.sup.3 and R.sup.4 can be identical or different and either a hydrogen or an alkyl with 1 to 4 carbon atoms, andR.sup.5, R.sup.6, R.sup.7, and R.sup.8 can be identical or different and either hydrogen or an alkyl with 1 to 4 carbon atoms, or in whichR.sup.5 and R.sup.6 together represent the ethylene group,and their salts have an .alpha.-sympathomimetic and vasoconstrictive action that makes them appropriate as drugs for the treatment of hypotonic and rhinological states.

Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, halogen, or alkyl, R.sup.2 is halogen or alkyl, R.sup.3 is hydrogen, acyl, or saturated or unsaturated alkyl, R.sup.4 and R.sup.5 are individually hydrogen, or alkyl, wherein all alkyl and acyl groups are branched or straight-chain and each contains 1 to 4 carbon atoms, X is oxygen, nitrogen, or sulfur, Y is oxygen or nitrogen, and --X--Y-- is --O--N--, --N--O--, or --S--N--, or salts of the above, with certain exceptions. Methods of preparation of the compounds, as well as their use as anti-hypertensives are also disclosed.

Abstract: Substituted aryloxyamino propanols and pharmaceutically acceptable acid addition salts thereof according to the following formula ##STR1## wherein X is selected from oxygen and NH, R.sup.1 is selected from hydrogen, amino and acylamino having 1 to 8 carbon atoms, R.sup.2 is selected from isopropyl, tertiarybutyl, and 2-(3,4-dimethoxyphenethyl), are disclosed which are useful as anti-hypertensive and .beta.-adrenolytic agents. Also, substituted aryl azoles selected from 3-aryl pyrazoles and 5-aryl oxazoles having the formula ##STR2## wherein X and R.sup.1 are the same, and R.sup.3 is selected from hydrogen, the radical ##STR3## are disclosed which are useful in the preparation of the substituted aryloxyamino propanols of Formula I. Compositions containing the aryloxyamino propanols, and methods of preparation are also disclosed.

Abstract: A compound of the formula ##STR1## wherein R is a straight or branched chain alkyl group having 1 to 17 carbon atoms or a cycloalkyl group having 3 to 6 carbon atoms; as well as the physiologically acceptable acid addition salts thereof. A method of production of the compounds, pharmaceutical compositions containing them, and methods of use are also disclosed.The compounds of the present invention are useful in the treatment of angina pectoris, hypertension, and certain forms of arrhythmia.

Abstract: There is disclosed substituted alkenones of Formula I ##STR1## wherein R.sup.1 is alkyl or acylamino each having 1 to 4 carbon atoms, hydrogen, or halogen,R.sup.2 and R.sup.3 individually are hydrogen, methyl or ethyl,R.sup.4 is hydrogen or dimethoxyphenyl, andn is 1 or 2,or physiologically acceptable acid addition salts thereof. Intermediates are also disclosed, along with methods of preparation of both the intermediates and the end products.The end products are useful as .beta. adrenolytic and anti-hypertensive agents. They are useful in the treatment of angina pectoris, hypertension, and arrhythmia.

Abstract: There is disclosed substituted alkenones of Formula I ##STR1## wherein R.sup.1 is alkyl or acylamino each having 1 to 4 carbon atoms, hydrogen, or halogen,R.sup.2 and R.sup.3 individually are hydrogen, methyl or ethyl,R.sup.4 is hydrogen or dimethoxyphenyl, andn is 1 or 2,or physiologically acceptable acid addition salts thereof. Intermediates are also disclosed, along with methods of preparation of both the intermediates and the end products.The end products are useful as .beta. adrenolytic and anti-hypertensive agents. They are useful in the treatment of angina pectoris, hypertension, and arrhythmia.

Abstract: The present invention is directed to certain aminopyrimidines of the general formula ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are hydrogen, halogen, alkoxy, alkylthio, or alkyl having 1 to 4 carbon atoms, or cycloalkyl having 3 to 5 carbon atoms and R.sup.4 is hydrogen or an aliphatic or aromatic acyl group, as well as physiologically compatible acid addition salts thereof. Compounds of the present invention are useful as blood pressure lowering agents and in the treatment of glaucoma.

Abstract: A compound of the formula ##STR1## wherein R.sup.1 is chlorine, bromine, or methoxy; and R.sup.2, R.sup.3, and R.sup.4 are individually hydrogen or methyl, at least one of R.sup.2, R.sup.3, and R.sup.4 being hydrogen; or R.sup.2 and R.sup.3 together are an ethylene group and R.sup.4 is hydrogen, or a pharmaceutically acceptable acid addition salt thereof. Such compounds are useful as anti-hypertensive agents. Methods of preparation and certain novel intermediates are also disclosed.

Abstract: Aryl substituted furnaces and pharmaceutically acceptable acid addition salts thereof according to the following formula ##STR1## wherein R.sub.1 and R.sub.2 may be the same or different and are selected from hydrogen, halogen, alkyl and acylamino having 1 to 4 carbon atoms, R.sub.3 and R.sub.4 may be the same or different and are selected from hydrogen and methyl, R.sub.5 is selected from hydrogen, dimethoxyphenyl and acylamino having the following formulaR.sub.6 --CONH--wherein R.sub.6 is selected from alkyl having 1 to 4 carbon atoms, are disclosed which are useful as anti-hypertensive and .beta.-adrenolytic agents. Also, substituted furnaces having the formula ##STR2## wherein R.sub.7 is selected from hydrogen, benzyl, the radical ##STR3## and the radical ##STR4## wherein X is selected from chlorine and bromine, are disclosed which are useful in the preparation of the aryl substituted furnaces. Compositions containing the aryl substituted furnaces, and methods of preparation are also disclosed.

Abstract: Novel condensed nitrogen containing heterocyclic compounds and pharmaceutically acceptable acid addition salts thereof according to the following formula ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are selected from hydrogen, halogen, alkyl and alkoxy having one to four carbons, X is selected from oxygen, sulfur, methylene, imino and acylimino having two to five carbons in the acyl group, n and m are positive integers of 1, 2, or 3, and p is a positive integer of 2 or 3, are disclosed which are useful as anti hypertensive agents. Compositions containing said compounds and methods of preparation are also disclosed.

Abstract: The present invention is directed to novel peruvoside derivatives having the formula ##STR1## and the formula ##STR2## wherein R.sup.1 and R.sup.2 are the same or different and are selected from a hydrogen atom, an acyl group, an alkoxymethyl group and a carboalkoxy group wherein the alkyl portion of said groups has 1-4 carbon atoms and R.sup.3 is an acyl group having 2-5 carbon atoms. Methods of preparation and suitable compositions are also disclosed. Said compounds and compositions are useful for the treatment of cardiac insufficiencies.

Abstract: S (IV)-benzo-1,2,4-thiadiazines having the structure ##SPC1##Are disclosed. These compounds and their acid addition salts have been found to have anti-hypertensive and spasmolytic properties.