Patents by Inventor Erik M. Stang

Erik M. Stang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses
    Patent number: 9902740
    Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: February 27, 2018
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yong Zhang, Robert M. Borzilleri, Andrew J. Tebben, Erik M. Stang, Andrew F. Donnell, Gretchen M. Schroeder, Heidi L. Perez, Donna D. Wei
  • IAP antagonists
    Patent number: 9783573
    Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: October 10, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Kyoung S. Kim, Heidi L. Perez, Erik M. Stang, David K. Williams, Liping Zhang
  • Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses
    Patent number: 9688694
    Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: June 27, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yong Zhang, Robert M. Borzilleri, Andrew J. Tebben, Erik M. Stang, Andrew F. Donnell, Gretchen M. Schroeder, Heidi L. Perez, Donna D. Wei
  • IAP antagonists
    Patent number: 9637518
    Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: May 2, 2017
    Assignee: Bristol-Myers Squibb Company
    Inventors: Kyoung S. Kim, Liping Zhang, Erik M. Stang
  • MACROCYCLIC BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, PREPARATION AND USES
    Publication number: 20160376288
    Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
    Type: Application
    Filed: June 22, 2016
    Publication date: December 29, 2016
    Inventors: Yong ZHANG, Robert M. BORZILLERI, Andrew J. TEBBEN, Erik M. STANG, Andrew F. DONNELL, Gretchen M. SCHROEDER, Heidi L. PEREZ, Donna D. WEI
  • IAP ANTAGONISTS
    Publication number: 20160376307
    Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Application
    Filed: July 10, 2014
    Publication date: December 29, 2016
    Inventors: Kyoung S. KIM, Liping ZHANG, Erik M. STANG
  • IAP ANTAGONISTS
    Publication number: 20150322111
    Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Application
    Filed: September 17, 2013
    Publication date: November 12, 2015
    Inventors: Robert M. Borzilleri, Kyoung S. Kim, Heidi L. Perez, Erik M. Stang, David K. Williams, Liping Zhang
  • IAP antagonists
    Patent number: 8889712
    Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: November 18, 2014
    Assignee: Bristol-Myers Squibb Company
    Inventors: Robert M. Borzilleri, Heidi L. Perez, Erik M. Stang, Kyoung S. Kim
  • IAP ANTAGONISTS
    Publication number: 20130338081
    Abstract: There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
    Type: Application
    Filed: June 19, 2013
    Publication date: December 19, 2013
    Inventors: Robert M. Borzilleri, Heidi L. Perez, Erik M. Stang, Kyoung S. Kim