Patents by Inventor Erik Holm
Erik Holm has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5830352Abstract: A reagent delivery system comprises an axial hub passing through the center of two equal-diameter, spaced apart discs, wherein the hub and discs are positioned in a sleeve such that an annular reagent chamber is provided. When the sleeve is moved in either an up or down axial direction the so-formed chamber is opened and the reagent is released. Such a regent delivery system is particularly useful in a centrifuge for concentrating or preparing blood products.Type: GrantFiled: December 1, 1995Date of Patent: November 3, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5824230Abstract: A method and a device for separating a component, such as fibrin monomer from blood, by centrifugation, involve feeding of blood admixed an anticoagulant to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall. The top wall or the bottom wall is formed by a piston body displaceable within the first chamber. This method involves furthermore a centrifugation of the device about the said common axis to substantially separate blood into a cell fraction and a plasma fraction followed by the resulting plasma fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall. The outer cylindrical wall extends coaxially with the said common axis, whereby a fraction with fibrin I is caused to be separated in the second chamber while a suitable enzyme is being added.Type: GrantFiled: November 7, 1996Date of Patent: October 20, 1998Assignee: E.R. Squibb & Sons, Inc.Inventors: Niels Erik Holm, Peter A. D. Edwardson
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Patent number: 5795489Abstract: A method and a device for separating a component, such as fibrin I from blood, by centrifugation. The method involves feeding of blood admixed an anticlotter to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall, where the top wall or the bottom wall is formed by a piston body displaceable within the first chamber. The method involves furthermore a centrifugation of the device about the said common axis followed by a resulting liquid fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall, which extends coaxially with said common axis.Type: GrantFiled: November 8, 1996Date of Patent: August 18, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5792344Abstract: In a process of separating a liquid sample having phase portions of different densities by centrifugal separation, a phase separator container is employed. The phase separator container comprises a housing having concentric inner and outer cylindrical walls defining a longitudinal axis and a top wall and further a piston body constituting a bottom wall of the housing. The piston body defines together with the outer cylindrical wall, the inner cylindrical wall and the top wall, an annular chamber for receiving the liquid sample. The piston body is displaceable within the annular chamber for draining a phase portion separated from the liquid sample through a drain conduit means communicating with the annular chamber. The phase separation chamber further comprises a reaction chamber to which the phase portions exposed from the annular chamber is processed.Type: GrantFiled: October 31, 1996Date of Patent: August 11, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5776336Abstract: In a process of separating a liquid sample having phase portions of different densities by centrifugal separation, a phase separator container is employed. The phase separator container comprises a housing having concentric inner and outer cylindrical walls defining a longitudinal axis and a top wall and further a piston body constituting a bottom wall of the housing. The piston body defines together with the outer cylindrical wall, the inner cylindrical wall and the top wall, an annular chamber for receiving the liquid sample. The piston body is displaceable within the annular chamber for draining a phase portion separated from the liquid sample through a drain conduit means communicating with the annular chamber. The phase separation chamber further comprises a reaction chamber to which the phase portions exposed from the annular chamber is processed.Type: GrantFiled: October 31, 1996Date of Patent: July 7, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5746979Abstract: A method of separating fluid into two or more separable fractions. One container section (2) and the adjacent portion of the other container section are made of solid material, and the two container sections are screwed together. The container sections (1 and 2) have their respective chambers (29 and 30) for receiving their respective fluid ingredients, and these chambers are interconnected through a connecting channel (31) through the abutting portions, at which the container sections (1 and 2) are screwed together. A valve seat (21, 27) is shaped at each end of the connecting channel (31) for each valve member (22, 16) for a sealing closing of the chambers (29, 30) in the separated state of the container sections (1, 2).Type: GrantFiled: June 6, 1995Date of Patent: May 5, 1998Assignee: F. R, Squibb & Sons, Inc.Inventor: Niels Erik Holm
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Patent number: 5741428Abstract: In a process of separating a liquid sample having phase portions of different densities by centrifugal separation, a phase separator container is employed. The phase separator container comprises a housing having concentric inner and outer cylindrical walls defining a longitudinal axis and a top wall and further a piston body constituting a bottom wall of the housing. The piston body defines together with the outer cylindrical wall, the inner cylindrical wall and the top wall, an annular chamber for receiving the liquid sample. The piston body is displaceable within the annular chamber for draining a phase portion separated from the liquid sample through a drain conduit means communicating with the annular chamber. The phase separation chamber further comprises a reaction chamber to which the phase portions exposed from the annular chamber is processed.Type: GrantFiled: October 31, 1996Date of Patent: April 21, 1998Assignee: E.R. Squibb & Sons, Inc.Inventor: Niels Erik Holm
