Patents by Inventor Erik M. Jorgensen
Erik M. Jorgensen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20120208291Abstract: Disclosed herein are methods and compositions relating to the detection and measuring of kinetic binding interactions.Type: ApplicationFiled: April 30, 2010Publication date: August 16, 2012Applicant: Univeristy of Utah Research FoundationInventors: M. Wayne Davis, Erik M. Jorgensen, Joel M. Harris, Christopher E. Hopkins, Joshua R. Wayment, Eric Peterson, Douglas Michael Kriech
-
Patent number: 8232063Abstract: The invention relates to an isolated or recombinant Na+/H+ exchanger comprising an isolated or recombinant Na+/H+ exchanger, particularly to the PBO-4 Na+/H+ exchanger. Also disclosed is an isolated or recombinant protein component of an H+-gated channel which can be affected by extracellular Ca2+ concentration. In particular, the invention relates to PBO-5 and/or PBO-8 and/or a H+-gated channel composed of PBO-5 and PBO-8. The invention relates to compounds isolated from a vertebrate organism, wherein said compounds comprise at least a part of a H+-gated channel or Na+/H+ exchanger. The invention also relates to a method for identifying a component of a H+-gated channel in a vertebrate organism.Type: GrantFiled: August 17, 2011Date of Patent: July 31, 2012Assignee: University of Utah Research FoundationInventors: Erik M. Jorgensen, Asim A. Beg, Paola Nix
-
Publication number: 20120029180Abstract: The invention relates to an isolated or recombinant Na?/H+ exchanger comprising an isolated or recombinant Na+/H+ exchanger, particularly to the PBO-4 Na+/H+ exchanger. Also disclosed is an isolated or recombinant protein component of an H+-grated channel which can be affected by extracellular Ca2+ concentration. In particular, the invention relates to PBO-5 and/or PBO-8 and/or a H+-gated channel composed of PBO-5 and PBO-8. The invention relates to compounds isolated from a vertebrate organism, wherein said compounds comprise at least a part of a H+-gated channel or Na+/H+ exchanger. The invention also relates to a method for identifying a component of a H+-grated channel in a vertebrate organism.Type: ApplicationFiled: August 17, 2011Publication date: February 2, 2012Inventors: Erik M. Jorgensen, Asim A. Beg, Paola Nix
-
Patent number: 8012702Abstract: The invention relates to an isolated or recombinant Na+/H+ exchanger comprising an isolated or recombinant Na+/H+ exchanger, particularly to the PBO-4 Na+/H+ exchanger. Also disclosed is an isolated or recombinant protein component of an H+-gated channel which can be affected by extracellular Ca2+ concentration. In particular, the invention relates to PBO-5 and/or PBO-8 and/or a H+-gated channel composed of PBO-5 and PBO-8. The invention relates to compounds isolated from a vertebrate organism, wherein said compounds comprise at least a part of a H+-gated channel or Na+/H+ exchanger. The invention also relates to a method for identifying a component of a H+-gated channel in a vertebrate organism.Type: GrantFiled: October 15, 2010Date of Patent: September 6, 2011Assignee: University of Utah Research FoundationInventors: Erik M. Jorgensen, Asim A. Beg, Paola Nix
-
Publication number: 20110086775Abstract: The invention relates to an isolated or recombinant Na+/H+ exchanger comprising an isolated or recombinant Na+/H+ exchanger, particularly to the PBO-4 Na+/H+ exchanger. Also disclosed is an isolated or recombinant protein component of an H+-gated channel which can be affected by extracellular Ca2+ concentration. In particular, the invention relates to PBO-5 and/or PBO-8 and/or a H|-gated channel composed of PBO-5 and PBO-8. The invention relates to compounds isolated from a vertebrate organism, wherein said compounds comprise at least a part of a H+-gated channel or Na+/H+ exchanger. The invention also relates to a method for identifying a component of a H+-gated channel in a vertebrate organism.Type: ApplicationFiled: October 15, 2010Publication date: April 14, 2011Inventors: Erik M. Jorgensen, Asim A. Beg, Paola Nix
-
