Patents by Inventor Erik M. Schwiebert

Erik M. Schwiebert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF SUPPRESSING AVERSIVENESS OF PHARMACEUTICALS AND INGESTIBLE MATERIALS
    Publication number: 20220331431
    Abstract: Provided herein are compositions and methods of ameliorating the pharmaceutical aversiveness of active pharmaceutical ingredient (API) by administering the API after or substantially simultaneously with a flavone compound.
    Type: Application
    Filed: September 9, 2020
    Publication date: October 20, 2022
    Inventors: Erik M. Schwiebert, John H. Streiff, Peihua Jiang, Paul A.S. Breslin
  • Treating protein folding disorders with small molecule CFTR correctors
    Patent number: 9221840
    Abstract: Novel CFTR corrector compounds that are effective in rescuing halide efflux in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of screening for CFTR corrector compounds are also described herein. The methods of screening include contacting a cell that endogenously expresses a CFTR mutation with the compound to be screened and detecting a rescue of halide efflux from the cell.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: December 29, 2015
    Assignee: DISCOVERYBIOMED INC.
    Inventor: Erik M. Schwiebert
  • TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS
    Publication number: 20140073632
    Abstract: Novel CFTR corrector compounds that are effective in rescuing halide efflux in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The methods include administering a CFTR corrector compound or pharmaceutically acceptable salt or prodrug thereof. Methods of screening for CFTR corrector compounds are also described herein. The methods of screening include contacting a cell that endogenously expresses a CFTR mutation with the compound to be screened and detecting a rescue of halide efflux from the cell.
    Type: Application
    Filed: May 17, 2012
    Publication date: March 13, 2014
    Applicants: THE UAB RESEARCH FOUNDATION, DISCOVERYBIOMED INC.
    Inventors: Erik M. Schwiebert, James F. Collawn, Zsuzsa Bebok
  • Spiperone derivatives and methods of treating disorders
    Patent number: 8664237
    Abstract: Described herein are spiperone derivative compounds which have been found to be useful in methods of stimulating CaCC and treating disorders (or symptoms thereof) associated with CaCC including cystic fibrosis, wherein a compound of the invention is administered to a subject.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: March 4, 2014
    Assignee: The Johns Hopkins University
    Inventors: William B. Guggino, Erik M. Schwiebert, Lihua Liang
  • SPIPERONE DERIVATIVES AND METHODS OF TREATING DISORDERS
    Publication number: 20120029005
    Abstract: Described herein are spiperone derivative compounds which have been found to be useful in methods of stimulating CaCC and treating disorders (or symptoms thereof) associated with CaCC including cystic fibrosis, wherein a compound of the invention is administered to a subject.
    Type: Application
    Filed: October 1, 2009
    Publication date: February 2, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: William B. Guggino, Erik M. Schwiebert, Lihua Liang