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Patent number: 5738784Abstract: A method and a device for separating a component, such as fibrin monomer from blood, by centrifugation, involve feeding of blood admixed an anticoagulant to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall. The top wall or the bottom wall is formed by a piston body displaceable within the first chamber. This method involves furthermore a centrifugation of the device about the said common axis to substantially separate blood into a cell fraction and a plasma fraction followed by the resulting plasma fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall. The outer cylindrical wall extends coaxially with the said common axis, whereby a fraction with fibrin I is caused to be separated in the second chamber while a suitable enzyme is being added.Type: GrantFiled: December 1, 1995Date of Patent: April 14, 1998Assignee: E.R. Squibb & Sons, Inc.Inventors: Niels Erik Holm, Peter A. D. Edwardson
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Patent number: 5733446Abstract: A method and a device for separating a component, such as fibrin I from blood, by centrifugation. The method involves feeding of blood admixed an anticlotter to a first annular chamber in a device, where the annular chamber is defined by a cylindrical outer wall and a cylindrical inner wall, both walls extending coaxially about a common axis, as well as by a top wall and a bottom wall, where the top wall or the bottom wall is formed by a piston body displaceable within the first chamber. The method involves furthermore a centrifugation of the device about the said common axis followed by a resulting liquid fraction being transferred while influenced by the piston body to a second chamber defined by an outer cylindrical wall, which extends coaxially with said common axis.Type: GrantFiled: December 2, 1994Date of Patent: March 31, 1998Assignee: Bristol-Myers Squibb CompanyInventor: Niels Erik Holm
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Patent number: 5674458Abstract: A container for receiving and separating blood plasma into its ingredients that has two sealingly coupled sections (1 and 2). One container section (2) and the adjacent portion of the other container section are made of solid material, and the two container sections are screwed together. The container sections (1 and 2) comprise their respective chambers (29 and 30) for receiving their respective fluid ingredients, and these chambers are interconnected through a connecting channel (31) through the abutting portions, at which the container sections (1 and 2) are screwed together. A valve seat (21, 27) is shaped at each end of the connecting channel (31) for each valve member (22, 16) for a sealing closing of the chambers (29, 30) in the separated state of the container sections (1, 2).Type: GrantFiled: June 6, 1995Date of Patent: October 7, 1997Assignee: E. R. Squibb & Sons, Inc.Inventor: Niels Erik Holm
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Patent number: 5658533Abstract: A container for receiving and separating blood plasma into its ingredients having two sealingly coupled sections (1 and 2). One container section (2) and the adjacent portion of the other container section are made of solid material, and the two container sections are screwed together. The container sections (1 and 2) have their respective chamber (29 and 30) for receiving their respective fluid ingredients, and these chambers are interconnected through a connecting channel (31) through the abutting portions, at which the container sections (1 and 2) are screwed together. A valve seat (21, 27) is shaped at each end of the connecting channel (31) for each valve member (22, 16) for a sealing closing of the chambers (29, 30) in the separated state of the container sections (1, 2).Type: GrantFiled: June 6, 1995Date of Patent: August 19, 1997Assignee: E.R. Squibb & Sons, Inc.Inventor: Niels Erik Holm
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Patent number: 5605541Abstract: A novel device and method for the application of two or more components of a fibrin sealant using a gas is disclosed. The novel device and method involve the concentric arrangement of annular apertures for each of the components concentric with and radially outward of a center gas discharge aperture in the exit end of a spray head. Reservoirs for each component, for example syringe cartridges or cylinders, are in dextrete fluid communication with the spray head and preferably can be activated by a common means.Type: GrantFiled: December 8, 1994Date of Patent: February 25, 1997Assignee: E. R. Squibb and Sons, Inc.Inventor: Niels-Erik Holm
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Patent number: 4338594Abstract: A monitoring system for shopping trolleys of the kind used in self-service stores, including a basket for the goods and having at least one support surface below the basket and which is not normally visible to the check-out operator and provides a transmitter/receiver to detect an article on such a lower support surface and a further transmitter/receiver disposed at a lower level, to block operation of the transmitter/receiver in response to the legs of the customer, parts of the trolley running gear and the like and a device to provide a signal in response to operation of the transmitter/receiver.Type: GrantFiled: November 14, 1980Date of Patent: July 6, 1982Inventor: Lars-Erik Holm