Patents by Inventor Erik Daa FUNDER

Erik Daa FUNDER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220194972
    Abstract: The present invention relates to a novel process for preparing a compound of formula (III) and rhenium chelated MAG3 oligonucleotides.
    Type: Application
    Filed: April 28, 2020
    Publication date: June 23, 2022
    Inventors: Dennis Jul Hansen, Erik Daa Funder, Joerg Hoernschemeyer
  • Patent number: 11267843
    Abstract: Stereodefined phosphorothioate oligonucleotides, related nucleoside monomers and methods of synthesis of both are described. The disclosed isobutyryl protected L-LNA-G monomers have following Formula 50 or 51 where R3 is independently CH2ODMTr or CH2OMMTr and R8, when present, is cyanoethyl. The monomers have improved solubility and stability characteristics, resulting in improved efficacy in oligonucleotide synthesis.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: March 8, 2022
    Assignee: Roche Innovation Center Copenhagen A/S
    Inventors: Nanna Albaek, Jacob Ravn, Erik Daa Funder
  • Patent number: 11261209
    Abstract: The present invention relates to the synthesis of stereo-defined phosphorothioate oligonucleotides of formula I: Wherein Z, R1, R5, R6 and R9 are as defined herein. Phosphorothioate oligonucleotides are useful as therapeutics.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: March 1, 2022
    Assignee: Roche Innovation Center Copenhagen A/S
    Inventors: Jacob Ravn, Erik Daa Funder
  • Publication number: 20210355150
    Abstract: The present invention relates to a method for preparing stereodefined phosphorothioate oligonucleotides, especially locked stereodefined phosphorothioate oligonucleotides with a high yield, using pyridinium acidic salts as a coupling activator.
    Type: Application
    Filed: April 27, 2021
    Publication date: November 18, 2021
    Inventors: Dennis Jul Hansen, Erik Daa Funder
  • Publication number: 20210179658
    Abstract: The present invention relates to the field of stereodefined phosphorothioate oligonucleotides and to stereodefining nucleoside monomers comprising an amine containing chiral auxiliary group, and methods of orthogonally protecting the nitrogen of chiral auxiliaries during oligonucleotide synthesis, preventing post elongation chain cleavage, increasing yield and purity of stereodefined phosphorothioate oligonucleotides.
    Type: Application
    Filed: March 20, 2018
    Publication date: June 17, 2021
    Inventors: Konrad Bleicher, Dennis Jul Hansen, Erik Daa Funder
  • Publication number: 20200385727
    Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.
    Type: Application
    Filed: June 5, 2020
    Publication date: December 10, 2020
    Inventors: Marianne Ravn Møller, Heidi Rye Hudlebusch, Lykke Pedersen, Erik Daa Funder, Christoffer Sondergaard, Jette Dam Hedegaard, Alexander Herbert Stephan
  • Publication number: 20200318103
    Abstract: The present invention relates to methods for identifying improved stereodefined phosphorothioate oligonucleotide variants of antisense oligonucleotides utilising sub-libraries of partially stereodefined oligonucleotides. The methods allow for the efficient identification of stereodefined variants with improved properties, such as enhanced in vitro or in vivo activity, enhanced efficacy, enhanced specific activity, reduced toxicity, altered biodistribution, enhanced cellular or tissue uptake, and/or enhanced target specificity (reduced off-target effects).
    Type: Application
    Filed: April 13, 2020
    Publication date: October 8, 2020
    Inventors: Konrad Bleicher, Henrik Frydenlund Hansen, Troels Koch, Nanna Albaek, Erik Daa Funder
  • Publication number: 20200291056
    Abstract: The present invention relates to the field of stereodefined phosphorothioate oligonucleotidess and to nucleoside monomers and methods of synthesis thereof. Herein are disclosed acyl protected L-LNA-G monomers which have improved solubility and stability characteristics, and result in improved efficacy in oligonucleotide synthesis.
    Type: Application
    Filed: March 2, 2017
    Publication date: September 17, 2020
    Inventors: Nanna Albaek, Jacob Ravn, Erik Daa Funder
  • Publication number: 20200148714
    Abstract: The present invention relates to the field of stereodefined phosphorothioate oligonucleotides and to stereodefining nucleoside monomers and methods of synthesis of stereodefined oligonucleotides using said monomer. Herein are disclosed oligonucleotide enhanced synthesis methods where within a single elongation cycle there are repeated coupling and oxidation steps.
    Type: Application
    Filed: June 26, 2018
    Publication date: May 14, 2020
    Inventors: Dennis Jul Hansen, Erik Daa Funder
  • Publication number: 20190153012
    Abstract: The present invention relates to the field of stereodefmed phosphorothioate oligonucleotides and to stereodefining nucleoside monomers and methods of synthesis of stereodefmed oligonucleotides. Herein are disclosed solvent compositions which provide enhanced solubility and stability of stereodefining nucleoside monomers, and can be used to improve the coupling efficacy of such monomers in oligonucleotide synthesis.
    Type: Application
    Filed: May 9, 2017
    Publication date: May 23, 2019
    Inventors: Jacob RAVN, Erik Daa FUNDER