Patents by Inventor Erik Hellstrom
Erik Hellstrom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200325215Abstract: The invention includes the use of the HE/HE4a markers to assess ovarian cancer in a subject. Included also are compositions and methods of using HE/HE4a marker for diagnosis, grading and staging of ovarian cancers, determining prognosis and treatment effectiveness of a subject who has been diagnosed with ovarian cancer.Type: ApplicationFiled: July 1, 2020Publication date: October 15, 2020Applicants: PACIFIC NORTHWEST DIABETES RESEARCH INSTITUTE, FUJIREBIO DIAGNOSTICS, INC.Inventors: Ingegerd HELLSTROM, Karl-Erik HELLSTROM, John RAYCRAFT, Christian FERMÉR, Eva RÖIJER
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Patent number: 10202927Abstract: Methods and systems for controlling combustion performance of an engine during recompression HCCI combustion are provided. The method includes regulating a valve actuation timing and a fuel injection timing to cause a combustion phasing of at least one cylinder of the engine to approach a target combustion phasing, and estimating current combustion state information based on the combustion phasing. The current combustion state information includes at least one of a temperature, a pressure, and a pre-combustion charge composition associated with the at least one cylinder. The method further includes determining a target fuel injection amount, and determining whether the target fuel injection amount would require actuator settings that violate predetermined constraints in order to cause the combustion phasing to approach the target combustion phasing. A fuel injection amount is adjusted when the target fuel injection amount would require actuator settings that violate the predetermined constraints.Type: GrantFiled: September 17, 2012Date of Patent: February 12, 2019Assignees: Robert Bosch GmbH, The Regents of the University of MichiganInventors: Shyam Jade, Erik Hellstrom, Anna Stefanopoulou, Li Jiang
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Publication number: 20180217158Abstract: The present invention features, inter alia, compositions and methods related to the detection of HE4-expressing tumor cells in a subject. The methods include detection of anti-HE4 antibodies in a biological sample obtained from the subject. The methods are useful for diagnosis and monitoring the efficacy of treatments for cancers in which HE4 is expressed, for example, ovarian cancer.Type: ApplicationFiled: January 25, 2018Publication date: August 2, 2018Applicant: University of Washington through its Center for CommercializationInventors: Karl Erik Hellstrom, Ingegerd Hellstrom, Pu Liu, Jade Jaffar, Elizabeth Swisher
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Publication number: 20180057575Abstract: The invention includes the use of the HE/HE4a markers to assess ovarian cancer in a subject. Included also are compositions and methods of using HE/HE4a marker for diagnosis, grading and staging of ovarian cancers, determining prognosis and treatment effectiveness of a subject who has been diagnosed with ovarian cancer.Type: ApplicationFiled: October 19, 2017Publication date: March 1, 2018Applicants: PACIFIC NORTHWEST DIABETES RESEARCH INSTITUTE, FUJIREBIO DIAGNOSTICS, INC.Inventors: Ingegerd HELLSTROM, Karl-Erik HELLSTROM, John RAYCRAFT, Christian FERMÉR, Eva RÖIJER
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Patent number: 9822169Abstract: The invention includes the use of the HE/HE4a markers to assess ovarian cancer in a subject. Included also are compositions and methods of using HE/HE4a marker for diagnosis, grading and staging of ovarian cancers, determining prognosis and treatment effectiveness of a subject who has been diagnosed with ovarian cancer.Type: GrantFiled: February 17, 2011Date of Patent: November 21, 2017Assignees: PACIFIC NORTHWEST DIABETES RESEARCH INSTITUTE, FUJIREBIO DIAGNOSTICS, INC.Inventors: Ingegerd Hellstrom, Karl-Erik Hellstrom, John Raycraft, Christian Fermér, Eva Roijer
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Patent number: 9708991Abstract: Systems and methods are described for on-line, real-time estimation of a residual mass in an engine cylinder during HCCI combustion. The residual mass is estimated based on an estimated residual mass for a previous combustion cycle. A value of a first performance variable for the first combustion cycle is determined based only on engine data measured by one or more sensors. A value of a second performance is estimated based at least in part on the estimated residual mass for the first combustion cycle. An adaptive scaling factor is determining for the first combustion cycle based on the determined value of the first performance variable and the estimated value of the second performance variable. An adjusted residual mass for the first combustion cycle is then determined based on the estimated residual mass for the first combustion cycle and the adaptive scaling factor for the first combustion cycle.Type: GrantFiled: February 20, 2014Date of Patent: July 18, 2017Assignees: Robert Bosch GmbH, The Regents of the University of MichiganInventors: Jacob Larimore, Li Jiang, Erik Hellstrom, Shyam Jade, Anna Stefanopoulou, Julien Vanier
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Patent number: 9429096Abstract: Methods and systems are provided for controlling a vehicle engine to reduce cycle-to-cycle combustion variation. A predictive model is applied to predict cycle-to-cycle combustion behavior of an engine based on observed engine performance variables. Conditions are identified, based on the predicted cycle-to-cycle combustion behavior, that indicate high cycle-to-cycle combustion variation. Corrective measures are then applied to prevent the predicted high cycle-to-cycle combustion variation.Type: GrantFiled: September 17, 2012Date of Patent: August 30, 2016Assignees: Robert Bosch GmbH, The Regents of the University of WisconsinInventors: Erik Hellstrom, Anna Stefanopoulou, Li Jiang, Jacob Larimore
