Patents by Inventor Erik Arstad
Erik Arstad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10118892Abstract: The present invention relates to sulfonium salts of formula (I): (I), their preparation, and utility as precursors for preparing functionalized organic compounds, wherein R1 and R2 are the same or different and each is independently selected from an optionally substituted aryl group, an optionally substituted alkynyl group, an optionally substituted alkenyl group, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted cycloalkenyl group, an optionally substituted aralkyl group, an optionally substituted arylalkenyl group, an optionally substituted heteroaryl group, an optionally substituted heterocyclyl group, an optionally substituted amine, an optionally substituted alkoxy group, an optionally substituted thioether group, an optionally substituted phosphine group, an optionally substituted boron species, an optionally substituted carbene, an organometallic moiety, and a halide, or R1 and R2 are joined together to form an optionally substituted sulfur-conType: GrantFiled: October 14, 2013Date of Patent: November 6, 2018Assignee: UCL BUSINESS PLCInventors: Erik Arstad, Kerstin Sander, Thibault Gendron
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Publication number: 20150266818Abstract: The present invention relates to sulfonium salts of formula (I): (I), their preparation, and utility as precursors for preparing functionalised organic compounds, wherein R1 and R2 are the same or different and each is independently selected from an optionally substituted aryl group, an optionally substituted alkynyl group, an optionally substituted alkenyl group, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted cycloalkenyl group, an optionally substituted aralkyl group, an optionally substituted arylalkenyl group, an optionally substituted heteroaryl group, an optionally substituted heterocyclyl group, an optionally substituted amine, an optionally substituted alkoxy group, an optionally substituted thioether group, an optionally substituted phosphine group, an optionally substituted boron species, an optionally substituted carbene, an organometallic moiety, and a halide, or R1 and R2 are joined together to form an optionally substituted sulfur-conType: ApplicationFiled: October 14, 2013Publication date: September 24, 2015Applicant: UCL BUSINESS PLCInventors: Erik Arstad, Kerstin Sander, Thibault Gendron
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Patent number: 8961930Abstract: Isatin 5-sulfonamide derivatives, pharmaceutical compositions comprising the derivatives, their use as molecular imaging agents, their use for the diagnosis or treatment of diseases or disorders associated with dysregulation of apoptosis, methods for synthesizing the derivatives, methods for the molecular imaging of caspase activity and apoptosis, and methods of assessing the therapeutic effect of a test substance on caspase activity are disclosed.Type: GrantFiled: September 4, 2009Date of Patent: February 24, 2015Assignees: Imperial Innovations Limited, Hammersmith Imanet LimitedInventors: Eric Ofori Aboagye, Graham Smith, Quang-De Nguyen, Erik Arstad, Matthias Eberhard Glaser
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Patent number: 8795631Abstract: The present invention relates to 18F radio-chemistry and in particular to a method for synthesising radiofluorinated amides and amines. The method of the invention has particular application in the radiosynthesis of a variety of 18F-labelled positron emission tomography (PET) tracers.Type: GrantFiled: October 20, 2009Date of Patent: August 5, 2014Assignees: HammerSmith Imanet Limited, GE Healthcare LimitedInventors: Robert James Domett Nairne, Erik Arstad, Matthias Eberhard Glaser
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Publication number: 20140127130Abstract: The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.Type: ApplicationFiled: January 9, 2014Publication date: May 8, 2014Applicant: HAMMERSMITH IMANET LIMITEDInventors: ERIK ARSTAD, MATTHIAS EBERHARD GLASER
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Patent number: 8679455Abstract: The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods of making such radiodiagnostic and radiotherapeutic agents and the compounds used in such methods. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.Type: GrantFiled: June 13, 2011Date of Patent: March 25, 2014Assignee: Hammersmith Imanet LimitedInventors: Erik Arstad, Matthias Eberhard Glaser
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Patent number: 8629299Abstract: The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.Type: GrantFiled: May 20, 2013Date of Patent: January 14, 2014Assignee: Hammersmith Imanet LimitedInventors: Erik Arstad, Matthias Eberhard Glaser
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Patent number: 8614360Abstract: The invention relates to new processes for preparation of 18F-fluoroalkyl halides suitable for use in labelling of Positron Emission Tomography (PET) radiotracers. The process of preparation comprises the step of reacting a 18F-fluoroacylhalide with Wilkinson's catalyst.Type: GrantFiled: December 8, 2006Date of Patent: December 24, 2013Assignee: Hammersmith Imanet LimitedInventor: Erik Arstad
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Publication number: 20130259802Abstract: The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.Type: ApplicationFiled: May 20, 2013Publication date: October 3, 2013Applicant: HAMMERSMITH IMANET LIMITEDInventors: ERIK ARSTAD, MATTHIAS EBERHARD GLASER
