Patents by Inventor Erik Holtzapple

Erik Holtzapple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220333123
    Abstract: The invention is directed to methods involved in the production of flavonoids, anthocyanins and other organic compounds. The invention provides cells engineered for the production of flavonoids, anthocyanins and other organic compounds, where the engineered cells include one or more genetic modifications that increase flavonoid production by increasing metabolic flux to flavonoid precursors and/or reducing carbon losses resulting from the production of byproducts.
    Type: Application
    Filed: April 13, 2022
    Publication date: October 20, 2022
    Inventors: Jingyi Li, Nicholas Brideau, Joshua Britton, Erik Holtzapple
  • Publication number: 20220333087
    Abstract: The invention is directed to methods involved in the production of flavonoids, anthocyanins and other organic compounds. The invention provides cells engineered for the production of flavonoids, anthocyanins and other organic compounds, where the engineered cells include one or more genetic modifications that increase flavonoid production by increasing metabolic flux to flavonoid precursors and/or reducing carbon losses resulting from the production of byproducts.
    Type: Application
    Filed: April 13, 2022
    Publication date: October 20, 2022
    Inventors: Jingyi Li, Nicholas Brideau, Joshua Britton, Erik Holtzapple
  • Publication number: 20220333117
    Abstract: The invention is directed to methods involved in the production of flavonoids, anthocyanins and other organic compounds. The invention provides cells engineered for the production of flavonoids, anthocyanins and other organic compounds, where the engineered cells include one or more genetic modifications that increase flavonoid production by increasing metabolic flux to flavonoid precursors and/or reducing carbon losses resulting from the production of byproducts.
    Type: Application
    Filed: April 13, 2022
    Publication date: October 20, 2022
    Inventors: Jingyi Li, Nicholas Brideau, Joshua Britton, Erik Holtzapple
  • Publication number: 20220333118
    Abstract: The invention is directed to methods involved in the production of flavonoids, anthocyanins and other organic compounds. The invention provides cells engineered for the production of flavonoids, anthocyanins and other organic compounds, where the engineered cells include one or more genetic modifications that increase flavonoid production by increasing metabolic flux to flavonoid precursors and/or reducing carbon losses resulting from the production of byproducts.
    Type: Application
    Filed: April 13, 2022
    Publication date: October 20, 2022
    Inventors: Jingyi Li, Nicholas Brideau, Joshua Britton, Erik Holtzapple
  • Publication number: 20220333122
    Abstract: The invention is directed to methods involved in the production of flavonoids, anthocyanins and other organic compounds. The invention provides cells engineered for the production of flavonoids, anthocyanins and other organic compounds, where the engineered cells include one or more genetic modifications that increase flavonoid production by increasing metabolic flux to flavonoid precursors and/or reducing carbon losses resulting from the production of byproducts.
    Type: Application
    Filed: April 13, 2022
    Publication date: October 20, 2022
    Inventors: Jingyi Li, Nicholas Brideau, Joshua Britton, Erik Holtzapple
  • Patent number: 9328336
    Abstract: The present invention provides diacylglycerol acyltransferase (DGAT) genes, including genes encoding localization peptides. The present invention also provides recombinant cells, such as algae, transformed with DGAT genes and methods of using such recombinant cells to produce triglyceride.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: May 3, 2016
    Assignee: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Jane C Schneider, Eric Moellering, Erik Holtzapple, Soyan Lieberman, Gena Roy
  • Patent number: 9017975
    Abstract: The invention relates to acyl-CoA-independent methods of producing fatty alcohols in recombinant host cells engineered to express an alcohol-forming acyl-ACP reductase. The recombinant host cells may be photosynthetic microorganisms, such as cyanobacteria. Isolated nucleic acid molecules, vectors, and recombinant host cells expressing an alcohol-forming acyl-ACP reductase, and systems for producing fatty alcohols via an acyl-CoA-independent pathway, are also provided. Also provided are microorganisms engineered for the secretion of fatty acids and fatty acid derivatives, including fatty alcohols, and methods of producing fatty acid derivatives using such engineering microorganisms.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: April 28, 2015
    Assignee: Synthetic Genomics, Inc.
