Abstract: Described herein is the synthesis of Bruton's tyrosine kinase (Btk) inhibitor 1-(R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl) piperidin-1-yl)prop-2-en-1-one.

Abstract: A content management system for collecting files from one or more submitters in a collection folder. A collector, who generates the collection folder, can invite one or more submitters to submit one or more files to the collection folder. The one or more submitters have limited rights to the collection folder. The limited rights can include uploading rights and prohibiting a submitter from viewing files that other submitters associated with the collection folder submitted. Thus, the collection folder is able to store files from the one or more submitters, but prevent them from viewing other's submissions.

Abstract: A content management system for collecting files from one or more submitters in a collection folder. A collector, who generates the collection folder, can invite one or more submitters to submit one or more files to the collection folder. The one or more submitters have limited rights to the collection folder. The limited rights can include uploading rights and prohibiting a submitter from viewing files that other submitters associated with the collection folder submitted. Thus, the collection folder is able to store files from the one or more submitters, but prevent them from viewing other's submissions.

Abstract: A content management system for collecting files from one or more submitters in a collection folder. A collector, who generates the collection folder, can invite one or more submitters to submit one or more files to the collection folder. The one or more submitters have limited rights to the collection folder. The limited rights can include uploading rights and prohibiting a submitter from viewing files that other submitters associated with the collection folder submitted. Thus, the collection folder is able to store files from the one or more submitters, but prevent them from viewing other's submissions.

Abstract: A content management system for collecting files from one or more submitters in a collection folder. A collector, who generates the collection folder, can invite one or more submitters to submit one or more files to the collection folder. The one or more submitters have limited rights to the collection folder. The limited rights can include uploading rights and prohibiting a submitter from viewing files that other submitters associated with the collection folder submitted. Thus, the collection folder is able to store files from the one or more submitters, but prevent them from viewing other's submissions.

Abstract: A telematics device coupled to vehicle onboard computer system calculates carbon dioxide output of the vehicle. The device uses inputs from existing vehicle performance and parameter sensors, such as speed, fuel efficiency, mass air flow and oxygen present in the vehicle's exhaust, to calculate carbon dioxide output. Speed divided by fuel efficiency results in gallons per hour. An emission factor, EF, multiplied by the gallons per hour results in weight of carbon dioxide produced by the vehicle per hour. Dividing EF by the efficiency results in pounds per mile. Using input from the mass air flow and oxygen sensors, with an approximation of gasoline molecular weight may produce more accurate results without using EF. If the sensors do not provide values in the units needed, a calibration curve for the mass air flow sensor and oxygen sensor may be used. The telematics device can display the results or upload them.

Abstract: A telematics device coupled to vehicle onboard computer system calculates carbon dioxide output of the vehicle. The device uses inputs from existing vehicle performance and parameter sensors, such as speed, fuel efficiency, mass air flow and oxygen present in the vehicle's exhaust, to calculate carbon dioxide output. Speed divided by fuel efficiency results in gallons per hour. An emmission factor, EF, multiplied by the gallons per hour results in weight of carbon dioxide produced by the vehicle per hour. Dividing EF by the efficiency results in pounds per mile. Using input from the mass air flow and oxygen sensors, with an approximation of gasoline molecular weight may produce more accurate results without using EF. If the sensors do not provide values in the units needed, a calibration curve for the mass air flow sensor and oxygen sensor may be used. The telematics device can display the results or upload them.

Abstract: A telematics device coupled to vehicle onboard computer system calculates carbon dioxide output of the vehicle. The device uses inputs from existing vehicle performance and parameter sensors, such as speed, fuel efficiency, mass air flow and oxygen present in the vehicle's exhaust, to calculate carbon dioxide output. Speed divided by fuel efficiency results in gallons per hour. An emmission factor, EF, multiplied by the gallons per hour results in weight of carbon dioxide produced by the vehicle per hour. Dividing EF by the efficiency results in pounds per mile. Using input from the mass air flow and oxygen sensors, with an approximation of gasoline molecular weight may produce more accurate results without using EF. If the sensors do not provide values in the units needed, a calibration curve for the mass air flow sensor and oxygen sensor may be used. The telematics device can display the results or upload them.

Abstract: Novel compounds of the general formulae (I) or (II), including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.

Abstract: Novel piperazin-2-one containing compounds of general formulae (I) or (II), including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivative having activity against mammalian factor Xa arc described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.