Abstract: The present invention relates to filamentous, i.e. thread-like nanoparticles comprising sterol and a component derived from Quillaja saponaria Molina selected from quillaja acid and quillaja saponin. More particularly, the invention relates to the use of said thread-like nanoparticles in vaccines and drug delivery or adsorption systems systems, methods for their production and uses thereof, such as for use as a vaccine adjuvant and in cancer therapy.

Abstract: The present invention relates to mineral micro-particles comprising phytate (inositol hexaphosphate, IP6). More particularly, the invention provides salts of phytic acid with multivalent metal ions such as Ca2+ and Mg2+ for use in biomolecules delivery or adsorption systems, methods for their production and uses thereof, such as for use as a vaccine adjuvant.

Abstract: The present invention relates to mineral micro-particles comprising phytate (inositol hexaphosphate, IP6). More particularly, the invention provides salts of phytic acid with multivalent metal ions such as Ca2+ and Mg2+ for use in biomolecules delivery or adsorption systems, methods for their production and uses thereof, such as for use as a vaccine adjuvant.

Abstract: The present invention is situated in the field of mineral micro-particles selected from the list consisting of aluminum hydroxide, aluminum phosphate, amorphous aluminium hydroxyphosphate and calcium phosphate micro-particles. More particularly, the invention provides organically-derivatized mineral micro-particles, uses thereof, and methods of preparing the same.

Abstract: An adjuvant combination and a kit useful for immunization is provided. The kit contains an antigenic substance and an adjuvant combination of dimethyl dioctadecyl ammonium bromide (DDA-Br or DDA-Cl) with a monophosphoryl lipid.

Abstract: The present invention relates to a combined DNA/Protein antigen vaccine composition which includes nucleic acid molecules and a mineral-based, negatively charged adjuvant, so as to enhance the immunogenicity of the DNA vaccine efficiently, enhancing not only plasmid DNA vaccines but also providing a novel strategy for immunogenic, multivalent combined protein/DNA vaccine delivery. Preferred adjuvants are aluminum or calcium salts, in particular aluminum phosphate.

Abstract: The invention concerns a radial-piston engine of rotary type of the kind having a valve system comprising apertured disc rings arranged in intersliding relationship, one of said rings being stationary while the other one is arranged to take part in the rotary motion of the rotor. The valve opening relationship is determined by the manual angular positions of the discs. In accordance with the invention, filed injection takes place via an injection nozzle positioned in the stationary disc. The valve ring is formed with a through opening which in response to the position assumed my the rotor at the moment of fuel ignition forms an open communication means between the injection nozzle and the combustion chamber.

Abstract: On the rotary drive shaft (10) of a four-stroke engine is non-rotationally mounted a hub (11) supporting four cylinders (14) wherein pistons (16) are arranged for reciprocal movement radially towards the hub. The hub (11) is provided with a combustion chamber (25) having common inlets and outlets (26, 27) formed in a valve ring (28) rotating together with the hub (11) and sealingly abutting against a stationary port ring (30) having intake and exhaust ports (36, 37) communicating with inlet and outlet channels (34, 35) arranged alternately to assume a position in registry with the inlets and outlets (26, 27) associated with the respective combustion chamber (25). One spark plug (46) for each combustion chamber (25) is arranged to rotate with the hub (11) with the spark plug electrode end projecting into the associated combustion chamber opposite the common valve ring inlets and outlets (26, 27).

Abstract: On the rotary drive shaft of a four stroke engine is non-rotationally mounted a hub supporting four cylinders wherein pistons are arranged for reciprocal movement radially towards the hub. The hub is providing with a combustion chamber having common inlets and outlets formed in a valve ring rotating together with the hub and sealingly abutting against a stationary port ring having intake and exhaust ports communicating with inlet and outlet channels arranged alternatingly to assume a position in registry with the inlets and outlets associated with the respective combustion chamber. One spark plug for each combustion chamber is arranged to rotate with the hub, with the spark plug electrode end projecting into the associated combustion chamber opposite the common valve ring inlets and outlets.

Abstract: A device for determining the depth of anaesthesia of a patient, the device including an optical measuring means (1) for measuring on a part (2) of the patient an optical parameter such as transmission or reflection, which is influenced by the circulation of the blood through this part of the patient's body, and to produce an electric signal which varies in accord with this parameter. This signal is related to the periodic variations in the blood-pressure of the patient and thus has a frequency which coincides with the heart frequency of the patient and a maximum amplitude and a minimum amplitude which are related respectively to the systolic and diastolic blood-pressure of the patient. The signal is applied to signal processing circuits (3) which determine the variation in the period of the signal (.DELTA.(R-R)) and the variation in its maximum amplitude (.DELTA.P.sub.max) or minimum amplitude (.DELTA.P.sub.min) or in the difference between its maximum and minimum amplitudes (.DELTA.(P.sub.max -P.sub.

Abstract: An anti-skid device, which can be detachably mounted on the wheels of a vehicle, is simple to handle, comparatively independent of wheel dimensions, and which poses a minimum of risk of damage to the wheel housing of the vehicle and its brake system, at the same time as the device effectively follows the movements of the tire without risk of losing its hold.An anti-skid device made according to the invention comprises a number of gripping elements (201) interspaced along the periphery of the wheel (6, 7) of the vehicle, and each having the shape of a frame open on one side and with two portions extending over the tread of the tire at a certain distance from each other, the frame having additional frame portions (204, 203), which extend along the plane sides of the wheel of the vehicle.