Abstract: A medical device includes a blade support, a blade supported by the blade support, and a pin. The blade support includes a bore with an inner portion oriented toward the blade and an outer portion oriented away from the blade. A discontinuity is located at a boundary between the inner and outer portions of the bore. The pin includes a longitudinal axis and a yaw plane is defined perpendicular to the longitudinal axis. A rotational yaw degree of freedom is defined about the longitudinal axis of the pin. The blade support is operable to rotate about the pin in the yaw degree of freedom, contact the pin at the discontinuity of the bore, and tilts away from the yaw plane at the discontinuity of the bore in response to a force applied in a lateral direction.

Abstract: An articulable mechanism includes a first link, a second link, and a joint structure coupling the first and second links to each other. The joint structure is configured to enable articulation of the first and second link relative to each other. A first pair of guide channels is defined by and extends through the first link. A second pair of guide channels is defined by and extends through the second link. A lining overlays one or more of at least a portion of the joint structure, the first guide channels, or the second guide channels. A pair of actuation elements extends respectively through the first guide channels, past the joint structure, and through the second guide channels. The lining provides an interior guide surface along at least part of a path of the actuation elements extending through the first and second guide channels and past the joint structure.

Abstract: A surgical stapling system can include a reload shaft. The shaft can include an elongate tubular member with have a jaw assembly at the distal end thereof and a coupling collar at the proximal end thereof. The shaft assembly also includes an articulation joint coupling the jaw assembly to the distal end. A drive member and an articulation member extend within the tubular body of the shaft from the proximal end to the distal end. A firing member is connected to the distal end of the drive member such that advancement of the drive beam advances the firing member to close the jaw assemblies and fire staples from a reload positioned in the jaw assembly. The shaft assembly can also include a lockout mechanism to prevent a firing operation on a previously-fired reload or no reload.

Abstract: Hand-held controllers continue to be tracked when illuminators on the controllers are occluded. Image data is captured of a hand holding a physical controller with illuminators, and motion sensor data is received from the controller. A determination is made as to whether illuminator-based pose detection is reliable based on the visibility of the illuminators. When the illuminator-based pose detection is not considered reliable, the controller's pose is determined using hand-tracking data for the hand holding the controller. Tracking information for the controller is determined by considering the spatial relationship between the hand and controller in previous frames and adjusting parameters based on a visibility metric. This facilitates generating virtual content that corresponds with the physical controller's current pose.

Abstract: A medical device includes a wrist link. a tool member, and a tension element. The wrist link includes a discrete first link piece and a discrete second link piece. The first link piece includes a first clevis ear and the second link piece includes a second clevis car. The second link piece is coupled to the first link piece to position the second clevis ear opposite the first clevis car and to define a tension element guide channel between the first link piece and the second link piece. The tool member is coupled to rotate between the first clevis ear and the second clevis car about a tool member rotation axis. The tension element is coupled to the tool member and extends from the tool member through the tension element guide channel. Tension on the tension element urges the tool member to rotate about the tool member rotation axis.

Abstract: A surgical stapling system can include a reload shaft. The shaft can include an elongate tubular member with have a jaw assembly at the distal end thereof and a coupling collar at the proximal end thereof. The shaft assembly also includes an articulation joint coupling the jaw assembly to the distal end. A drive member and an articulation member extend within the tubular body of the shaft from the proximal end to the distal end. A firing member is connected to the distal end of the drive member such that advancement of the drive beam advances the firing member to close the jaw assemblies and fire staples from a reload positioned in the jaw assembly. The shaft assembly can also include a lockout mechanism to prevent a firing operation on a previously-fired reload or no reload.

Abstract: An example brush for cleaning of a substrate with a fluid, the brush comprising a polymeric brush body comprising one or more contact surfaces for cleaning the substrate, a mandrel configured to support the polymeric brush body and comprising a plurality of apertures distributed over a surface of the mandrel, and a bore configured to supply the polymeric brush body with fluid via the plurality of apertures, the bore having a diameter sufficient to supply the plurality of apertures with substantially uniform aperture flow rates.

Abstract: A medical device includes an instrument shaft, a tension element guide, a tension element, and a semisolid sealing substance. The instrument shaft includes a proximal end portion, a distal end portion, and a channel between the proximal end portion and the distal end portion. The tension element guide is at the distal end of the instrument shaft, and includes a proximal seal, a distal seal, and a middle seal between the proximal seal and the distal seal. A sealing substance volume is defined between the proximal seal and the middle seal and holds the sealing substance. The tension element extends from the channel of the instrument shaft, past the proximal seal, through the sealing substance in the sealing substance volume, past the middle seal, past the distal seal, and beyond the tension element guide.

Abstract: The present disclosure provides an electrochemical storage device comprising a plurality of electrochemical cells and a plurality of harnesses which are configured to hold a plurality of wires spaced apart from another wire and/or an electrochemical cell. The present disclosure further provides an electrochemical storage device comprising a plurality of electrochemical cells and a set of at least two metal plates coupled to an enjoining stack of non-planar metal sheets.

