Abstract: The present invention relates to methods of modulating the mannose content of recombinant proteins.

Abstract: A coated cutting tool having a substrate and a coating is provided. The coating includes an inner ?-Al2O3-multilayer and an outer ?-Al2O3-single-layer. The thickness of the inner ?-Al2O3-multilayer is less than or equal to 35% of the sum of the thickness of the inner ?-Al2O3-multilayer and the thickness of the outer ?-Al2O3-single-layer. The sum of the thickness of the inner ?-Al2O3-multilayer and the outer ?-Al2O3-single-layer is 2-15 ?m. The inner ?-Al2O3-multilayer consists of alternating sublayers of ?-Al2O3 and sublayers of TiCO, TiCNO, AlTiCO or AlTiCNO. The inner ?-Al2O3-multilayer can include at least 5 sublayers of ?-Al2O3.

Abstract: A coated cutting tool includes a multilayer of alternating sublayers of ?-Al2O3 and sublayers of TiN, TiC, TiCN, TiCO or TiCNO. The multilayer includes at least 3 sublayers of ?-Al2O3. The multilayer further exhibits an XRD diffraction over a ?-2? scan of 15°-140°, wherein the 0 0 2 diffraction peak (peak area) is the strongest peak originating from the ?-Al2O3 sublayers of the multilayer.

Abstract: A coated cutting tool includes a substrate and a coating. The coating has an ?-Al2O3-multilayer of alternating sublayers of ?-Al2O3 and sublayers of TiCO, TiCNO, AlTiCO or AlTiCNO. The ?-Al2O3-multilayer includes at least 5 sublayers of ?-Al2O3, wherein the total thickness of the ?-Al2O3-multilayer is 1-15 ?m and wherein a period in the ?-Al2O3-multilayer is 50-900 nm. The ?-Al2O3-multilayer exhibits an XRD diffraction over a ?-2? scan of 20°-140°, wherein the relation of the intensity of the 0 0 12 diffraction peak (peak area), I(0 0 12), to the intensities of the 1 1 3 diffraction peak (peak area), I(1 1 3), the 1 1 6 diffraction peak (peak area), I(1 1 6), and the 0 2 4 diffraction peak (peak area), I(0 2 4), is I(0 0 12)/I(1 1 3)>1, I(0 0 12)/I(1 1 6)>1 and I(0 0 12)/I(0 2 4)>1.

Abstract: A coated cutting tool includes a substrate and a coating of one of more layers. The coating includes a layer of ?-Al2O3 of a thickness of 1-20 ?m deposited by chemical vapour deposition (CVD). The ?-Al2O3 layer exhibits an X-ray diffraction pattern and wherein the texture coefficient TC(h k 1) is defined according to the Harris formula, wherein 1<TC(0 2 4)<4 and 3<TC(0 0 12)<6.

Abstract: A coated cutting tool for chip forming machining of metals includes a substrate having a surface coated with a chemical vapour deposition (CVD) coating. The substrate is coated with a coating having a layer of ?-Al2O3, wherein the ?-Al2O3 layer exhibits a texture coefficient TC(0 0 12)?7.2 and wherein the ratio of I(0 0 12)/I(0 1 14)?0.8. The coating further includes a MTCVD TiCN layer located between the substrate and the ?-Al2O3 layer. The MTCVD TiCN layer exhibits a pole figure, as measured by EBSD, in a portion of the MTCVD TiCN layer parallel to the outer surface of the coating and less than 1 ?m from the outer surface of the MTCVD TiCN, wherein a pole plot based on the data of the pole figure, with a bin size of 0.25° over a tilt angle range of 0°???45° from the normal of the outer surface of the coating shows a ratio of intensity within ??15° tilt angle to the intensity within 0°???45° of ?45%.

