Abstract: Disclosed herein are various examples of systems, methods and devices for an oxygen reduction system with a universally compatible, adaptive front end that can be coupled with various different gas sources, wherein the oxygen reduction system determines its operations separate and independent from any signal lines from any upstream components or systems. In one example, the oxygen reduction system determines its functions, operations, and operational states from parameters that it measures from the input gas stream and other internal measurements. In this manner, installation of an oxygen reduction system is simplified, time-efficient and universal, and embodiments of the present disclosure provide for oxygen reduction systems that can be installed in a variety of different environments, applications, and with new or existing natural gas productions sites.