Abstract: A battery module comprises at least two energy storage cells arranged in a row to form a block of cells. Each energy storage cell has a pair of electrical terminals. The block of cells is arranged such that the electrical terminals are all on a first side of the block of cells. An intumescent insulating sheet is disposed on the first side of the block of cells, and a high-temperature-resistant sheet is disposed on the first side of the block of cells over the intumescent insulating sheet.

Abstract: Provided herein are compositions including a CaMKK2 inhibitor and an anti-cancer therapeutic agent and methods of treating cancer in a subject by administering a therapeutically effective amount of the composition to a subject. The subject may be selected for treatment based on an immune cell measurement of a sample from the subject. Methods of treating cancer by administering a therapeutically effective amount of a CaMKK2 inhibitor, and administering a therapeutically effective amount of an anti-cancer therapeutic agent to the subject are also provided. Kits including combination of a CaMKK2 inhibitor and another anti-cancer therapeutic agent are also provided.

Abstract: A medical device includes a chassis component having a bottom and an opening defined in the bottom, and a capstan including an upper portion, a lower portion, and a spool between the upper and lower portions. The upper portion of the capstan is supported within the opening of the chassis component. The spool comprises a cable wrap surface and a side wall opposing the bottom of the upper chassis. The side wall of the spool can optionally slope away from the bottom of the chassis component. The medical device can further include a cable guide and a cable. The cable extends from the cable guide to the cable wrap surface of the spool.

Abstract: A medical device includes a blade support, a blade supported by the blade support, and a pin. The blade support includes a bore with an inner portion oriented toward the blade and an outer portion oriented away from the blade. A discontinuity is located at a boundary between the inner and outer portions of the bore. The pin includes a longitudinal axis and a yaw plane is defined perpendicular to the longitudinal axis. A rotational yaw degree of freedom is defined about the longitudinal axis of the pin. The blade support is operable to rotate about the pin in the yaw degree of freedom, contact the pin at the discontinuity of the bore, and tilts away from the yaw plane at the discontinuity of the bore in response to a force applied in a lateral direction.

Abstract: A system architecture for grid electrical energy storage comprising substantial numbers of cells connected in parallel. The lowest level of modularity comprising about eighteen or more individual cells connected in parallel. The disclosed architecture reduces the number of parts, complexity, and variability, while increasing one or more of reliability, service life, and energy capacity of a large-scale grid energy storage system, relative to a conventional multi-parallel string architecture.

Abstract: A laminate and a method for preparing a laminate are provided. The method comprises the steps of providing a container or sheet which comprises a fibrous material, disposing a primer composition onto at least one surface of the container or sheet to form a primer layer on the container or sheet, and also disposing a polymeric liner film onto a surface of the primer layer to form a lined container or sheet. The primer composition comprises at least one sulfopolyester.

Abstract: A portable data-management system based on an analyte testing device which communicates wirelessly with a mobile device. The mobile device runs an application to manage and analyze data obtained by the analyte testing device. The mobile device may assist the user in displaying testing data, identifying patterns to assist healthy behavior or issue warnings based on the collected data. The mobile device may be connected to a network to store user health data for use by other parties.

Abstract: A surgical stapling system can include a reload shaft. The shaft can include an elongate tubular member with have a jaw assembly at the distal end thereof and a coupling collar at the proximal end thereof. The shaft assembly also includes an articulation joint coupling the jaw assembly to the distal end. A drive member and an articulation member extend within the tubular body of the shaft from the proximal end to the distal end. A firing member is connected to the distal end of the drive member such that advancement of the drive beam advances the firing member to close the jaw assemblies and fire staples from a reload positioned in the jaw assembly. The shaft assembly can also include a lockout mechanism to prevent a firing operation on a previously-fired reload or no reload.

Abstract: A surgical stapling system can include a reload shaft. The shaft can include an elongate tubular member with have a jaw assembly at the distal end thereof and a coupling collar at the proximal end thereof. The shaft assembly also includes an articulation joint coupling the jaw assembly to the distal end. A drive member and an articulation member extend within the tubular body of the shaft from the proximal end to the distal end. A firing member is connected to the distal end of the drive member such that advancement of the drive beam advances the firing member to close the jaw assemblies and fire staples from a reload positioned in the jaw assembly. The shaft assembly can also include a lockout mechanism to prevent a firing operation on a previously-fired reload or no reload.

Abstract: A heat-sealable composite film comprising an oriented polyester substrate layer having a first and second surface is provided. Disposed on the first surface of the substrate layer is a heat- sealable polymeric coating layer comprising a styrenic linear block copolymer thermoplastic elastomer, an ethylene vinyl acetate (EVA) copolymer and a tackifying resin. Also described is a sealed container comprising a receptacle containing a food product, and a lid formed from said heat-sealable composite film.

Abstract: A tool member is rotatably coupled to a distal end portion of a shaft and includes a drive pulley and a coupling spool. A mechanical structure is coupled to a proximal end portion of the shaft and includes first and second capstans. The first and second capstans each include a first portion and a second portion. A distal portion of the cable is wrapped at least one revolution about the coupling spool. A first proximal end of the cable is wrapped about the second portion of the first capstan such that a second portion crosses over a first portion of the first proximal end of the cable. The second proximal end of the cable is wrapped about the second portion of the second capstan such that a second portion of the second proximal end of the cable crosses over a first portion of the second proximal end of the cable.