Abstract: The invention relates to a plurality of coated particles containing a solid core containing one of the compounds lenalidomide and pomalidomide, or a pharmaceutically acceptable salt thereof. The core has a mean diameter of the between 0.1 pm and 50 pm. The core is a coated by a coating surrounding, enclosing and/or encapsulating the core. The coating contains a mixed oxide selected from the group consisting of iron oxide, zinc oxide, silicon oxide, titanium oxide, and aluminium oxide.

Abstract: There is provided a pharmaceutical formulation that is useful in delivering a biologic active drug in a high dose, comprising a plurality of particles suspended in an aqueous carrier system, which particles: pharmaceutical formulation, comprising a plurality of particles suspended in a carrier system, which particles: (a) have a weight-, number-, or volume-based mean diameter that is between amount 10 nm and about 700 pm; and (b) comprise solid cores comprising a biologic active drug, coated, at least in part, by a coating of inorganic material, and wherein the formulation comprises a concentration of said biologic active drug of at least 10 mg/ml. Preferred biologic active drug include immunoglobulins, monoclonal antibodies, antibody mimetics, cytokines and cytokine antagonists, and human peptide hormones.

Abstract: There is provided a pharmaceutical formulation that is useful in the treatment of myelodysplastic syndrome, comprising a plurality of particles suspended in an aqueous carrier system, which particles: (a) have a weight-, number-, or volume-based mean diameter that is between amount 10 nm and about 700 ?m; and (b) comprise solid cores comprising azacitidine, or a pharmaceutically-acceptable salt thereof, coated, at least in part, by a coating of inorganic material comprising mixture of: (i) zinc oxide; and (ii) one or more other metal and/or metalloid oxides, wherein the atomic ratio ((i):(ii)) is between at least 1:6 and up to and including about 6:1. Said mixed oxide coated particles are preferably synthesized via a gas phase coating technique, such as atomic layer deposition. The formulation may provide for the delayed or sustained release of azacitidine to treat myelodysplastic syndrome without a burst effect.

Abstract: There is provided a process for the preparation of composition in the form of a plurality of particles having a weight-, number-, and/or volume-based mean diameter that is between amount 10 nm and about 700 ?m, which particles comprise: (a) solid cores, preferably comprising a biologically active agent; and (b) two or more sequentially applied, discrete layers, each of which comprises at least one separately applied coating material, and which two or more layers together surround, enclose and/or encapsulate said cores, which process comprises the sequential steps of: (1) applying an initial layer of at least one coating material to said solid cores by way of a gas phase deposition technique; (2) subjecting the coated particles to agitation to deagglomerate particle aggregates formed during step (1) by way of a sieving step; (3) applying a further layer of at least one coating material to the deagglomerated particles; and (4) optionally repeating steps (2) and (3) one or more times to increase the total thickn

Abstract: A coated cutting tool includes a substrate at least partially coated with a coating. The substrate is made of cemented carbide composed of hard constituents in a metallic. The metallic binder includes more than 60 wt % Ni. The coating has two or more layers, wherein the layer adjacent to the substrate is a W(CxN1-x)y layer, wherein 0.6?x?0.8 and 1.1?y?1.8 with a W(CxN1-x)y layer thickness of 0.4-7 ?m.

Abstract: A coated cutting tool includes a substrate coated with a multi-layered wear resistant coating having a layer of ?-Al2O3 and a layer of titanium carbonitride TixCyN1-y, with 0.85?x?1.3 and 0.4?y?0.85, deposited on the ?-Al2O3 layer. The TixCyN1-y exhibits a texture coefficient TC(hkl), measured by X-ray diffraction using CuK? radiation and ?-2? scan. The TC(hkl) is defined according to Harris formula: TC ? ( hkl ) = I ? ( hkl ) I 0 ? ( hkl ) ? [ 1 n ? ? n = 1 n ? I ? ( hkl ) I 0 ? ( hkl ) ] - 1 , wherein I(hkl) is the measured intensity (integrated area) of the (hkl) reflection; I0(hkl) is standard intensity of the standard powder diffraction data according to JCPDS card no. 42-1489; n is the number of reflections used in the calculation, and where the (hkl) reflections used are (1 1 1), (2 0 0), (2 2 0), (3 1 1), (3 3 1), (4 2 0) and (4 2 2), and wherein TC(1 1 1)?3.