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Patent number: 9376979Abstract: Methods and systems for controlling combustion performance of an engine are provided. A desired fuel quantity for a first combustion cycle is determined. One or more engine actuator settings are identified that would be required during a subsequent combustion cycle to cause the engine to approach a target combustion phasing. If the identified actuator settings are within a defined acceptable operating range, the desired fuel quantity is injected during the first combustion cycle. If not, an attenuated fuel quantity is determined and the attenuated fuel quantity is injected during the first combustion cycle.Type: GrantFiled: September 17, 2012Date of Patent: June 28, 2016Assignees: Robert Bosch GmbH, The Regents of the University of MichiganInventors: Shyam Jade, Erik Hellstrom, Anna Stefanopoulou, Li Jiang
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Patent number: 9334818Abstract: Methods and systems are described for controlling engine combustion during a mixed-mode combustion modality. A target exhaust valve timing is determined based on a first combination of engine speed and load. An amount of trapped residual in an engine cylinder after an exhaust valve is closed during a first combustion cycle is also determined. Based at least in part on the amount of trapped residual, an amount of gas that will be drawn into the engine cylinder when the intake valve is opened during a second combustion cycle is determined. The target exhaust valve timing is then adjusted during the second combustion cycle in order to adjust the amount of gas that will be drawn into the engine cylinder when the intake valve is opened during a third combustion cycle.Type: GrantFiled: March 21, 2014Date of Patent: May 10, 2016Assignee: Robert Bosch GmbHInventors: Jason Schwanke, Anna Stefanopoulou, Li Jiang, Jeffrey S. Sterniak, Nikhil Ravi, Joel Oudart, Erik Hellstrom
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Patent number: 9228527Abstract: Methods and systems are provided for estimating engine performance information for a combustion cycle of an internal combustion engine. Estimated performance information for a previous combustion cycle is retrieved from memory. The estimated performance information includes an estimated value of at least one engine performance variable. Actuator settings applied to engine actuators are also received. The performance information for the current combustion cycle is then estimated based, at least in part, on the estimated performance information for the previous combustion cycle and the actuator settings applied during the previous combustion cycle. The estimated performance information for the current combustion cycle is then stored to the memory to be used in estimating performance information for a subsequent combustion cycle.Type: GrantFiled: September 17, 2012Date of Patent: January 5, 2016Inventors: Erik Hellstrom, Anna Stefanopoulou, Li Jiang, Jacob Larimore
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Publication number: 20150353629Abstract: The invention includes the use of the HE/HE4a markers to assess ovarian cancer in a subject. Included also are compositions and methods of using HE/HE4a marker for diagnosis, grading and staging of ovarian cancers, determining prognosis and treatment effectiveness of a subject who has been diagnosed with ovarian cancer.Type: ApplicationFiled: February 17, 2011Publication date: December 10, 2015Inventors: Ingegerd Hellstrom, Karl-Erik Hellstrom, John Raycraft, Christian Fermér, Eva Röijer
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Publication number: 20140283800Abstract: Methods and systems are described for controlling engine combustion during a mixed-mode combustion modality. A target exhaust valve timing is determined based on a first combination of engine speed and load. An amount of trapped residual in an engine cylinder after an exhaust valve is closed during a first combustion cycle is also determined. Based at least in part on the amount of trapped residual, an amount of gas that will be drawn into the engine cylinder when the intake valve is opened during a second combustion cycle is determined. The target exhaust valve timing is then adjusted during the second combustion cycle in order to adjust the amount of gas that will be drawn into the engine cylinder when the intake valve is opened during a third combustion cycle.Type: ApplicationFiled: March 21, 2014Publication date: September 25, 2014Applicant: Robert Bosch GmbHInventors: Erik Hellstrom, Anna Stefanopoulou, Li Jiang, Jeffrey S. Sterniak, Nikhil Ravi, Joel Oudart, Jason Schwanke
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Publication number: 20140230780Abstract: Systems and methods are described for on-line, real-time estimation of a residual mass in an engine cylinder during HCCI combustion. The residual mass is estimated based on an estimated residual mass for a previous combustion cycle. A value of a first performance variable for the first combustion cycle is determined based only on engine data measured by one or more sensors. A value of a second performance is estimated based at least in part on the estimated residual mass for the first combustion cycle. An adaptive scaling factor is determining for the first combustion cycle based on the determined value of the first performance variable and the estimated value of the second performance variable. An adjusted residual mass for the first combustion cycle is then determined based on the estimated residual mass for the first combustion cycle and the adaptive scaling factor for the first combustion cycle.Type: ApplicationFiled: February 20, 2014Publication date: August 21, 2014Applicant: Robert Bosch GmbHInventors: Jacob Larimore, Li Jiang, Erik Hellstrom, Shyam Jade, Anna Stefanopoulou, Julien Vanier
