Patents by Inventor Erik Bjerregaard Pedersen

Erik Bjerregaard Pedersen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable and selective formation of hoogsteen-type triplexes and duplexes using twisted intercalating nucleic acids (TINA) and process for the preparation of TINA
    Patent number: 9102937
    Abstract: The present invention describes a flexible basestacking monomer that can be incorporated into an oligonucleotide or oligonucleotide analogue, as well as triplex forming oligonucleotides comprising the flexible basestacking monomer. Triplex forming oligonucleotides of the invention are capable of binding sequence specifically to doublestranded target nucleic acids and are therefore of interest for modulation of the activity of target nucleic acids and also detection of target nucleic acids.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: August 11, 2015
    Assignee: Tina Holding APS
    Inventors: Vyachelsav V. Filichev, Erik Bjerregaard Pedersen
  • INTERCALATING TRIPLEXES AND DUPLEXES USING ARYL NAPHTHOIMIDAZOL AND PROCESS FOR THE PREPARATION THEREOF
    Publication number: 20110130557
    Abstract: There is provided an intercalating oligonucleotide for stabilizing natural or modified DNA and RNA triplexes, duplexes and hybrids thereof having the general structure (I) triplex forming oligonucleotides of the invention are capable of binding specifically to double stranded target nucleic acids and are therefore of interest for modulation of the activity of target nucleic acids and also detection of target nucleic acids.
    Type: Application
    Filed: May 6, 2009
    Publication date: June 2, 2011
    Inventors: Erik Bjerregaard Pedersen, Amany Mostafa Ahmed Osman, Per Trolle Jorgensen, Niels Bomholt
  • PSEUDONUCLEOTIDE COMPRISING AN INTERCALATOR
    Publication number: 20100121056
    Abstract: The present invention relates to intercalator pseudonucleotides. Intercalator pseudonucleotides according to the invention are capable of being incorporated into the backbone of a nucleic acid or nucleic acid analogue and they comprise an intercalator comprising a flat conjugated system capable of co-stacking with nucleobases of DNA. The invention also relates to oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudo nucleotide. The invention furthermore relates to methods of synthesising intercalator pseudo nucleotides and methods of synthesising oligonucleotides or oligonucleotide analogues comprising at least one intercalator pseudonucleotide.
    Type: Application
    Filed: August 3, 2009
    Publication date: May 13, 2010
    Applicant: Human Genetic Signatures Pty. Ltd.
    Inventors: Ulf Bech Christensen, Erik Bjerregaard Pedersen
  • STABLE AND SELECTIVE FORMATION OF HOOGSTEEN-TYPE TRIPLEXES AND DUPLEXES USING TWISTED INTERCALATING NUCLEIC ACIDS (TINA) AND PROCESS FOR THE PREPARATION OF TINA
    Publication number: 20090216003
    Abstract: The present invention describes a flexible basestacking monomer that can be incorporated into an oligonucleotide or oligonucleotide analogue, as well as triplex forming oligonucleotides comprising the flexible basestacking monomer. Triplex forming oligonucleotides of the invention are capable of binding sequence specifically to doublestranded target nucleic acids and are therefore of interest for modulation of the activity of target nucleic acids and also detection of target nucleic acids.
    Type: Application
    Filed: May 24, 2006
    Publication date: August 27, 2009
    Inventors: Vyachelsav V Filichev, Erik Bjerregaard Pedersen