Patents by Inventor Erik Evensen
Erik Evensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170299590Abstract: The invention provides methods and compositions for the diagnosis, prognosis, and/or treatment response characterization of individuals suffering from systemic lupus erythematosus (SLE) using single cell network profiling.Type: ApplicationFiled: June 27, 2017Publication date: October 19, 2017Inventors: Rachael HAWTIN, Wouter KORVER, Erik EVENSEN
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Publication number: 20170292946Abstract: The invention provides methods, compositions, and systems for diagnosis, prognosis, evaluation of status, and/or determination of treatment for pathological conditions.Type: ApplicationFiled: December 15, 2016Publication date: October 12, 2017Inventors: Jason PTACEK, Rachael HAWTIN, Erik EVENSEN
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Publication number: 20170285027Abstract: This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of a cell present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens.Type: ApplicationFiled: November 18, 2016Publication date: October 5, 2017Inventors: Wendy J. FANTL, Alessandra CESANO, Erik EVENSEN, Adam PALAZZO
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Publication number: 20170248604Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: ApplicationFiled: October 13, 2016Publication date: August 31, 2017Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
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Publication number: 20170184587Abstract: Methods and compositions are described for categorizing and treating autoimmune disease, using single cell network profiling (SCNP), where activation levels of one or more activatable elements are determined in single cells, with or without modulation, to categorize or determine treatment for the autoimmune disease.Type: ApplicationFiled: August 5, 2016Publication date: June 29, 2017Inventors: Jason Ptacek, Rachael Hawtin, Erik Evensen, James Cordeiro, Alessandra Cesano
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Patent number: 9500655Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: GrantFiled: May 16, 2014Date of Patent: November 22, 2016Assignee: NODALITY, INC.Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
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Publication number: 20160267113Abstract: In one embodiment, one or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to receive a set of parameter values defining a boundary within a data space associated with a dataset. The dataset can represent signaling related to a test substance. A first metric can be defined based on a first portion of the dataset associated with a first region defined by the boundary. A second metric can be defined based on a second portion of the dataset associated with a second region defined by the boundary after the boundary is modified. The second region can be different than the first region.Type: ApplicationFiled: October 14, 2015Publication date: September 15, 2016Applicant: Nodality, Inc.Inventors: Steven C. BANVILLE, Santosh Krishna PUTTA, David C. SPELLMEYER, Nikil WALE, Erik EVENSEN, Norman Baylis PURVIS, JR., Gregory Daniel FRIEDLAND
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Publication number: 20160245794Abstract: The invention provides methods and compositions for the diagnosis, prognosis, and/or treatment response characterization of individuals suffering from systemic lupus erythematosus (SLE) using single cell network profiling.Type: ApplicationFiled: August 27, 2015Publication date: August 25, 2016Inventors: Rachael Hawtin, Wouter Korver, Erik Evensen
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Patent number: 9183237Abstract: In one embodiment, one or more processor-readable media storing code representing instructions that when executed by one or more processors cause the one or more processors to receive a set of parameter values defining a boundary within a data space associated with a dataset. The dataset can represent signaling related to a test substance. A first metric can be defined based on a first portion of the dataset associated with a first region defined by the boundary. A second metric can be defined based on a second portion of the dataset associated with a second region defined by the boundary after the boundary is modified. The second region can be different than the first region.Type: GrantFiled: November 26, 2012Date of Patent: November 10, 2015Inventors: Steven C. Banville, Santosh K. Putta, David C. Spellmeyer, Nikil Wale, Erik Evensen, Norman Purvis, Greg Friedland
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Publication number: 20150241427Abstract: This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of a cell present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g.Type: ApplicationFiled: December 17, 2014Publication date: August 27, 2015Inventors: Wendy J. FANTL, Alessandra CESANO, Erik EVENSEN, Adam PALAZZO
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Publication number: 20150017119Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: ApplicationFiled: May 16, 2014Publication date: January 15, 2015Applicant: Nodality, Inc.Inventors: Wendy J. FANTL, David B. ROSEN, Alessandra CESANO, Santosh K. PUTTA, Garry NOLAN, Aileen COHEN, Erik EVENSEN
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Publication number: 20140255393Abstract: Methods and compositions are described for categorizing and treating autoimmune disease, using single cell network profiling (SCNP), where activation levels of one or more activatable elements are determined in single cells, with or without modulation, to categorize or determine treatment for the autoimmune disease.Type: ApplicationFiled: February 28, 2014Publication date: September 11, 2014Applicant: Nodality, Inc.Inventors: Jason Ptacek, Rachael Hawtin, Erik Evensen, James Cordeiro, Alessandra Cesano
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Patent number: 8778620Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: GrantFiled: May 17, 2012Date of Patent: July 15, 2014Assignee: Nodality, Inc.Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
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Publication number: 20140093903Abstract: The invention provides methods, compositions, and systems for diagnosis, prognosis, evaluation of status, and/or determination of treatment for pathological conditions.Type: ApplicationFiled: August 27, 2013Publication date: April 3, 2014Applicant: Nodality, Inc.Inventors: Jason Ptacek, Racheal Hawtin, Erik Evensen
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Publication number: 20130130279Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: ApplicationFiled: May 17, 2012Publication date: May 23, 2013Applicant: Nodality, Inc.Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
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Patent number: 8227202Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: GrantFiled: July 10, 2009Date of Patent: July 24, 2012Assignee: Nodality, Inc.Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen
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Publication number: 20100297676Abstract: This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of a cell present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens.Type: ApplicationFiled: May 20, 2010Publication date: November 25, 2010Applicant: Nodality, Inc.Inventors: Wendy J. Fantl, Alessandra Cesano, Erik Evensen, Adam Palazzo
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Publication number: 20100030719Abstract: In one embodiment, one or more processor-readable media can be configured to store code representing instructions that when executed by one or more processors can cause the one or more processors to select a first relationship rule based on a first combination of parameters including a first parameter, and based on a hierarchical position of the first parameter within a hierarchical structure of a set of parameters from a biological category. A first statistical value can be defined based on a plurality of test values and based on the first relationship rule. A second statistical value can be defined based on a second relationship rule and based on a second combination of parameters. The second relationship rule can be selected based on a hierarchical position of the second parameter within the hierarchical structure of the set of parameters.Type: ApplicationFiled: August 10, 2009Publication date: February 4, 2010Inventors: Todd M. Covey, Erik Evensen, Santosh K. Putta
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Publication number: 20100009364Abstract: The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.Type: ApplicationFiled: July 10, 2009Publication date: January 14, 2010Applicant: Nodality, Inc.Inventors: Wendy J. Fantl, David B. Rosen, Alessandra Cesano, Santosh K. Putta, Garry Nolan, Aileen Cohen, Erik Evensen