Abstract: A coated cutting tool having a substrate and a coating is provided. The coating includes an inner ?-Al2O3-multilayer and an outer ?-Al2O3-single-layer. The thickness of the inner ?-Al2O3-multilayer is less than or equal to 35% of the sum of the thickness of the inner ?-Al2O3-multilayer and the thickness of the outer ?-Al2O3-single-layer. The sum of the thickness of the inner ?-Al2O3-multilayer and the outer ?-Al2O3-single-layer is 2-15 ?m. The inner ?-Al2O3-multilayer consists of alternating sublayers of ?-Al2O3 and sublayers of TiCO, TiCNO, AlTiCO or AlTiCNO. The inner ?-Al2O3-multilayer can include at least 5 sublayers of ?-Al2O3.

Abstract: A coated cutting tool for chip forming machining of metals includes a substrate having a surface coated with a chemical vapour deposition (CVD) coating. The substrate is coated with a coating having a layer of ?-Al2O3, wherein the ?-Al2O3 layer exhibits a texture coefficient TC(0 0 12)?7.2 and wherein the ratio of I(0 0 12)/I(0 1 14)?0.8. The coating further includes a MTCVD TiCN layer located between the substrate and the ?-Al2O3 layer. The MTCVD TiCN layer exhibits a pole figure, as measured by EBSD, in a portion of the MTCVD TiCN layer parallel to the outer surface of the coating and less than 1 ?m from the outer surface of the MTCVD TiCN, wherein a pole plot based on the data of the pole figure, with a bin size of 0.25° over a tilt angle range of 0°???45° from the normal of the outer surface of the coating shows a ratio of intensity within ??15° tilt angle to the intensity within 0°???45° of ?45%.

Abstract: A coated cutting tool includes a substrate and a coating of one of more layers. The coating includes a layer of ?-Al2O3 of a thickness of 1-20 ?m deposited by chemical vapour deposition (CVD). The ?-Al2O3 layer exhibits an X-ray diffraction pattern and wherein the texture coefficient TC(h k 1) is defined according to the Harris formula, wherein 1<TC(0 2 4)<4 and 3<TC(0 0 12)<6.

Abstract: The present disclosure relates to a coated cutting tool having a substrate and a coating, wherein the coating includes at least one layer of ?-Al2O3 with a thickness of 1-20 ?m deposited by chemical vapour deposition (CVD). A ?-scan from ?80° to 80° over the (0 0 6) reflection of the ?-Al2O3 layer shows the strongest peak centered around 0° and the full width half maximum (FWHM) of the peak is <25°.

Abstract: A coated cutting tool includes a substrate coated with a multi-layered wear resistant coating having a layer of ?-Al2O3 and a layer of titanium carbonitride TixCyN1-y, with 0.85?x?1.3 and 0.4?y?0.85, deposited on the ?-Al2O3 layer. The TixCyN1-y exhibits a texture coefficient TC(hkl), measured by X-ray diffraction using CuK? radiation and ?-2? scan. The TC(hkl) is defined according to Harris formula: TC ? ( hkl ) = I ? ( hkl ) I 0 ? ( hkl ) ? [ 1 n ? ? n = 1 n ? I ? ( hkl ) I 0 ? ( hkl ) ] - 1 , wherein I(hkl) is the measured intensity (integrated area) of the (hkl) reflection; I0(hkl) is standard intensity of the standard powder diffraction data according to JCPDS card no. 42-1489; n is the number of reflections used in the calculation, and where the (hkl) reflections used are (1 1 1), (2 0 0), (2 2 0), (3 1 1), (3 3 1), (4 2 0) and (4 2 2), and wherein TC(1 1 1)?3.

Abstract: A coated cutting tool includes a multilayer of alternating sublayers of ?-Al2O3 and sublayers of TiN, TiC, TiCN, TiCO or TiCNO. The multilayer includes at least 3 sublayers of ?-Al2O3. The multilayer further exhibits an XRD diffraction over a ?-2?scan of 15°-140°, wherein the 0 0 2 diffraction peak (peak area) is the strongest peak originating from the ?-Al2O3 sublayers of the multilayer.

