Abstract: The present invention relates to a cover (10) intended for a pool system (1), the cover being lightly flexible and formed as a pool-covering structure and serving as a protection, where said cover (10) is adapted to cooperate in edge-related fashion with a guide arrangement (11) or similar means, said cover (10) being oriented by support means (112) at a predetermined distance from the upper surface of a body of liquid or body of water enclosed by the pool. Said cover is integrally formed with and/or adapted to support liquid-Tillable or liquid-filled channels (14, 14a) where said channels are adapted to be included in one or more thermal energy absorbing units (6a) included in one or more suntrap apparatuses (6). A liquid in these liquid-filled channels (14), heated by solar energy, is adapted to be heat exchanged with said body of liquid or body of water (2) enclosed by the pool.

Abstract: The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using all of the foregoing.

Abstract: The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using all of the foregoing.

Abstract: The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using all of the foregoing.

Abstract: A trailer hitch for heavy vehicles has a coupling housing arranged on the traction vehicle with a rear, vertical end piece from which extends an upper, forward protruding coupling yoke piece and a lower, forward protruding coupling yoke piece, between which a tow eye on a trailer and a tow ball arranged in the tow eye are intended to be secured by means of a coupling pin running through a hole in the tow ball. A principally vertical wedge (12) is arranged between both coupling yoke pieces (3, 4) in front of the rear end piece (2) and is so designed that the wedging action increases, i.e. the force of the wedge increases, as the wedge is pressed down. An intermediate piece (14), equipped partly with an upper, forward protruding part (15) and partly a lower, forward protruding part (17), is arranged between the wedge (12) and the tow ball (6), whereby the parts are intended to abut against an upper (16) and a lower (18) part of the tow ball.

Abstract: A system and method for generating a mask layout file to eliminate antenna effects in an integrated circuit are disclosed. The method includes analyzing a pattern in a mask layout file to identify a region including an antenna ratio less than a first design rule. A feature located in the identified region is moved based on a second design rule from a first position to a second position in the mask layout file. A grounding feature is placed in the space and automatically connected to a gate feature in the mask layout file such that the antenna ratio is increased to greater than or approximately equal to the first design rule.

Abstract: The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using all of the foregoing.

Abstract: Substantially pure dimers of Apolipoprotein AI-Milano (APO-AI-M/APO AI-M) were isolated from plasma and characterized. Apolipoprotein AI-M dimer can also be produced in a recombinant Escherichia coli system. Pharmaceutical compositions comprising the ApoAI-AI-M/ApoAI-M are described. Patients with atherosclerosis or cardiovascular diseases can be treated with the dimer. Medicaments containing the dimer can also be used to prevent thrombosis in different clinical circumstances, both at the arterial and at the venous level. The dimer can also act as a prodrug for the monomer.

Abstract: The present invention concerns a trailer hitch for heavy vehicles, which exhibits a coupling housing arranged on the traction vehicle comprising a rear, vertical end piece from which extend's an upper, forward protruding coupling yoke piece and a lower, forward protruding coupling yoke piece, between which a low eye on a trailer and a low ball arranged in the tow eye are intended to be secured by means of a coupling pin running through a hole in the tow ball. In accordance with the invention, the trailer hitch is characterised by the following distinctive features: A principally vertical wedge (12) that is arranged between both coupling yoke pieces (3, 4) in front of the rear end piece (2) and is so designed that the wedging action increases, i.e.

Abstract: The present invention provides genes encoding novel matrix metalloproteinases termed MMP; constructs and recombinant host cells incorporating the genes; the MMP polypeptides encoded by the genes; antibodies to the MMP polypeptides; and methods of making and using all of the foregoing.

Abstract: The present invention is directed to crystals comprising at least part of the estrogen receptor &agr; (ER&agr;) ligand binding domain, optionally bound to a ligand. The present invention is also directed to ligands that bind to ER receptors, and method of designing them. The present invention is also directed to a homology model of the ER&bgr; receptor.

Abstract: Novel glucocorticoid and thyroid receptor ligands as provided which have the general formula (I): in which R1 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid or ester thereof, alkenyl carboxylic acid or ester thereof, hydroxy, halogen, or cyano, or a pharmaceutically acceptable salt thereof. R2 and R3 are the same or different, and are hydrogen, halogen, alkyl of 1 to 4 carbons, or cycloalkyl of 3 to 5 carbons, at least one of R2 and R3 being other than hydrogen. X is carbonyl or methylene. R4 is an aliphatic, aromatic or heteroaromatic. Y is hydroxyl, methoxy, amino, or alkyl amino. n is an integer from 0 to 4. A method for treating diseases associated with metabolism dysfunction or which are dependent on the expression of a glucocorticoid or thyroid receptor gene such as diabetes, hypercholesterolemia, or obesity using these compounds is also disclosed.

Abstract: Substantially pure dimers of Apolipoprotein Al-Milano (Al-M/APO Al-M) isolated and characterized from plasma are provided. Pharmaceutical compositions comprising the Apo Al-M/Apo Al-M are also provided. Apolipoprotein Al-M dimer can be produced in a recombinant Escherichia coli system or collected from plasma from Apolipoprotein Al-Milano carriers. Atherosclerosis and cardiovascular diseases can be treated with the dimer. Medicaments containing the dimer can also be used for preventing thrombosis in different clinical circumstances, both at the arterial and at the venous level. The dimer can also act as a prodrug for the monomer.

Abstract: The invention relates to an expression system giving high extracellular production of apolipoprotein AI-M (Milano) using E. coli and comprises a plasmid carrying an origin of replication, an inducible promoter sequence, a DNA sequence coding for a signal peptide, a DNA sequence coding for apolipoprotein AI-M, and a transcription terminator. The invention also relates to a method of producing apolipoprotein AI-M using the expression system.

Abstract: A process for preparing antibodies specific for an amino acid sequence which comprises immunizing a mammal with a fused protein comprising said amino acid sequence fused to an immunogenic IgG binding protein is disclosed.