Patents by Inventor Erik Cornelis Splinter

Erik Cornelis Splinter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STRUCTURAL VARIATION DETECTION IN CHROMOSOMAL PROXIMITY EXPERIMENTS
    Publication number: 20230170042
    Abstract: The present invention relates to the field of molecular biology and more in particular to DNA technology. The invention relates to strategies for assessing structural integrity of DNA sequences of a genomic region of interest, which has clinical applications in diagnostics and personalized cancer therapy. In particular, the invention provides a method of detecting a chromosomal rearrangement involving a genomic region of interest.
    Type: Application
    Filed: April 23, 2021
    Publication date: June 1, 2023
    Inventors: Wouter Leonard De Laat, Amin Allahyar, Erik Cornelis Splinter
  • SEQUENCING STRATEGIES FOR GENOMIC REGIONS OF INTEREST
    Publication number: 20160040228
    Abstract: The disclosure relates to methods for determining the sequence of a genomic region of interest comprising a target nucleotide sequence comprising: providing a DNA comprising a genomic region of interest, fragmenting the DNA, separating the DNA fragments, fragmenting and ligating the DNA fragments to provide for ligated fragments of the DNA fragments (or ligated DNA subfragments), and determining at least part of the sequences of at least part of the ligated DNA subfragments that comprise the target nucleotide sequence.
    Type: Application
    Filed: August 18, 2015
    Publication date: February 11, 2016
    Inventors: Elzo De Wit, Erik Cornelis Splinter