Abstract: Methods and devices are disclosed for a separation device including a sintered polymeric monolith having polymeric microparticulate solids with a pore size from about 0.5 to about 8 microns, a porosity between about 50 percent to about 80 percent and a chromatographic uniformity characterized by an HETP (height equivalent of a theoretical plate) less than about 100 microns.

Abstract: Methods and devices are disclosed for a separation device. A separation device includes a separation module having a separation membrane separating an interior of the separation module into a retentate compartment and a permeate compartment. The retentate compartment includes at least one retentate channel, a feed port fluidly coupled to the at least one retentate channel and a retentate port. The permeate compartment includes at least one permeate channel disposed within the permeate compartment and a permeate port fluidly coupled to the at least one permeate channel. a retentate collector fluidly connected to the retentate port. The device further includes a feed reservoir, a permeate reservoir, a fluidic gate located between the feed reservoir and the separation module, a vent located between the retentate channel and the permeate channel end adjacent the retentate port and a pressure differential source applied across the separation module.