Abstract: A coated cutting tool includes a substrate and a coating. The coating has an ?-Al2O3-multilayer of alternating sublayers of ?-Al2O3 and sublayers of TiCO, TiCNO, AlTiCO or AlTiCNO. The ?-Al2O3-multilayer includes at least 5 sublayers of ?-Al2O3, wherein the total thickness of the ?-Al2O3-multilayer is 1-15 ?m and wherein a period in the ?-Al2O3-multilayer is 50-900 nm. The ?-Al2O3-multilayer exhibits an XRD diffraction over a ?-2? scan of 20°-140°, wherein the relation of the intensity of the 0 0 12 diffraction peak (peak area), I(0 0 12), to the intensities of the 1 1 3 diffraction peak (peak area), I(1 1 3), the 1 1 6 diffraction peak (peak area), I(1 1 6), and the 0 2 4 diffraction peak (peak area), I(0 2 4), is I(0 0 12)/I(1 1 3)>1, I(0 0 12)/I(1 1 6)>1 and I(0 0 12)/I(0 2 4)>1.

Abstract: A coated cutting tool for chip forming machining of metals includes a substrate having a surface coated with a chemical vapour deposition (CVD) coating. The coated cutting tool has a substrate coated with a coating including a layer of ?-Al2O3, wherein the ?-Al2O3 layer exhibits a dielectric loss of 10?6?tan ??0.0025, as measured with AC at 10 kHz, 100 mV at room temperature of 20° C.

Abstract: A nonlinear control system and a loudspeaker protection system. In particular, a nonlinear control system including a controller, an audio system, and a model is disclosed. The controller is configured to accept one or more input signals, and one or more estimated states produced by the model to produce one or more control signals. The audio system includes one or more transducers configured to accept the control signals to produce a rendered audio stream therefrom. An active loudspeaker with an integrated amplifier is disclosed. A loudspeaker protection system and a quality control system are disclosed. More particularly, a system for clamping the input to a loudspeaker dependent upon a bank of representative models is disclosed.

Abstract: A coated cutting tool insert includes a substrate of cemented carbide, cermet, ceramics, steel or cubic boron nitride having deposited thereon a coating having a total thickness of 60 ?m, including one or more layers having a wear resistant layer of ?-Al2O3 of a thickness of 1 to 45 ?m deposited by chemical vapour deposition (CVD). The ?-Al2O3 layer includes at least two portions, a first thickness portion and a second thickness portion immediately on top of the first thickness portion. The first thickness portion has an essentially columnar ?-Al2O3 grain structure, and at a transition from the first thickness portion to the second thickness portion the grain boundaries of at least 1 out of 25 neighboring grains of the ?-Al2O3 grains undergo a directional change into a direction that is essentially perpendicular, 90±45 degrees, to the grain boundaries in the first thickness portion.

Abstract: A coated cutting tool for chip forming machining of metals includes a substrate having a surface coated with a chemical vapour deposition (CVD) coating. The coating has a layer of ?-Al2O3, wherein the ?-Al2O3 layer exhibits a texture coefficient TC(0 0 12)?7.2 and wherein the ratio of I(0 0 12)/I(0 1 14) is ?1.

Abstract: A nonlinear control system and a loudspeaker protection system. In particular, a nonlinear control system including a controller, an audio system, and a model is disclosed. The controller is configured to accept one or more input signals, and one or more estimated states produced by the model to produce one or more control signals. The audio system includes one or more transducers configured to accept the control signals to produce a rendered audio stream therefrom. An active loudspeaker with an integrated amplifier is disclosed. A loudspeaker protection system and a quality control system are disclosed. More particularly, a system for clamping the input to a loudspeaker dependent upon a bank of representative models is disclosed.

Abstract: The present disclosure relates to a coated cutting tool having a substrate and a coating, wherein the coating includes at least one layer of ?-Al2O3 with a thickness of 1-20 ?m deposited by chemical vapour deposition (CVD). A ?-scan from ?80° to 80° over the (0 0 6) reflection of the ?-Al2O3 layer shows the strongest peak centered around 0° and the full width half maximum (FWHM) of the peak is <25°.