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Publication number: 20130224772Abstract: The present invention features, inter alia, compositions and methods related to the detection of HE4-expressing tumor cells in a subject. The methods include detection of anti-HE4 antibodies in a biological sample obtained from the subject. The methods are useful for diagnosis and monitoring the efficacy of treatments for cancers in which HE4 is expressed, for example, ovarian cancer.Type: ApplicationFiled: August 26, 2011Publication date: August 29, 2013Applicant: University of Washington through its Center for CommercializationInventors: Karl Erik Hellstrom, Ingegerd Hellstrom, Pu Liu, Jade Jaffar, Elizabeth Swisher
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Publication number: 20130090837Abstract: Methods and systems for controlling combustion performance of an engine are provided. A desired fuel quantity for a first combustion cycle is determined. One or more engine actuator settings are identified that would be required during a subsequent combustion cycle to cause the engine to approach a target combustion phasing. If the identified actuator settings are within a defined acceptable operating range, the desired fuel quantity is injected during the first combustion cycle. If not, an attenuated fuel quantity is determined and the attenuated fuel quantity is injected during the first combustion cycle.Type: ApplicationFiled: September 17, 2012Publication date: April 11, 2013Applicant: ROBERT BOSCH GMBHInventors: Shyam Jade, Erik Hellstrom, Anna Stefanopoulou, Li Jiang
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Publication number: 20110300186Abstract: Compositions containing an optionally surface-functionalized mesoporous support and a biologically active agent, and pharmaceutical compositions of the same, are provided herein. Such compositions can be useful in the treatment of tumors, for example, by injection of the composition at a location near the site of the tumor.Type: ApplicationFiled: April 14, 2011Publication date: December 8, 2011Applicants: Battelle Memorial Institute, University of Washington through its Center for CommercializationInventors: Karl Erik Hellstrom, Ingegerd Hellstrom, Pu Liu, Huafeng Wei, Jun Liu, Chenghong Lei, Baowei Chen, Xiaolin Li
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Publication number: 20110104675Abstract: The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble forms of mesothelin polypeptides, including mesothelin related antigen (MRA). In particular the invention provides a nucleic acid sequence encoding MRA and an MRA variant. The invention also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a mesothelin polypeptide with a molecule naturally occurring in soluble form in a sample from such a subject, and by hybridization screening using an MRA nucleotide sequence, as well as other related advantages.Type: ApplicationFiled: May 17, 2010Publication date: May 5, 2011Applicant: Pacific Northwest Research InstituteInventors: Nathalie Scholler, Ingegerd Hellstrom, Karl Erik Hellstrom
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Patent number: 7745159Abstract: The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble forms of mesothelin polypeptides, including mesothelin related antigen (MRA). In particular the invention provides a nucleic acid sequence encoding MRA and an MRA variant. The invention also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a mesothelin polypeptide with a molecule naturally occurring in soluble form in a sample from such a subject, and by hybridization screening using an MRA nucleotide sequence, as well as other related advantages.Type: GrantFiled: February 13, 2004Date of Patent: June 29, 2010Inventors: Nathalie B Scholler, Ingegerd Hellstrom, Karl Erik Hellstrom
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Patent number: 7547681Abstract: The invention provides compositions and methods directed to cell surface receptor antigen specific vaccines. More specifically, vaccines are provided that induce or enhance host antibody titers specific for cell surface receptor antigens and that include recombinant expression constructs containing nucleic acids encoding a target cell surface receptor antigen and one or more immune response altering molecules, or the expressed products themselves.Type: GrantFiled: January 20, 2004Date of Patent: June 16, 2009Assignee: University of WashingtonInventors: Nathalie B Scholler, Mary L Disis, Ingegerd Hellstrom, Karl Erik Hellstrom
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Publication number: 20090104684Abstract: The invention is directed to compositions and methods for the detection of a malignant condition, and relates to the discovery of soluble and cell surface forms of HE4a polypeptides, including HE4a that is overexpressed in ovarian carcinomas. In particular the invention provides a nucleic acid sequence encoding HE4a, and also provides a method of screening for the presence of a malignant condition in a subject by detecting reactivity of an antibody specific for a HE4a polypeptide with a molecule naturally occurring in soluble and/or cell surface form in a sample from such a subject, and by hybridization screening using an HE4a nucleotide sequence, as well as other related advantages.Type: ApplicationFiled: August 8, 2007Publication date: April 23, 2009Applicants: Pacific Northwest Research Institute, University of WashingtonInventors: Michel Schummer, INGEGERD HELLSTROM, Karl Erik Hellstrom, JEFFREY A. LEDBETTER, MARTHA HAYDEN-LEDBETTER