Abstract: A coated cutting tool having a substrate and a coating is provided. The coating includes an inner ?-Al2O3-multilayer and an outer ?-Al2O3-single-layer. The thickness of the inner ?-Al2O3-multilayer is less than or equal to 35% of the sum of the thickness of the inner ?-Al2O3-multilayer and the thickness of the outer ?-Al2O3-single-layer. The sum of the thickness of the inner ?-Al2O3-multilayer and the outer ?-Al2O3-single-layer is 2-15 ?m. The inner ?-Al2O3-multilayer consists of alternating sublayers of ?-Al2O3 and sublayers of TiCO, TiCNO, AlTiCO or AlTiCNO. The inner ?-Al2O3-multilayer can include at least 5 sublayers of ?-Al2O3.

Abstract: A coated cutting tool includes a multilayer of alternating sublayers of ?-Al2O3 and sublayers of TiN, TiC, TiCN, TiCO or TiCNO. The multilayer includes at least 3 sublayers of ?-Al2O3. The multilayer further exhibits an XRD diffraction over a ?-2? scan of 15°-140°, wherein the 0 0 2 diffraction peak (peak area) is the strongest peak originating from the ?-Al2O3 sublayers of the multilayer.

Abstract: A coated cutting tool includes a substrate and a coating. The coating has an ?-Al2O3-multilayer of alternating sublayers of ?-Al2O3 and sublayers of TiCO, TiCNO, AlTiCO or AlTiCNO. The ?-Al2O3-multilayer includes at least 5 sublayers of ?-Al2O3, wherein the total thickness of the ?-Al2O3-multilayer is 1-15 ?m and wherein a period in the ?-Al2O3-multilayer is 50-900 nm. The ?-Al2O3-multilayer exhibits an XRD diffraction over a ?-2? scan of 20°-140°, wherein the relation of the intensity of the 0 0 12 diffraction peak (peak area), I(0 0 12), to the intensities of the 1 1 3 diffraction peak (peak area), I(1 1 3), the 1 1 6 diffraction peak (peak area), I(1 1 6), and the 0 2 4 diffraction peak (peak area), I(0 2 4), is I(0 0 12)/I(1 1 3)>1, I(0 0 12)/I(1 1 6)>1 and I(0 0 12)/I(0 2 4)>1.

Abstract: A coated cutting tool includes a substrate and a coating of one of more layers. The coating includes a layer of ?-Al2O3 of a thickness of 1-20 ?m deposited by chemical vapour deposition (CVD). The ?-Al2O3 layer exhibits an X-ray diffraction pattern and wherein the texture coefficient TC(h k 1) is defined according to the Harris formula, wherein 1<TC(0 2 4)<4 and 3<TC(0 0 12)<6.

Abstract: A coated cutting tool for chip forming machining of metals includes a substrate having a surface coated with a chemical vapour deposition (CVD) coating. The substrate is coated with a coating having a layer of ?-Al2O3, wherein the ?-Al2O3 layer exhibits a texture coefficient TC(0 0 12)?7.2 and wherein the ratio of I(0 0 12)/I(0 1 14)?0.8. The coating further includes a MTCVD TiCN layer located between the substrate and the ?-Al2O3 layer. The MTCVD TiCN layer exhibits a pole figure, as measured by EBSD, in a portion of the MTCVD TiCN layer parallel to the outer surface of the coating and less than 1 ?m from the outer surface of the MTCVD TiCN, wherein a pole plot based on the data of the pole figure, with a bin size of 0.25° over a tilt angle range of 0°???45° from the normal of the outer surface of the coating shows a ratio of intensity within ??15° tilt angle to the intensity within 0°???45° of ?45%.

Abstract: A coated cutting tool having a substrate and a coating is provided. The coating includes an inner ?-Al2O3-multilayer and an outer ?-Al2O3-single-layer. The thickness of the inner ?-Al2O3-multilayer is less than or equal to 35% of the sum of the thickness of the inner ?-Al2O3-multilayer and the thickness of the outer ?-Al2O3-single-layer. The sum of the thickness of the inner ?-Al2O3-multilayer and the outer ?-Al2O3-single-layer is 2-15 ?m. The inner ?-Al2O3-multilayer consists of alternating sublayers of ?-Al2O3 and sublayers of TiCO, TiCNO, AlTiCO or AlTiCNO. The inner ?-Al2O3-multilayer can include at least 5 sublayers of ?-Al2O3.

Abstract: A coated cutting tool includes a substrate and a coating of one of more layers. The coating includes a layer of ?-Al2O3 of a thickness of 1-20 ?m deposited by chemical vapour deposition (CVD). The ?-Al2O3 layer exhibits an X-ray diffraction pattern and wherein the texture coefficient TC(h k 1) is defined according to the Harris formula, wherein 1<TC(0 2 4)<4 and 3<TC(0 0 12)<6.