    Inventors: Erik Holtzapple, Robert C. Brown, Rekha Seshadri, Jennifer Coppersmith, John Verruto
  • Patent number: 8962299
    Abstract: The invention relates to methods for producing a wax ester in recombinant host cells engineered to express a thioesterase, an acyl-CoA synthetase, an alcohol-forming fatty acyl reductase, and a wax ester synthase. The methods of the invention may take place in photosynthetic microorganisms, and particularly in cyanobacteria. Isolated nucleotide molecules and vectors expressing the thioesterase, acyl-CoA synthetase, alcohol-forming fatty acyl reductase, and wax ester synthase, recombinant host cells expressing the thioesterase, acyl-CoA synthetase, alcohol-forming fatty acyl reductase, and wax ester synthase, and systems for producing a wax ester via a pathway using these four enzymes, are also provided.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: February 24, 2015
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Erik Holtzapple, John H. Verruto
  • Patent number: 8921090
    Abstract: The invention relates to acyl-CoA-independent methods of producing a wax ester in recombinant host cells engineered to express an acyl-ACP wax ester synthase, and an alcohol-forming acyl-ACP reductase. The methods of the invention may take place in photosynthetic microorganisms, and particularly in cyanobacteria. Isolated nucleotide molecules and vectors expressing an acyl-ACP wax ester synthase and/or an alcohol-forming acyl-ACP reductase, recombinant host cells expressing an acyl-ACP wax ester synthase and optionally an alcohol-forming acyl-ACP reductase, and systems for producing a wax ester via an acyl-CoA-independent pathway, are also provided.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: December 30, 2014
    Assignee: ExxonMobil Research and Engineering Company
    Inventors: Erik Holtzapple, John H. Verruto
  • Publication number: 20140106417
    Abstract: The present invention provides novel diacylglycerol acyltransferase (DGAT) genes, including novel genes encoding localization peptides. The present invention also provides recombinant cells, such as algae, transformed with DGAT genes and methods of using such recombinant cells to produce triglyceride.
    Type: Application
    Filed: October 16, 2012
    Publication date: April 17, 2014
    Inventors: Jane C Schneider, Eric Moellering, Erik Holtzapple, Soyan Lieberman, Gena Roy
  • Publication number: 20130224811
    Abstract: The invention relates to methods for producing a wax ester in recombinant host cells engineered to express a thioesterase, an acyl-CoA synthetase, an alcohol-forming fatty acyl reductase, and a wax ester synthase. The methods of the invention may take place in photosynthetic microorganisms, and particularly in cyanobacteria. Isolated nucleotide molecules and vectors expressing the thioesterase, acyl-CoA synthetase, alcohol-forming fatty acyl reductase, and wax ester synthase, recombinant host cells expressing the thioesterase, acyl-CoA synthetase, alcohol-forming fatty acyl reductase, and wax ester synthase, and systems for producing a wax ester via a pathway using these four enzymes, are also provided.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 29, 2013
    Applicant: ExxonMobil Research and Engineering Company
    Inventors: Erik Holtzapple, John H. Verruto
  • Publication number: 20130078684
    Abstract: The invention relates to acyl-CoA-independent methods of producing a wax ester in recombinant host cells engineered to express an acyl-ACP wax ester synthase, and an alcohol-forming acyl-ACP reductase. The methods of the invention may take place in photosynthetic microorganisms, and particularly in cyanobacteria. Isolated nucleotide molecules and vectors expressing an acyl-ACP wax ester synthase and/or an alcohol-forming acyl-ACP reductase, recombinant host cells expressing an acyl-ACP wax ester synthase and optionally an alcohol-forming acyl-ACP reductase, and systems for producing a wax ester via an acyl-CoA-independent pathway, are also provided.
    Type: Application
    Filed: March 6, 2012
    Publication date: March 28, 2013
    Applicant: ExxonMobil Research and Engineering Company
    Inventors: Erik Holtzapple, John H. Verruto
  • Publication number: 20110287497
    Abstract: A method for integrating biological conversion of mixed acids to hydrocarbons, hydrocarbon-like molecules, biofuels, and combinations thereof. The method including introducing fermentation products to at least one microorganism chosen from the group consisting of heterotrophic microorganisms, photo-mixotrophic microorganisms, chemo-autotrophic microorganisms, and combinations thereof.
    Type: Application
    Filed: April 26, 2011
    Publication date: November 24, 2011
    Inventors: Mark T. Holtzapple, Cesar B. Granda, Erik Holtzapple