Patent number: 7820791Abstract: The invention relates to an isolated or recombinant Na+/H+ exchanger comprising an isolated or recombinant Na+/H+ exchanger, particularly to the PBO-4 Na+/H+ exchanger. Also disclosed is an isolated or recombinant protein component of an H+-gated channel which can be affected by extracellular Ca2+ concentration. In particular, the invention relates to PBO-5 and/or PBO-8 and/or a H+-gated channel composed of PBO-5 and PBO-8. The invention relates to compounds isolated from a vertebrate organism, wherein said compounds comprise at least a part of a H+-gated channel or Na+/H+ exchanger. The invention also relates to a method for identifying a component of a H+-gated channel in a vertebrate organism.Type: GrantFiled: August 8, 2008Date of Patent: October 26, 2010Assignee: University of Utah Research FoundationInventors: Erik M. Jorgensen, Asim A. Beg, Paola Nix
-
Publication number: 20100160217Abstract: The present invention provides receptor chaperons and means for producing cells having increased and/or decreased expression of nAChR subunit combinations and/or nAChR subtypes, which provide useful models for investigating pharmacological properties of the receptors and regulation of the binding sites of potential nAChR subtypes.Type: ApplicationFiled: May 4, 2006Publication date: June 24, 2010Inventors: Daniel C Williams, Erik M. Jorgensen
-
Publication number: 20090176651Abstract: The invention relates to an isolated or recombinant Na+/H+ exchanger comprising an isolated or recombinant Na+/H+ exchanger, particularly to the PBO-4 Na+/H+ exchanger. Also disclosed is an isolated or recombinant protein component of an H+-gated channel which can be affected by extracellular Ca2+ concentration. In particular, the invention relates to PBO-5 and/or PBO-8 and/or a H+-gated channel composed of PBO-5 and PBO-8. The invention relates to compounds isolated from a vertebrate organism, wherein said compounds comprise at least a part of a H+-gated channel or Na+/H+ exchanger.Type: ApplicationFiled: August 8, 2008Publication date: July 9, 2009Inventors: Erik M. Jorgensen, Asim A. Beg, Paola Nix
-
Patent number: 7368540Abstract: The present invention relates to the field of GABA receptor structure and function. In one aspect, the present invention relates to impairment of the gamma-aminobutyric acid (GABA) receptors in parasitic nematodes, for the purpose of crop protection and/or soil treatment. The invention includes mutated nematode GABA receptor subunits, nematode GABA neuromuscular junction receptor complexes, nucleic acids which encode the mutated and functional receptor complexes, antibodies which selectively bind the GABA receptor complexes and/or subunits, and assays for compounds which adversely affect nematode GABA neuromuscular junction receptor function. The present invention therefore relates broadly to recombinant DNA technology, molecular biology tools, and crop protection and/or soil treatment.Type: GrantFiled: September 30, 2005Date of Patent: May 6, 2008Assignee: University of Utah Research FoundationInventors: Bruce A. Bamber, Erik M. Jorgensen
-
Patent number: 7196244Abstract: The present invention provides methods for generating and identifying mutations in Caenorhabditis elegans. Disclosed herein are methods for introducing DNA into the C. elegans germline, methods for expressing DNA in the C. elegans germline, and methods for generating C. elegans mutants by using controlled mobilization of endogenous and heterologous transposons. Also disclosed are a transgene construct for expression in C. elegans and methods for inserting single copy DNA sequences into the C. elegans germline, and engineering mutations into the C. elegans genome.Type: GrantFiled: June 1, 2000Date of Patent: March 27, 2007Assignee: University of UtahInventors: Jean-Louis Bessereau, Erik M. Jorgensen
-
