Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts therefor, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

Abstract: A tubular prosthesis including a tubular wall portion of loosely interlocked pattern, e.g. of knitted loops, constructed to function within a body lumen. The loops are preferably formed of co-knitted strand materials. A first strand material is a metal strand that structurally defines the tubular shape of the prosthesis and maintains the shape when positioned in the lumen. A second strand material is a predetermined substance selected to provide desired characteristics to the wall of the prosthesis.

Abstract: The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

Abstract: A stent for reinforcement of the lumen of a peristaltic organ is formed by knitting preferably a nitinol wire into a pattern of overlapping loops selected such that from a relaxed state each row of loops may shift axially relative to and independently of the rows on either side. This local lengthening and shortening accommodate peristalsis of the organ without migrating within the organ. A stent is also shown which comprises two resilient cylindrical mesh layers and a semi-permeable compliant membrane such as expanded polytetrafluoroethylene, sandwiched between. The two mesh layers may be knit of a flexible filament, and the knit may be configured so that the stent can adapt to peristalsis of the body lumen. A method is also shown of manufacturing a delivery system for a resilient tubular device such as a stent so that the device can be inserted into the body in a substantially reduced diameter. The method uses a confining block having a bore and a slot leading into the bore.

Abstract: The present invention relates to therapeutically active azaheterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment related to the GABA uptake.

Abstract: The invention features a catheter having a stylet that increases columnar strength and axial force transmission ("pushability") of the catheter shaft. This aspect of the invention features the stylet extending distally beyond an exit port which is used in rapid catheter exchange and being embedded in the catheter shaft, there being a stress-transferring relationship between the exterior of the stylet and the substance defining the shaft at least in the vicinity of the exit port, the stylet with the embedded relationship increasing the columnar strength of the shaft in the region of the port and increasing the pushability of the catheter.

Abstract: This invention provides prosthesis delivery systems with atraumatic tips that can be dislodged from the catheter so that the catheter can be easily removed from the body after expanding the prosthesis, by pulling the catheter proximally. With the tip dislodged, the catheter, which is of smaller diameter than the tip can be removed even in instances where the prosthesis does not expand the lumen to a large diameter. This invention also provides prosthesis delivery systems with a contoured protective outer sheath having smaller diameters in proximal portions that normally are acutely bent when the system is in the body, than in distal portions corresponding to the position of the prostheses. These systems are more flexible and the sheaths less likely to kink, especially when configured as part of a large delivery system.

Abstract: A device for percutaneous administration of fluid preparations into a body cavity, vessel or organ, the device including a tube having both a fluid lumen and an inflation lumen and defined by a proximal end lying outside of the body and a distal end lying within the body, the proximal end of the fluid lumen being in fluid communication with a fluid source and the distal end disposed within the body, the distal end of the inflation lumen in communication with an inflatable member disposed within the body. In one embodiment, one end of the tube is connected to a retention platform having a central portion with a recess to confront the patient's abdominal wall. The retention platform has a plurality of circumferentially-spaced fingers extending radially from said central portion where only the end portion of each finger rests on the abdominal wall of the patient. Preferably, the proximal end of the inflation lumen is remote from the fluid lumen.

Abstract: The present invention relates generally to a device for securing a tube, such as a medical catheter or feeding tube, at the site of a body opening. More specifically, the invention is directed to a bumper retention device for retaining a feeding tube in an angular fixation externally against the skin of a patient, so as to prevent slippage, dislodgement, or unnecessary migration of the feeding tube into the stomach, small intestine or other internal body cavity of a patient. The bumper retention device may be used with a conventional catheter or feeding tube and a conventional retention bar. The bumper retention unit comprises a retention stem portion connected to a loop portion. The loop portion is placed around the outer diameter of the feeding tube and when the tube is bent, the stem portion is inserted into an end aperture of the retention bar so that the tube is retained at an approximately 90.degree. angle.

Abstract: The present invention is directed to a pre-formed retention member having an improved construction and used for anchoring or retaining a catheter within a body cavity, organ or vessel. The pre-formed retention retains a distal open end of a single body access tube against an inner body cavity wall of a patient. The pre-formed member is secured to only the inner and outer peripheral edges of the distal open end of the tube by a sleeve. The sleeve has both an outer sleeve surface and an inner sleeve surface which receives, respectively, the outer and inner surfaces of the tube. The pre-formed member includes an outer surface and an inner surface which defines a retention chamber. The retention chamber extends beyond the distal open end of the tube so that no portion of the tube passes through the chamber.

Abstract: A tubular prosthesis including a tubular wall portion of loosely interlocked pattern, e.g. of knitted loops, constructed to function within a body lumen. The loops are preferably formed of co-knitted strand materials. A first strand material is a metal strand that structurally defines the tubular shape of the prosthesis and maintains the shape when positioned in the lumen. A second strand material is a predetermined substance selected to provide desired characteristics to the wall of the prosthesis.

Abstract: An apparatus for the in situ generation of an electrical current in a biological environment characterized by including an electrolytic fluid. The apparatus comprises first and second electrodes of differing electrochemical potentials separated by an insulator. The apparatus is adapted to be implanted in the environment. The presence of the electrolytic fluid and formation of a current path by hyperplastic cells bridging the electrodes enables electrolysis to occur and a direct current to pass through the current path to impede hyperplastic cell growth.