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Publication number: 20130209361Abstract: The present invention relates to a new synthetic process in which an alkyne and an azide react to form a radioisotopic bioconjugate construct. The reaction is particularly useful for producing compounds for use in imaging and radiotherapy applications. The present invention also provides bioconjugate labels and further relates to the use of these compounds in diagnostic and therapeutic methods. In addition, the invention provides a related process for introducing a radioisotopic halogen atom into a terminal alkyne.Type: ApplicationFiled: August 12, 2011Publication date: August 15, 2013Applicant: UCL BUSINESS PLCInventors: Erik Arstad, Ran Yan
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Patent number: 8506932Abstract: The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided.Type: GrantFiled: November 20, 2006Date of Patent: August 13, 2013Assignee: Hammersmith Imanet LimitedInventors: Erik Arstad, Ian Wilson, Sajinder Kaur Luthra, Frank Brady, Bengt Langstrom, Farhad Karimi, Edward George Robins, Bo Shan
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Patent number: 8496887Abstract: The invention relates to methods and apparatus for drying [18F]fluoride which comprises (i) passing a [18F]fluoride solution comprising water, a solvent, [18F]fluoride, and a cationic counterion through a narrow bore vessel at elevated temperature such that the water and solvent are vaporised forming a vaporised component, and (ii) collecting the resulting vaporised component by condensing into a collection vessel.Type: GrantFiled: March 26, 2012Date of Patent: July 30, 2013Assignee: Hammersmith Imanet LimitedInventor: Erik Arstad
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Patent number: 8445721Abstract: The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in particular 18F-labelled prosthetic groups for use in the preparation as well as non-labelled intermediates useful in the preparation of the [18F]-labelled prosthetic groups. [18F]-labelled compounds useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET) are also provided.Type: GrantFiled: March 8, 2012Date of Patent: May 21, 2013Assignee: Hammersmith Imanet LimitedInventors: Erik Arstad, Matthias Eberhard Glaser
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Patent number: 8409547Abstract: The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I) with a compound of formula (II): R*-L2-C?N+—O???(II) or, a compound of formula (III) with a compound of formula (IV) in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.Type: GrantFiled: June 25, 2012Date of Patent: April 2, 2013Assignee: Hammersmith Imanet LimitedInventors: Matthias Eberhard Glaser, Erik Arstad
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Patent number: 8309054Abstract: The invention relates to methods and apparatus for purifying a radiolabelled compound. The method comprises (i) passing a crude reaction mixture comprising the desired radiolabelled compound and one or more contaminants in a solvent through a narrow bore vessel at elevated temperature such that the organic solvent and either the radiolabelled compound or one or more contaminants is vaporised forming a vaporised component, and (ii) collecting the resulting vaporised component by condensing into a collection vessel.Type: GrantFiled: July 25, 2007Date of Patent: November 13, 2012Assignee: Hammersmith Imanet LimitedInventor: Erik Arstad
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Patent number: 8309055Abstract: The invention relates to novel 18F-labelled compounds which may be suitable for use as Positron Emission Tomography (PET) radiotracers, and to processes for preparation of such. The 18F-labelled compounds of the invention comprise a [18F]fluoroalkenyl group.Type: GrantFiled: January 27, 2012Date of Patent: November 13, 2012Assignee: Hammersmith Imanet LimitedInventors: Erik Arstad, Edward George Robins
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Publication number: 20120282171Abstract: The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction of a compound of formula (I) with a compound of formula (II): R*-L2-C?N+—O???(II) or, a compound of formula (III) with a compound of formula (IV) in the presence of a Cu (I) catalyst. The resultant labelled conjugates are useful as diagnostic agents, for example, as radiopharmaceuticals more specifically for use in Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) or for radiotherapy.Type: ApplicationFiled: June 25, 2012Publication date: November 8, 2012Applicant: HAMMERSMITH IMANET LIMITEDInventors: MATTHIAS EBERHARD GLASER, ERIK ARSTAD
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Publication number: 20120275973Abstract: The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group.Type: ApplicationFiled: July 12, 2012Publication date: November 1, 2012Applicants: HAMMERSMITH IMANET LIMITED, GE HEALTHCARE AS, GE HEALTHCARE LIMITEDInventors: SAJINDER KAUR LUTHRA, FRANK BRADY, NICHOLAS TOBY JEFFERY, ERIK ARSTAD, ALEXANDER MARK GIBSON, DUNCAN WYNN, ALAN CUTHBERTSON, MAGNE SOLBAKKEN
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Publication number: 20120186969Abstract: The invention relates to methods and apparatus for drying [18F]fluoride which comprises (i) passing a [18F]fluoride solution comprising water, a solvent, [18F]fluoride, and a cationic counterion through a narrow bore vessel at elevated temperature such that the water and solvent are vaporised forming a vaporised component, and (ii) collecting the resulting vaporised component by condensing into a collection vessel.Type: ApplicationFiled: March 26, 2012Publication date: July 26, 2012Applicant: HAMMERSMITH IMANET LIMITEDInventor: ERIK ARSTAD
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Patent number: 8221720Abstract: The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group.Type: GrantFiled: May 11, 2005Date of Patent: July 17, 2012Assignees: Hammersmith Imanet Limited, GE Healthcare Limited, GE Healthcare ASInventors: Sajinder Kaur Luthra, Frank Brady, Nicholas Toby Jeffery, Erik Arstad, Alexander Mark Gibson, Duncan Wynn, Alan Cuthbertson, Magne Solbakken