Patent number: 7038033Abstract: The present invention relates to the field of GABA receptor structure and function. In one aspect, the present invention relates to impairment of the gamma-aminobutyric acid (GABA) receptors in parasitic nematodes, for the purpose of crop protection and/or soil treatment. The invention includes mutated nematode GABA receptor subunits, nematode GABA neuromuscular junction receptor complexes, nucleic acids which encode the mutated and functional receptor complexes, antibodies which selectively bind the GABA receptor complexes and/or subunits, and assays for compounds which adversely affect nematode GABA neuromuscular junction receptor function. The present invention therefore relates broadly to recombinant DNA technology, molecular biology tools, and crop protection and/or soil treatment.Type: GrantFiled: May 24, 2002Date of Patent: May 2, 2006Assignee: University of Utah Research FoundationInventors: Bruce A. Bamber, Erik M. Jorgensen
-
Patent number: 6660846Abstract: Disclosed are invertebrate and vertebrate synaptic vesicle amino acid transporter compositions which define a novel family of transporter proteins, recombinant vectors and cells comprising nucleic acid sequences encoding vertebrate synaptic vesicle amino acid transporter proteins and antibodies directed against such proteins. Also disclosed are methods for utilizing such compositions in screening assays and treatment regimens.Type: GrantFiled: October 23, 1998Date of Patent: December 9, 2003Assignees: The Regents of the University of CA, University of Utah Research FoundationInventors: Robert H. Edwards, Richard J. Reimer, Steven L. McIntire, Erik M. Jorgensen, Kim Schuske
-
Publication number: 20030065144Abstract: The present invention relates to the field of GABA receptor structure and function. In one aspect, the present invention relates to impairment of the gamma-aminobutyric acid (GABA) receptors in parasitic nematodes, for the purpose of crop protection and/or soil treatment. The invention includes mutated nematode GABA receptor subunits, nematode GABA neuromuscular junction receptor complexes, nucleic acids which encode the mutated and functional receptor complexes, antibodies which selectively bind the GABA receptor complexes and/or subunits, and assays for compounds which adversely affect nematode GABA neuromuscular junction receptor function. The present invention therefore relates broadly to recombinant DNA technology, molecular biology tools, and crop protection and/or soil treatment.Type: ApplicationFiled: May 24, 2002Publication date: April 3, 2003Applicant: University of Utah Research FoundationInventors: Bruce A. Bamber, Erik M. Jorgensen
-
Patent number: 6406872Abstract: The present invention relates to the field of GABA receptor structure and function. In one aspect, the present invention relates to impairment of the gamma-aminobutyric acid (GABA) receptors in parasitic nematodes, for the purpose of crop protection and/or soil treatment. The invention includes mutated nematode GABA receptor subunits, nematode GABA neuromuscular junction receptor complexes, nucleic acids which encode the mutated and functional receptor complexes, antibodies which selectively bind the GABA receptor complexes and/or subunits, and assays for compounds which adversely affect nematode GABA neuromuscular junction receptor function. The present invention therefore relates broadly to recombinant DNA technology, molecular biology tools, and crop protection and/or soil treatment.Type: GrantFiled: July 28, 2000Date of Patent: June 18, 2002Assignee: University of Utah Research FoundationInventors: Bruce A. Bamber, Erik M. Jorgensen
-
Patent number: 6407210Abstract: The present invention relates to the field of GABA receptor structure and function. In one aspect, the present invention relates to impairment of the gamma-aminobutyric acid (GABA) receptors in parasitic nematodes, for the purpose of crop protection and/or soil treatment. The invention includes mutated nematode GABA receptor subunits, nematode GABA neuromuscular junction receptor complexes, nucleic acids which encode the mutated and functional receptor complexes, antibodies which selectively bind the GABA receptor complexes and/or subunits, and assays for compounds which adversely affect nematode GABA neuromuscular junction receptor function. The present invention therefore relates broadly to recombinant DNA technology, molecular biology tools, and crop protection and/or soil treatment.Type: GrantFiled: November 8, 1999Date of Patent: June 18, 2002Assignee: University of Utah Research FoundationInventors: Bruce A. Bamber, Erik M. Jorgensen