Abstract: This disclosure relates to libraries of multi-cytokine binding particles or other surfaces and uses in method for screening immune cells for improved immune modulating functionality. In certain embodiments, the libraries are used to identify desirable particles for stimulating immune cells useful for cancer and other immune cell therapies.

Abstract: The various embodiments of the present disclosure relate generally to compositions and methods for the targeted cellular delivery of nanoparticles. More particularly, the various embodiments of the present invention are directed to the cellular delivery of nanoparticles tethered to a ligand by way of a poly(ethylene glycol) linkage, wherein the ligand demonstrates a binding specificity for a cellular target. In an exemplary embodiment, the ligand is tamoxifen and the cellular target is the estrogen receptor, which is upregulated in many breast cancer cells.