Abstract: A coated cutting tool for chip forming machining of metals includes a substrate having a surface coated with a chemical vapour deposition (CVD) coating. The substrate is coated with a coating having a layer of ?-Al2O3, wherein the ?-Al2O3 layer exhibits a texture coefficient TC(0 0 12)?7.2 and wherein the ratio of I(0 0 12)/I(0 1 14)?0.8. The coating further includes a MTCVD TiCN layer located between the substrate and the ?-Al2O3 layer. The MTCVD TiCN layer exhibits a pole figure, as measured by EBSD, in a portion of the MTCVD TiCN layer parallel to the outer surface of the coating and less than 1 ?m from the outer surface of the MTCVD TiCN, wherein a pole plot based on the data of the pole figure, with a bin size of 0.25° over a tilt angle range of 0°???45° from the normal of the outer surface of the coating shows a ratio of intensity within ??15° tilt angle to the intensity within 0°???45° of ?45%.

Abstract: The present disclosure relates to a coated cutting tool having a substrate and a coating, wherein the coating includes at least one layer of ?-Al2O3 with a thickness of 1-20 ?m deposited by chemical vapour deposition (CVD). A ?-scan from ?80° to 80° over the (0 0 6) reflection of the ?-Al2O3 layer shows the strongest peak centered around 0° and the full width half maximum (FWHM) of the peak is <25°.

Abstract: A coated cutting tool includes a substrate coated with a multi-layered wear resistant coating having a layer of ?-Al2O3 and a layer of titanium carbonitride TixCyN1-y, with 0.85?x?1.3 and 0.4?y?0.85, deposited on the ?-Al2O3 layer. The TixCyN1-y exhibits a texture coefficient TC(hkl), measured by X-ray diffraction using CuK? radiation and ?-2? scan. The TC(hkl) is defined according to Harris formula: TC ? ( hkl ) = I ? ( hkl ) I 0 ? ( hkl ) ? [ 1 n ? ? n = 1 n ? I ? ( hkl ) I 0 ? ( hkl ) ] - 1 , wherein I(hkl) is the measured intensity (integrated area) of the (hkl) reflection; I0(hkl) is standard intensity of the standard powder diffraction data according to JCPDS card no. 42-1489; n is the number of reflections used in the calculation, and where the (hkl) reflections used are (1 1 1), (2 0 0), (2 2 0), (3 1 1), (3 3 1), (4 2 0) and (4 2 2), and wherein TC(1 1 1)?3.

Abstract: A coated cutting tool includes a multilayer of alternating sublayers of ?-Al2O3 and sublayers of TiN, TiC, TiCN, TiCO or TiCNO. The multilayer includes at least 3 sublayers of ?-Al2O3. The multilayer further exhibits an XRD diffraction over a ?-2?scan of 15°-140°, wherein the 0 0 2 diffraction peak (peak area) is the strongest peak originating from the ?-Al2O3 sublayers of the multilayer.

Abstract: A coated cutting tool includes a substrate and a coating. The coating has an ?-Al2O3-multilayer of alternating sublayers of ?-Al2O3 and sublayers of TiCO, TiCNO, AlTiCO or AlTiCNO. The ?-Al2O3-multilayer includes at least 5 sublayers of ?-Al2O3, wherein the total thickness of the ?-Al2O3-multilayer is 1-15 ?m and wherein a period in the ?-Al2O3-multilayer is 50-900 nm. The ?-Al2O3-multilayer exhibits an XRD diffraction over a ?-2? scan of 20°-140°, wherein the relation of the intensity of the 0 0 12 diffraction peak (peak area), I(0 0 12), to the intensities of the 1 1 3 diffraction peak (peak area), I(1 1 3), the 1 1 6 diffraction peak (peak area), I(1 1 6), and the 0 2 4 diffraction peak (peak area), I(0 2 4), is I(0 0 12)/I(1 1 3)>1, I(0 0 12)/I(1 1 6)>1 and I(0 0 12)/I(0 2 4)>1.

Abstract: A coated cutting tool for chip forming machining of metals includes a substrate having a surface coated with a chemical vapour deposition (CVD) coating. The coated cutting tool has a substrate coated with a coating including a layer of ?-Al2O3, wherein the ?-Al2O3 layer exhibits a dielectric loss of 10?6?tan ??0.0025, as measured with AC at 10 kHz, 100 mV at room temperature of 20° C.